Chat with Open Targets genetics database leveraging text-to-graphQL capabilities of OpenAI Codex.
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May 16, 2025 - Python
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open-targets
Here are 15 public repositories matching this topic...
MCP server for Open Targets data
bioinformatics genomics mcp drug-discovery opentargets biomedical-data open-targets model-context-protocol mcp-server
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May 15, 2026 - Python
GeneticsGPT is an intuitive application that leverages OpenAI's GPT-3.5-turbo model to provide insights and answers to genetic and disease-related questions. By integrating with the Open Targets genetics database and translating natural language queries into GraphQL, it empowers users to easily explore and extract valuable information.
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Nov 2, 2025 - Python
Analyze human genetic knockouts to predict drug efficacy and side effects
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Apr 8, 2026 - Python
Falsifiable drug-target validation: a content-addressed audit engine for direction of effect (inhibit vs. activate), built on Open Targets colocalization and benchmarked against approved drug–target pairs. SHA-locked rules; allowed to refuse.
python bioinformatics gwas reproducible-research computational-biology open-science drug-discovery human-genetics open-targets target-identification drug-target-validation
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Jun 17, 2026 - Python
Powerful Model Context Protocol (MCP) server for therapeutic discovery and drug repurposing using the Open Targets Platform GraphQL API.
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Apr 13, 2026 - Python
Prescribing genes, not just drugs. ETL + dashboard pipeline that cross-references Open Targets, ChEMBL and UniProt to rank therapeutic targets by disease.
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Mar 25, 2026 - Python
Fixture-backed biomedical evidence atlas for browsing neuroplasticity and receptor pharmacology research, with a FastAPI backend and a React frontend.
react python bioinformatics typescript pharmacology pubmed chembl neuroplasticity fastapi evidence-synthesis clinicaltrials open-targets serotonin htr2a
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Jun 4, 2026 - Python
Disease-target knowledge graph: Open Targets ETL into Neo4j, FastAPI REST, and a React explorer with ranked associations and provenance.
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Aug 13, 2026 - Python
Local research-only AI agent for evidence-grounded therapeutic target discovery with PubTator3, Open Targets, Neo4j, ChEMBL/RDKit, and FastAPI.
bioinformatics neo4j pubmed knowledge-graph drug-discovery rdkit pubtator chembl europe-pmc therapeutic-targets fastapi biomedical-literature ai-agent openalex open-targets
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Jun 6, 2026 - Python
Forensic post-mortems for clinical trials. Give it an NCT ID, drug, or target: it classifies why a trial stopped, links the biology across ClinicalTrials.gov, openFDA, Open Targets, and ChEMBL, and returns an evidence-graded report, or refuses to speculate when the stop was not scientific.
python cli bioinformatics computational-biology open-science drug-discovery clinical-trials chembl openfda pharmacovigilance rag llm open-targets clinicaltrials-gov
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Jun 4, 2026 - Python
Deterministic knowledge graph engine that finds multi-hop drug-to-disease paths across 50 rare diseases. Zero LLM calls. Built on NetworkX, RDKit, DuckDB, and live biological databases (ChEMBL, Open Targets, UniProt, Reactome)
bioinformatics cheminformatics computational-biology networkx knowledge-graph drug-discovery drug-repurposing rdkit uniprot deterministic reactome graph-traversal pyton chembl rare-disease duckdb open-targets
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Aug 10, 2026 - Python
Ranks schizophrenia GWAS genes on genetic association, druggability and brain cell-type specificity at once. A triage tool for shortlisting candidates, not a claim to have found drug targets.
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Aug 22, 2026 - Python
TargetIntel-IO is an explainable, rule-based tool that ranks and classifies candidate targets in anti-PD-1-resistant melanoma by therapeutic intent: antibody/IO-combination, biomarker, or small-molecule strategy, with evidence-based reasoning and benchmark-checked accuracy behind every call.
bioinformatics computational-biology drug-discovery biomarker-discovery melanoma target-discovery immuno-oncology open-targets translational-bioinformatics
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Aug 10, 2026 - Python
AI-powered drug repurposing pipeline that federates live data across 8 biomedical databases in real time, ranks candidates via DeepSeek V4 LLM analysis, and visualizes target–drug–protein networks in an interactive 3D knowledge graph.
python open-source bioinformatics ai pubmed knowledge-graph drug-discovery drug-repurposing clinical-trials uniprot chembl openfda translational-research fastapi biomedical-research streamlit open-targets deepseek string-db neglected-diseases
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Jun 21, 2026 - Python
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