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Cosmos

Update

v1.0: July 15, 2025

  • Initial Version of Cosmos

Overview

Cosmos is a Python package for multi-phenotype deep mutational scanning analysis. Specifically, it is suitable for two sequential protein functional phenotypes, one upstream and one downstream - for example, abundance and activity.

Installation

pypi

pip install cosmos-dms

From source

Source code can be found on the GitHub repo pimentellab/cosmos

Cosmos uses Poetry for environment and dependency management.

To install Cosmos, follow these steps:

  1. Install Poetry (if not already installed). Please follow the guideline on Poetry's official documentation.
  2. Clone the repository.
git clone https://github.com/pimentellab/cosmos.git
cd cosmos
  1. Install and activate the environment.
poetry lock
poetry install

Getting started

Check out the vignette/ directory in the source code.

About

A Position-Resolution Causal Model for Direct and Indirect Effects in Protein Functions

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