[Saffire 6 USB 2.0](https://fael-downloads-prod.focusrite.com/customer/prod/s3fs-public/downloads/saffire-6-usb-user-guide.pdf) works perfectly with the [official driver](https://fael-downloads-prod.focusrite.com/customer/prod/s3fs-public/downloads/Focusrite_Usb_4.65.5.658.exe) on Windows 10 E LTSC Build 17763 using Rocksmith.ini: LatencyBuffer=2; RS_ASIO.ini: CustomBufferSize=48, Driver=Focusrite USB ASIO, Channel=0 (Channel 0 for input 1 channel 1 for input 2)