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4 changes: 2 additions & 2 deletions pathways/WP5191/WP5191-bibliography.tsv
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ID Database Citation
17339491 Pubmed "Arita M, Ohira T, Sun Y-P, Elangovan S, Chiang N, Serhan CN. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol. 2007 Mar 15;178(6):3912–7. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
23528855 Pubmed "Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Understanding resolvin signaling pathways to improve oral health. Int J Mol Sci. 2013 Mar 8;14(3):5501–18. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
17339491 Pubmed "Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. J Immunol. 2007 Mar 15;178(6):3912–7. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/17339491"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
23528855 Pubmed "Understanding resolvin signaling pathways to improve oral health. Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Int J Mol Sci. 2013 Mar 8;14(3):5501–18. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/23528855"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
40 changes: 20 additions & 20 deletions pathways/WP5191/WP5191-datanodes.tsv
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@@ -1,21 +1,21 @@
Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI
RvE1 Metabolite chebi:81559 wikidata:Q27088537 chebi:81559;chebi:81559 inchikey:AOPOCGPBAIARAV-OTBJXLELSA-N
LTB4 Metabolite chebi:15647 wikidata:Q2704449 chebi:15647;chebi:15647 inchikey:VNYSSYRCGWBHLG-AMOLWHMGSA-N;inchikey:RRTYEHFGQWNQKK-KIQAWMAPSA-N
ATP Metabolite chebi:30616 wikidata:Q27113900 chebi:30616;chebi:30616 inchikey:ZKHQWZAMYRWXGA-KQYNXXCUSA-J
RvD1 Metabolite chebi:81564 wikidata:Q60998703 chebi:81564;chebi:81564 inchikey:OIWTWACQMDFHJG-CCFUIAGSSA-N
cAMP Metabolite chebi:17489 wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N
LTB4R GeneProduct ensembl:ENSG00000213903 ensembl:ENSG00000213903 ncbigene:1241 hgnc.symbol:LTB4R uniprot:G3V244;uniprot:Q15722;uniprot:G3V4Q5
FPR2 GeneProduct ensembl:ENSG00000171049 ensembl:ENSG00000171049 ncbigene:2358 hgnc.symbol:FPR2 uniprot:M0R222;uniprot:P25090;uniprot:M0QXD3;uniprot:A0A024R4P3;uniprot:M0QZ89
PDK1 GeneProduct ensembl:ENSG00000152256 ensembl:ENSG00000152256 ncbigene:5163 hgnc.symbol:PDK1 uniprot:Q15118;uniprot:C9JKT3;uniprot:F8WC75;uniprot:F8WEJ6;uniprot:C9IYB4
AKT1 GeneProduct ensembl:ENSG00000142208 ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56
AKT1 GeneProduct ensembl:ENSG00000142208 ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56
CMKLR1 GeneProduct ensembl:ENSG00000174600 ensembl:ENSG00000174600 ncbigene:1240 hgnc.symbol:CMKLR1 uniprot:F8VSC8;uniprot:Q99788;uniprot:F8VYN7
ERK GeneProduct ncbigene:2048 ensembl:ENSG00000133216 ncbigene:2048 hgnc.symbol:EPHB2 uniprot:B1AKC9;uniprot:P29323;uniprot:Q6NVW1
ADCY1 Protein uniprot:ENSG00000164742
GRK1 Protein uniprot:Q15835 ensembl:ENSG00000185974 ncbigene:6011 hgnc.symbol:GRK1 uniprot:Q15835
PIK3CG Protein uniprot:P48736 ensembl:ENSG00000105851 ncbigene:5294 hgnc.symbol:PIK3CG uniprot:P48736;uniprot:E9PDN7;uniprot:A0A024R720
PI-3 kinase I Protein eccode:2.7.1.137
PIK3CB Protein uniprot:P42338 ensembl:ENSG00000051382 ncbigene:5291 hgnc.symbol:PIK3CB uniprot:C9JYX0;uniprot:C9J345;uniprot:H7C527;uniprot:P42338;uniprot:H7C5C3;uniprot:H7C565;uniprot:Q68DL0;uniprot:H0Y871;uniprot:F8WDJ8
PIK3CA Protein uniprot:P42336 ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336
PIK3CD Protein uniprot:O00329 ensembl:ENSG00000171608 ncbigene:5293 hgnc.symbol:PIK3CD uniprot:B7ZM44;uniprot:F8W9P4;uniprot:O00329;uniprot:A0A2K8FKV1
mTORC2 Protein uniprot:P42345 ensembl:ENSG00000198793 ncbigene:2475 hgnc.symbol:MTOR uniprot:P42345
RvE1 Metabolite chebi:81559 "" wikidata:Q27088537 chebi:81559;chebi:81559 inchikey:AOPOCGPBAIARAV-OTBJXLELSA-N
LTB4 Metabolite chebi:15647 "" wikidata:Q2704449 chebi:15647;chebi:15647 inchikey:VNYSSYRCGWBHLG-AMOLWHMGSA-N;inchikey:RRTYEHFGQWNQKK-KIQAWMAPSA-N
ATP Metabolite chebi:30616 "" wikidata:Q27113900 chebi:30616;chebi:30616 inchikey:ZKHQWZAMYRWXGA-KQYNXXCUSA-J
RvD1 Metabolite chebi:81564 "" wikidata:Q60998703 chebi:81564;chebi:81564 inchikey:OIWTWACQMDFHJG-CCFUIAGSSA-N
cAMP Metabolite chebi:17489 "" wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N
LTB4R GeneProduct ensembl:ENSG00000213903 "" ensembl:ENSG00000213903 ncbigene:1241 hgnc.symbol:LTB4R uniprot:G3V244;uniprot:Q15722;uniprot:G3V4Q5
FPR2 GeneProduct ensembl:ENSG00000171049 "" ensembl:ENSG00000171049 ncbigene:2358 hgnc.symbol:FPR2 uniprot:M0R222;uniprot:P25090;uniprot:M0QXD3;uniprot:A0A024R4P3;uniprot:M0QZ89
PDK1 GeneProduct ensembl:ENSG00000152256 "" ensembl:ENSG00000152256 ncbigene:5163 hgnc.symbol:PDK1 uniprot:Q15118;uniprot:C9JKT3;uniprot:F8WC75;uniprot:F8WEJ6;uniprot:C9IYB4
AKT1 GeneProduct ensembl:ENSG00000142208 "" ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56
AKT1 GeneProduct ensembl:ENSG00000142208 "" ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56
CMKLR1 GeneProduct ensembl:ENSG00000174600 "" ensembl:ENSG00000174600 ncbigene:1240 hgnc.symbol:CMKLR1 uniprot:F8VSC8;uniprot:Q99788;uniprot:F8VYN7
ERK GeneProduct ncbigene:2048 "" ensembl:ENSG00000133216 ncbigene:2048 hgnc.symbol:EPHB2 uniprot:B1AKC9;uniprot:P29323;uniprot:Q6NVW1
ADCY1 Protein uniprot:ENSG00000164742 ""
GRK1 Protein uniprot:Q15835 "" ensembl:ENSG00000185974 ncbigene:6011 hgnc.symbol:GRK1 uniprot:Q15835
PIK3CG Protein uniprot:P48736 "" ensembl:ENSG00000105851 ncbigene:5294 hgnc.symbol:PIK3CG uniprot:P48736;uniprot:E9PDN7;uniprot:A0A024R720
PI-3 kinase I Protein eccode:2.7.1.137 ""
PIK3CB Protein uniprot:P42338 "" ensembl:ENSG00000051382 ncbigene:5291 hgnc.symbol:PIK3CB uniprot:C9JYX0;uniprot:C9J345;uniprot:H7C527;uniprot:P42338;uniprot:H7C5C3;uniprot:H7C565;uniprot:Q68DL0;uniprot:H0Y871;uniprot:F8WDJ8
PIK3CA Protein uniprot:P42336 "" ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336
PIK3CD Protein uniprot:O00329 "" ensembl:ENSG00000171608 ncbigene:5293 hgnc.symbol:PIK3CD uniprot:B7ZM44;uniprot:F8W9P4;uniprot:O00329;uniprot:A0A2K8FKV1
mTORC2 Protein uniprot:P42345 "" ensembl:ENSG00000198793 ncbigene:2475 hgnc.symbol:MTOR uniprot:P42345
45 changes: 25 additions & 20 deletions pathways/WP5191/WP5191.gpml
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<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution" Data-Source="WikiPathways" Version="WP5191_r125329" Author="[ElisaSantarsiero, DeSl, Egonw, Eweitz, Larsgw]" Last-Modified="20230131222223" Organism="Homo sapiens">
<Comment Source="WikiPathways-description">Signaling pathway of Resolvin for resolution of inflammation in Polymorphonuclear Neutrophils and Acinar Cells.</Comment>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Resolvin E1 and resolvin D1 signaling decrease inflammation" Data-Source="WikiPathways" Version="WP5191_r129550" Author="[ElisaSantarsiero, DeSl, Egonw, Eweitz, Larsgw]" Last-Modified="20240512134000" Organism="Homo sapiens">
<Comment Source="WikiPathways-description">Signaling pathway of resolvin for resolution of inflammation in polymorphonuclear neutrophils and acinar cells</Comment>
<BiopaxRef>b80</BiopaxRef>
<Graphics BoardWidth="1387.6666666666679" BoardHeight="597.847882454624" />
<DataNode TextLabel="RvE1" GraphId="a213d" Type="Metabolite">
Expand Down Expand Up @@ -316,24 +316,6 @@
<Group GroupId="ce033" GraphId="f6665" Style="Group" />
<InfoBox CenterX="0.0" CenterY="0.0" />
<Biopax>
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="da0">
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17339491</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Makoto Arita</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Taisuke Ohira</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yee-Ping Sun</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Siva Elangovan</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nan Chiang</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Charles N Serhan</bp:AUTHORS>
</bp:PublicationXref>
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lipid signaling pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000959</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
</bp:openControlledVocabulary>
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a01">
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<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
Expand All @@ -351,6 +333,29 @@
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000096</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
</bp:openControlledVocabulary>
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lipid signaling pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000959</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
</bp:openControlledVocabulary>
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="da0">
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17339491</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pubmed</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Makoto Arita</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Taisuke Ohira</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yee-Ping Sun</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Siva Elangovan</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nan Chiang</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Charles N Serhan</bp:AUTHORS>
</bp:PublicationXref>
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">acinar cell</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000622</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
</bp:openControlledVocabulary>
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b80">
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23528855</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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28 changes: 19 additions & 9 deletions pathways/WP5191/WP5191.json
Original file line number Diff line number Diff line change
Expand Up @@ -1868,6 +1868,16 @@
],
"xrefIdentifier": "CL:0000096"
},
"http://identifiers.org/cl/CL:0000622": {
"gpmlElementName": "openControlledVocabulary",
"id": "http://identifiers.org/cl/CL:0000622",
"ontology": "Cell Type",
"term": "acinar cell",
"type": [
"openControlledVocabulary"
],
"xrefIdentifier": "CL:0000622"
},
"http://identifiers.org/pw/PW:0000959": {
"gpmlElementName": "openControlledVocabulary",
"id": "http://identifiers.org/pw/PW:0000959",
Expand Down Expand Up @@ -2995,13 +3005,13 @@
"@context": [
"https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld",
{
"@base": "http://identifiers.org/wikipathways/WP5191/"
"@base": "WP5191/"
}
],
"author": "[ElisaSantarsiero, DeSl, Egonw, Eweitz, Larsgw]",
"comments": [
{
"content": "Signaling pathway of Resolvin for resolution of inflammation in Polymorphonuclear Neutrophils and Acinar Cells.",
"content": "Signaling pathway of resolvin for resolution of inflammation in polymorphonuclear neutrophils and acinar cells",
"source": "WikiPathways-description"
}
],
Expand Down Expand Up @@ -3062,26 +3072,26 @@
"ee504",
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],
"dataSourceVersion": "WP5191_r125329",
"displayName": "Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution",
"dataSourceVersion": "WP5191_r129550",
"displayName": "Resolvin E1 and resolvin D1 signaling decrease inflammation",
"drawAs": "rect",
"fill": "white",
"fontSize": 12,
"fontWeight": "bold",
"gpmlElementName": "Pathway",
"height": 597.847882454624,
"id": "http://identifiers.org/wikipathways/WP5191",
"id": "WP5191",
"kaavioType": "Group",
"lastModified": "20230131222223",
"name": "Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution",
"lastModified": "20240512134000",
"name": "Resolvin E1 and resolvin D1 signaling decrease inflammation",
"organism": "Homo sapiens",
"padding": 5,
"pathwayVersion": "WP5191",
"standardName": "Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution",
"standardName": "Resolvin E1 and resolvin D1 signaling decrease inflammation",
"stroke": "black",
"strokeWidth": 0,
"textAlign": "left",
"textContent": "Name: Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution\nLast Modified: 20230131222223\nOrganism: Homo sapiens",
"textContent": "Name: Resolvin E1 and resolvin D1 signaling decrease inflammation\nLast Modified: 20240512134000\nOrganism: Homo sapiens",
"type": [
"Pathway",
"http://identifiers.org/pw/PW:0000959"
Expand Down
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