NETosis (Neutrophil Extracellular Trap formation) can promote metastasis, create pre-metastatic niches, and contribute to therapy resistance. Single-cell RNA sequencing allows unprecedented resolution in understanding neutrophil diversity and functional states within tumors.
Operator-theoretic spatial biology framework for tumor–immune interface analysis using Hodge decomposition, antisymmetric commutator geometry, and graph operator dynamics. Validated across HCC, IMC, CABO/NIVO, and a pan-cancer Visium cohort (26 sections, 118k+ spots, 6 cancer types).
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