3.8.0 (2021-09-01)

Added Features

AlphaFold Structures

Structures from DeepMind and EMBL-EBI are shown alongside experimentally determined structures;
The Protein Structure Panel has some other improvements, such as the added ability to change the representation, and coloring, of the structures.
The table also shows some relevant details of the experimental structures, like the residues included in the structure, and the fraction of the total protein in the structure.

Expression Panel Improvements

The Expression Panel has been simplified and improved to show a heatmap of tissues and data sources.
GTEx data is now included along with the other data sources.

Tutorials

There are several tutorials to walk people through the new features of Pharos, or some of the lesser known features
Chemical structure search, the UpSet Charts, Uploading Custom Target Lists, etc. See the main menu item "Tutorials" to access them.

Bug Fixes / Miscellaneous updates

Structure Search now parses input from many different formats

Filter visualizations on the list pages show either a Donut Chart, or an UpSet Chart. Previously there were tabs to show both of them.

3.6.0 (2020-05-01)

TIGA Data Visualizations
- Genome-wide association studies (GWAS) find associations between phenotypic traits and genes. Target Illumination GWAS Analytics (TIGA) scores and ranks those traits according to the a subset of the study parameters.
- From target details pages, you'll see plots and tables of associated GWAS phenotypes, ranked according to the number and quality of GWAS studies involved.
- From disease details pages, you'll see plots and tables of associated targets, ranked accordingly as well.
Ligand Details pages for Drugs include UNIIs
Link out to GlyGen from target details pages
Updated Frequently Asked Questions
Updated database to TCRD 6.11.0
- TCRD_v6.10.0.README
- TCRD_v6.11.0.README

Provide feedback