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Denoising autoencoder with contrastive learning for addressing dropout events in scRNA-seq data

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DropDAE

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Introduction

DropDAE (Dropout Denoising Autoencoder) is a novel deep learning framework that improves imputation for high-dimensional data like single-cell RNA sequencing (scRNA-seq).
It uses:

  • A denoising autoencoder structure to reconstruct corrupted input data.
  • An optional triplet loss based on consensus clustering to improve separation between similar and dissimilar cells.

Installation

You can install the development version of DropDAE from GitHub:

```r # install.packages(“devtools”) devtools::install_github(“wanlinjuan/DropDAE”)

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Denoising autoencoder with contrastive learning for addressing dropout events in scRNA-seq data

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