Chat with Open Targets genetics database leveraging text-to-graphQL capabilities of OpenAI Codex.
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May 16, 2025 - Python
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open-targets
Here are 25 public repositories matching this topic...
MCP server for Open Targets data
bioinformatics genomics mcp drug-discovery opentargets biomedical-data open-targets model-context-protocol mcp-server
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May 15, 2026 - Python
GeneticsGPT is an intuitive application that leverages OpenAI's GPT-3.5-turbo model to provide insights and answers to genetic and disease-related questions. By integrating with the Open Targets genetics database and translating natural language queries into GraphQL, it empowers users to easily explore and extract valuable information.
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Nov 2, 2025 - Python
Analyze human genetic knockouts to predict drug efficacy and side effects
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Apr 8, 2026 - Python
AI-powered biomarker discovery and explanation tool for the Open Targets Hackathon 2025
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Mar 5, 2026 - HTML
Why the best genetically validated pain target keeps failing in the clinic: a genetic–pharmacological asymmetry at Nav1.7 (SCN9A), worked through single-cell atlases, a homeostatic-compensation model and human genetics.
bioinformatics pain reproducible-research computational-biology open-science clinvar single-cell-rna-seq human-genetics ion-channels gnomad open-targets scn9a drug-target-validation
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Jul 1, 2026 - Jupyter Notebook
Falsifiable drug-target validation: a content-addressed audit engine for direction of effect (inhibit vs. activate), built on Open Targets colocalization and benchmarked against approved drug–target pairs. SHA-locked rules; allowed to refuse.
python bioinformatics gwas reproducible-research computational-biology open-science drug-discovery human-genetics open-targets target-identification drug-target-validation
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Jun 17, 2026 - Python
Scientific MVP for LUAD target prioritization using knowledge graphs, GraphSAGE, and GraphRAG.
machine-learning bioinformatics ngs computational-biology tcga knowledge-graph drug-discovery lung-cancer graphsage graph-neural-networks precision-oncology target-discovery fastapi llm open-targets graphrag mcp-server string-db
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Aug 24, 2026 - Jupyter Notebook
Powerful Model Context Protocol (MCP) server for therapeutic discovery and drug repurposing using the Open Targets Platform GraphQL API.
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Apr 13, 2026 - Python
Turn a candidate gene list and a disease context into a ranked, evidence supported review. Deterministic keyless core, optional Claude agent layer.
bioinformatics r genomics shiny rstats clinvar gene-prioritization variant-interpretation rare-disease evidence-synthesis llm open-targets agentic-ai ellmer
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Aug 15, 2026 - R
Unsupervised clustering of common human diseases based on GWAS and WGS data, with a focus on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
machine-learning gwas genetics hierarchical-clustering system-biology common-diseases open-targets chronic-fatigue-syndrome myalgic-encephalomyelitis post-gwas-analysis
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Jul 27, 2026 - R
A wrapper template around the existing OpenTargets Genetics API allowing anyone to merge in their own data
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Jan 19, 2023 - TypeScript
Shiny app that builds a ranked, multi-source gene list for a disease, with transparent scoring and optional AI curation.
bioinformatics r genomics shiny rstats clinvar gene-prioritization gene-panel gnomad open-targets dgidb panelapp
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Aug 15, 2026 - R
Prescribing genes, not just drugs. ETL + dashboard pipeline that cross-references Open Targets, ChEMBL and UniProt to rank therapeutic targets by disease.
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Mar 25, 2026 - Python
Fixture-backed biomedical evidence atlas for browsing neuroplasticity and receptor pharmacology research, with a FastAPI backend and a React frontend.
react python bioinformatics typescript pharmacology pubmed chembl neuroplasticity fastapi evidence-synthesis clinicaltrials open-targets serotonin htr2a
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Jun 4, 2026 - Python
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Oct 22, 2025 - Jupyter Notebook
Disease-target knowledge graph: Open Targets ETL into Neo4j, FastAPI REST, and a React explorer with ranked associations and provenance.
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Aug 13, 2026 - Python
Local research-only AI agent for evidence-grounded therapeutic target discovery with PubTator3, Open Targets, Neo4j, ChEMBL/RDKit, and FastAPI.
bioinformatics neo4j pubmed knowledge-graph drug-discovery rdkit pubtator chembl europe-pmc therapeutic-targets fastapi biomedical-literature ai-agent openalex open-targets
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Jun 6, 2026 - Python
Biological discovery-graph lab that ranks missing-but-plausible links as candidate discoveries, over provenance-stamped subgraphs from Open Targets, Reactome, STRING and ChEMBL.
bioinformatics vanilla-js data-visualization knowledge-graph drug-repurposing link-prediction cloudflare-workers hypothesis-generation open-targets
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Aug 15, 2026
Forensic post-mortems for clinical trials. Give it an NCT ID, drug, or target: it classifies why a trial stopped, links the biology across ClinicalTrials.gov, openFDA, Open Targets, and ChEMBL, and returns an evidence-graded report, or refuses to speculate when the stop was not scientific.
python cli bioinformatics computational-biology open-science drug-discovery clinical-trials chembl openfda pharmacovigilance rag llm open-targets clinicaltrials-gov
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Jun 4, 2026 - Python
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