Prerequisites: enable CONFIG_NET_IPV6_FRAGMENT=y
There seems to be an issue with IPv6 fragmentation. For example, testing native posix echo server:
ping6 -I zeth 2001:db8::1 -s 1300 -c 1
To echo request Zephyr sends echo reply with the malformed second fragment. Wireshark marks that packet as malformed and ping6 does not succeed.