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Nathan J. O'Connor, PhD, MS

I build AI-enabled scientific workflows and analysis tools for microscopy, with a focus on light-sheet microscopy, deconvolution, neuroinformatics, and scientific Python.

Selected Work

MBF Bioscience — Image Analysis Comparison Metrics

Contributed Python utilities for image analysis comparison metrics in the public MBFBioscience/MBFPythonUtilities repository, particularly in Image/Analysis/Comparison.

These metrics supported analysis used in an associated whitepaper.

  • Focus: scientific image analysis, comparison workflows, and quantitative evaluation

Arnas Technologies

I'm the founder of Arnas Technologies, where I build deconvolution microscopy software and imaging workflows:

  • Arnas Scope — GPU-accelerated 3D deconvolution software for fluorescence microscopy (widefield, confocal, spinning disk, lightsheet, TIRF), available as a Windows GUI, CLI, and SDK/DLL. It carries the algorithmic heritage of AutoQuant AutoDeblur, which I helped create.
  • Arnas View — a real-time 2D deconvolution SDK for OEM integration: a lightweight C-ABI DLL that runs inside the camera acquisition loop at <3.5 ms latency.
  • Arnas Verify — an open reference implementation of the offline signed-license verification used in our desktop products.
  • Bead Analyzer — open-source PSF and FWHM characterization from bead images; the measurement companion to PSF-informed deconvolution.

More on the Arnas blog — fluorescence microscopy, lightsheet imaging, and big-data workflows.

Featured Repositories

An open-source Python tool for characterizing PSF and FWHM measurements from light-microscopic 2D and 3D images of microspheres.

A Python analysis project exploring gender patterns in Wheel of Fortune data.

Current Focus

  • AI-enabled scientific workflows
  • Microscopy image analysis
  • Deconvolution methods
  • Neuroinformatics
  • Scientific Python tooling

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About Nathan J. O'Connor, PhD, MS

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