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Closes #111
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robomics committed Aug 7, 2024
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# Synopsis

This repository contains the source code and input data used for the data analysis and modeling for: Deterioration of multi-level 3D genome organization during breast cancer progression (preprint available soon).
This repository contains the source code and input data used for the data analysis and modeling for: Loss of multi-level 3D genome organization during breast cancer progression (preprint available soon).

Input data download and subsequent analyses are automated using Nextflow and Singularity/Apptainer.

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The following order assumes you want to re-run the entire analysis. If you only want to re-run some steps, feel free to get in touch with us to know which steps you have to run.

1. `run_nfcore_hic.sh`
2. `run_tad_analysis.sh`
3. `run_compartment_analysis.sh`
4. `run_call_tad_cliques_workflow.sh`
5. `run_chrom3d_workflow.sh`
6. `run_nfcore_rnaseq.sh`
7. `run_diff_expression_analysis.sh`
8. `run_nfcore_chipseq.sh`
9. `run_comparative_analysis_hic.sh`
10. `run_comparative_analysis.sh`

Inside the `config` folder there are the following base configs:
2. `run_compress_nfcore_hic_output.sh`
3. `run_nfcore_rnaseq.sh`
4. `run_nfcore_chipseq.sh`
5. `run_diff_expression_analysis.sh`
6. `run_comparative_analysis_hic.sh`
7. `run_detect_structural_variants.sh`
8. `run_compartment_analysis.sh`
9. `run_tad_analysis.sh`
10. `run_call_tad_cliques_workflow.sh`
11. `run_chrom3d_workflow.sh`
12. `run_comparative_analysis.sh`
13. `run_fish.sh`

Inside the `configs` folder there are the following base configs:
- `base_hovig.config`
- `base_linux.config`
- `base_saga.config`
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