We are after a list of potential projects that could work with Python under WASI. There's essentially 6 layers to this, each one more specific than the previous, but all accurate for what they claim:

1. All projects on PyPI
2. Projects on PyPI that have a pure Python wheel
3. Projects who only have dependencies that are pure Python wheels
4. Importation of the top-level project succeeds
5. Test suite passes
6. Projects declare their support

We can calculate layers 1 and 2 easily thanks to https://github.com/sethmlarson/pypi-data (although with slightly outdated data). We can calculate layer 2 with sqlite3 pypi.db 'SELECT DISTINCT package_name FROM wheels WHERE python = "py3" OR python = "py2.py3" ORDER BY package_ name ASC' > project_with_pure_wheels.txt.

Layer 3 requires writing a resolver which can resolve for a specific environment and only for specific wheel tags (which helps out with lock files, but it's still work). Layer 4 probably can be automated with introspection inside wheel files and importing module(s) based on what's found in them (luckily WASI is sandboxed, so this should actually be a safe operation). Layer 5 will either have to be some crazy set of heuristics or we accept it as being a per-project thing (plus being able to actually run pytest under WASI). And for layer 6, I have opened https://discuss.python.org/t/do-we-want-classifiers-for-webassembly-on-pypi/22712 to discuss it with the community.