Skip to content

Commit

Permalink
Update README.md
Browse files Browse the repository at this point in the history
  • Loading branch information
xihaoli authored Nov 9, 2024
1 parent 234daf4 commit f669bd2
Showing 1 changed file with 1 addition and 1 deletion.
2 changes: 1 addition & 1 deletion README.md
Original file line number Diff line number Diff line change
Expand Up @@ -3,7 +3,7 @@
[![License: GPL v3](https://img.shields.io/badge/License-GPLv3-blue.svg)](https://www.gnu.org/licenses/gpl-3.0)

# MetaSTAAR (Meta-analysis of variant-Set Test for Association using Annotation infoRmation)
This is an R package for performing MetaSTAAR procedure in whole genome sequencing studies. A lightweight package implementing MetaSTAAR with a pipeline for performing functionally-informed meta-analysis of sequencing studies is available in <a href="https://github.com/li-lab-genetics/MetaSTAARlite">MetaSTAARlite</a> [<a href="https://github.com/li-lab-genetics/MetaSTAARlite-tutorial">Tutorial</a>].
This is an R package for performing MetaSTAAR procedure in whole genome sequencing studies. A lightweight package implementing MetaSTAAR with a pipeline for performing functionally-informed meta-analysis of sequencing studies is available in <a href="https://github.com/li-lab-genetics/MetaSTAARlite">**MetaSTAARlite**</a> [<a href="https://github.com/li-lab-genetics/MetaSTAARlite-tutorial">**Tutorial**</a>].
## Description
MetaSTAAR is an R package for performing Meta-analysis of variant-Set Test for Association using Annotation infoRmation (MetaSTAAR) procedure in whole genome sequencing (WGS) studies. MetaSTAAR enables functionally-informed rare variant meta-analysis of large WGS studies using an efficient, sparse matrix approach for storing summary statistic, while protecting data privacy of study participants and avoiding sharing subject-level data. MetaSTAAR accounts for relatedness and population structure of continuous and dichotomous traits, and boosts the power of rare variant meta-analysis by incorporating multiple variant functional annotations.
## Workflow Overview
Expand Down

0 comments on commit f669bd2

Please sign in to comment.