Data, plots, timeline and journalling about my health management and battle with UC / PSC since January 2005. This grasping of data about myself, even if it gives just an illusion of control, it "works" nonetheless as coping mechanism because sometimes just the illusion is enough to calm down your monkey brain from taking over and the stress to worsen and even cause further malaise.
This is something I wanted to do for many years but never started. A recent double hospitalization in less than a month, and the advent of powerful LLM coding agents gave me the nudge I needed.
| Priority | Main Mechanisms | Key Compounds Involved |
|---|---|---|
| Liver Support | Bile flow, detoxification, antioxidant protection | Ursacol, Silymarin, NAC, Methionine, Choline, TMG, SAMe, Taurine, Omega-3, MSM, Vitamin K2 |
| Anti-inflammatory Control (Systemic + Colon) | Cytokine modulation, gut barrier repair | Adalimumab, Mesalazine, Omega-3, Curcumin (Golden Milk), Quercetin, Boswellia, Psyllium, Probiotics |
| Sleep Optimization | GABAergic, serotonin, and glycine pathways | Magnesium (bisglycinate/taurinate), Theanine, Melatonin, Glycine, Inositol |
- Mechanism: Hydrophilic bile acid → replaces toxic bile salts → reduces cholestasis & inflammation in PSC.
- Dose: Currently 2 × 300 mg (AM) + 3 × 300 mg (bedtime) = 1.5 g/day (align with weight‑based guidance with your hepatologist).
- Optimization: Maintain split dosing (AM + bedtime).
- 2 × 200 mg at lunch + 2 × 200 mg at bedtime (= 800 mg/day). Hepatoprotection via glutathione up‑regulation and NF‑κB modulation.
- 1.5 g lunch + 1.5 g bedtime → hepatic GSH support and mucosal protection.
- 2 g lunch + 2 g bedtime → thiol replenishment & connective‑tissue support.
- Supports BHMT remethylation and may aid bile flow; complements methionine/choline.
- Evidence for cholestasis symptom and enzyme support; avoid late‑evening dosing if stimulating.
- Substrate for bile‑acid conjugation; supportive for bile flow.
- Fat‑soluble vitamin support in cholestasis (bone/INR considerations). Water‑miscible forms if advised.
- Baseline for mucosal control — continue as prescribed.
- Lipid vehicle (milk) + piperine improves absorption.
- At lunch per schedule; maintain split EPA+DHA to ~3 g/day total.
- Remission maintenance and butyrate support. Separate from meds/supps by ~2 h (iron, calcium, NAC, quercetin, mesalazine).
- L. rhamnosus + NutrioneLife at dinner.
- Step‑up options: De Simone formulation (VSL#3) or E. coli Nissle 1917 (Mutaflor) — in afternoon, ≥3–4 h after Bactrim.
- Anti‑inflammatory/anti‑fibrotic; keep ≥3 h away from iron (Noripurum).
- Botanical adjunct for UC inflammation/fibrosis; use standardized extract.
- Sleep onset/maintenance; titrate by 0.5–1 mg steps.
- Improves slow‑wave sleep and thermoregulation.
- Serotonergic/cholinergic modulation for calmer sleep.
- Keep 100–150 mg mid‑afternoon + remainder at bedtime if helpful for wind‑down.
- Keep morning + pre‑bed; avoid high citrate late day if it loosens stools.
Dosing in schedule: 500 mg lunch + 500 mg bedtime.
- Roles: anti‑inflammatory, mast‑cell stabilizer, antifibrotic.
- Spacing: keep ≥3 h away from iron; avoid taking with large calcium/fiber boluses that impair absorption.
- ⚡ Magnesium complex — 2 x 117 mg
- 🌾 Psyllium husk — 10 g (≥250–300 mL water)
- 🍎 Apple Cider Vinegar — 1–3 tbsp (diluted)
- 🍵 Theanine — 250 mg
- 🏋️ Creatine — 10 g
- 💉 Adalimumab — 1 x 40 mg (weekly)
- 💊 Bactrim — 1 tab
- 💊 Mesalazine — 1 x 500 mg
- 💊 Ursacol — 2 x 300 mg
- 🧪 SAMe (S-adenosyl-L-methionine) — 400 mg
- 🧪 Taurine — 1 g
- 🧬 TMG (Trimethylglycine) — 500 mg
- 🌞 Vitamin D3 — 2 x 2000 IU
- 🌿 Boswellia (AKBA-std.) — 300–500 mg
- 🐟 Omega-3 + 🧠 Phosphatidylserine — 2 x 0.8 g | 2 x 50 mg
- 🕸️ NAC — 1.5 g
- 🕸️ Racemethionine + Choline — 2 x (100 mg + 20 mg)
- 🕸️ Silymarin — 2 x 200 mg
- 🛡️ Quercetin — 1 x 500 mg
- 🦴 Calcium — 1 x 500 mg
- 🦵 MSM — 2 g
- ✨ Golden Milk — 7 g (with pepper)
- 🍊 Vitamin C — 1 g
- 🔩 Noripurum — 20 drops (20 mg Fe) → avoid 2–3 h around quercetin/NAC/calcium
- 🧪 E. coli Nissle 1917 (OPTION) — per label
- 🧪 SAMe (S-adenosyl-L-methionine) — 400 mg
- 🧪 VSL#3 / De Simone (OPTION) — 450–900B CFU
- L. rhamnosus — 2 sachets (250 mg)
- 🌾 Psyllium husk — 10 g (≥250–300 mL water)
- 🌿 Boswellia (AKBA-std.) — 300–500 mg
- 🦠 NutrioneLife — 1 sachet
- 🦴 Vitamin K2 (MK-7) — 100–200 µg
- 🕸️ Racemethionine + Choline — 2 x (100 mg + 20 mg)
- 🧪 Taurine — 1 g
- 🧬 TMG (Trimethylglycine) — 500 mg
- 🌙 Melatonin — 1–3 mg (start 1 mg)
- 💊 Ursacol — 3 x 300 mg (900 mg)
- 💤 Glycine — 3 g
- 💤 Myo-Inositol — 3 g
- 🕸️ Silymarin — 2 x 200 mg
- 🛡️ NAC — 1.5 g
- 🛡️ Quercetin — 1 x 500 mg
- 🦵 MSM — 2 g
| Focus | Recommendation |
|---|---|
| Iron absorption | Maintain Noripurum away from quercetin, NAC, and calcium. |
| Bowel motility | If stools become too loose, shift part of magnesium dose earlier or reduce citrate fraction. |
| Methylation balance | You are using TMG 500 mg AM + 500 mg dinner for methyl‑cycle support. |
| Inflammatory control | Curcumin + Omega-3 + Adalimumab + Quercetin + Silymarin create an excellent anti-NF-κB network; avoid unnecessary NSAIDs. |
| Sleep | Maintain fixed bedtime, dim light 1 h before, magnesium/glycine/theanine/inositol at least 30 min pre-sleep. |
- ✅ Strong hepatoprotection: Ursacol + Silymarin + NAC + MSM
- ✅ Anti-inflammatory synergy: Adalimumab + Omega-3 + Curcumin + Quercetin
- ✅ Sleep foundation: Magnesium bisglycinate + Theanine + Glycine + Inositol
⚠️ Manage supplement timing to avoid absorption conflicts (iron ↔ quercetin/NAC).- ⚙️ Optionally recheck hepatic enzymes (γ-GT, ALP) after 6–8 weeks on this adjusted plan to quantify benefit.