A variant-first, multi-modality CRISPR design framework that unifies SpCas9 nuclease, base-editor, and prime-editor chemistries under a single typed interface to deliver ranked candidate edits complete with calibrated uncertainty intervals, predicted outcome distributions, and ancestry-stratified, population-aware off-target safety reporting.
python rust machine-learning bioinformatics deep-learning genomics computational-biology crispr variant-calling clinvar uncertainty-estimation genome-editing benchmark-datasets pyo3 base-editing populationgenetics prime-editing haplotype-mapping off-target-analysis guide-rna-design
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Updated
Aug 12, 2026 - Python