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Update JSON, SVG, PNG, TSV and GPML files
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actions-user committed Sep 27, 2023
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67 changes: 29 additions & 38 deletions pathways/WP4155/WP4155.gpml
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@@ -1,5 +1,5 @@
<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Endometrial cancer" Data-Source="WikiPathways" Version="WP4155_r127316" Author="[Khanspers, AlexanderPico, MaintBot, Fehrhart, Egonw]" Last-Modified="20230912231507" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Endometrial cancer" Data-Source="WikiPathways" Version="WP4155_r127383" Author="[Khanspers, AlexanderPico, MaintBot, Fehrhart, Egonw]" Last-Modified="20230926195032" Organism="Homo sapiens">
<Comment Source="WikiPathways-description">Endometrial cancer (EC) is the most common gynecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Expand Down Expand Up @@ -345,7 +345,7 @@ Proteins on this pathway have targeted assays available via the [https://assays.
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Expand Down Expand Up @@ -845,23 +836,10 @@ Proteins on this pathway have targeted assays available via the [https://assays.
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<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25514926</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nucleic Acids Res</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hornbeck PV</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang B</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murray B</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kornhauser JM</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Latham V</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Skrzypek E</bp:AUTHORS>
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<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">epithelial cell of uterus</bp:TERM>
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<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">endometrial cancer</bp:TERM>
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<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1722028</bp:ID>
Expand All @@ -876,15 +854,33 @@ Proteins on this pathway have targeted assays available via the [https://assays.
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nordheim A</bp:AUTHORS>
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<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cancer pathway</bp:TERM>
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<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">epithelial cell of uterus</bp:TERM>
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Expand All @@ -895,11 +891,6 @@ Proteins on this pathway have targeted assays available via the [https://assays.
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roque DM</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Santin AD</bp:AUTHORS>
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Expand All @@ -910,8 +901,8 @@ Proteins on this pathway have targeted assays available via the [https://assays.
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Konecny GE</bp:AUTHORS>
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</Biopax>
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85 changes: 6 additions & 79 deletions pathways/WP4155/WP4155.json
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Original file line number Diff line number Diff line change
Expand Up @@ -1050,38 +1050,6 @@
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Expand Down Expand Up @@ -2872,41 +2840,6 @@
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Expand Down Expand Up @@ -3245,9 +3178,6 @@
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Expand Down Expand Up @@ -3530,7 +3460,7 @@
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Expand Down Expand Up @@ -5688,9 +5618,6 @@
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Expand Down Expand Up @@ -8436,7 +8363,7 @@
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Expand All @@ -8446,7 +8373,7 @@
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Expand All @@ -8455,12 +8382,12 @@
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