On-Target and Off-Target Scoring Algorithms for CRISPR gRNAs
Variant- and Haplotype-aware CRISPR guide design toolkit
CRISPR Guide RNA Designer
Creates a construct developed by the Niles Lab at MIT, designed to deliver a 3' UTR post-transcriptional regulatory element payload to a specific given gene in Plasmodium falciparum.
Fork of Azimuth (Machine Learning-Based Predictive Modelling of CRISPR/Cas9 guide efficiency), updated to work with Python 3.10+
A Python-based CRISPR guide RNA analyzer that identifies SpCas9 target sites and ranks candidate guides using GC content, self-complementarity, homopolymer detection and restriction site screening.
Programmable genome‑writing knowledge graph and GNN toolkit for DNA‑modifying enzymes, combining CRISPR/CAST/Fanzor annotations with ESM‑2 embeddings, GraphSAGE/GAT link prediction, and an editor‑selection API for gene‑editing use cases.
⛓️ Automating construction of oligo library sequences for oligo array synthesis.
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