COMETS is a software platform for performing computer simulations of spatially structured microbial communities. It is based on stoichiometric modeling of the genome-scale metabolic network of individual microbial species using dynamic flux balance analysis, and on a discrete approximation of diffusion. COMETS is built and maintained by the Daniel Segre Lab at Boston University.
COMETS is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.
Comets is developed with non-commercial use in mind and is presented as-is. To inquire about collaborations or commercial usage and development, please contact us at comets@bu.edu.
The COMETS website is runcomets.org.
Documentation on how to install and use COMETS is found at https://segrelab.github.io/comets-manual/.
COMETS can be downloaded from https://www.runcomets.org/get-started.
We have developed both a Matlab and a python toolbox to interface the Comets software. How to use these toolboxes are described in the documentation.
- Matlab toolbox: github.com/segrelab/comets-toolbox
- Python toolbox: github.com/segrelab/cometspy
If you use COMETS in you scientific work, please cite:
Harcombe, W. R., Riehl, W. J., Dukovski, I., Granger, B. R., Betts, A., Lang, A. H., Bonilla, G., Kar, A., Mehta, M., Marx, C. J. & Segré, D (2014). Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics. Cell reports, 7(4), 1104-1115.
Contributions are welcome and appreciated. Questions and discussions can be raised on Gitter. Issues should be discussed in this forum before they are raised on GitHub. For other questions contact us on email comets@bu.edu.