Tumour-immunology Journal-sweep

Slides and articles from tumour-immunology journal-sweep meetings.

3rd of March, 2017

Slide-deck: Slides.

1. Nature Medicine: Crome et al, A distinct innate lymphoid cell population regulates tumor-associated T cells.

2. Nature: Eyquem et al, Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

3. Journal of Immunology: Rakhmilevich AL et al, Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model.

4. Immunity: Stephen TL et al, SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells

5. PNAS: Wang H et al, cGAS is essential for the antitumor effect of immune checkpoint blockade.

6. Cancer Cell: Katlinski et al, Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

26th of January, 2017

Slide-dec: Slides.

1st of December, 2016

Slide-deck: Slides.

Articles:

1. J Natl Cancer Inst.: Prehn RT et al, Immunity to methylcholanthrene-induced sarcomas.

2. Cancer Research: Gross L, Intradermal Immunization of C3H Mice Against a Sarcoma That Originated in an Animal of the Same Line.

3. Cancer Research: Hart IR, Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

4. Nature: Pearse AM et al, Allograft theory: transmission of devil facial-tumour disease.

27th of October, 2016

Slide-deck: Slides.

Articles:

1. Science: Liepe J et al, A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

2. Immunity: Bhattacharya N et al, Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer..

3. Cancer Cell: Eggert T et al, Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.

4. Cancer Immunology Research: Prickett TD et al, Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens.

28th of September, 2016

Slide-deck: Slides.

Articles:

1. Cell: Singer M et al, A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

2. Cancer Cell: Young A et al, Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses..

3. Cancer Cell: Liu Y et al, Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.

4. Nature Biotech: Bentzen AK et al, Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.

25th of August, 2016

Slide-deck: Slides.

Articles:

1. Immunity: Scharping NE et al, The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

2. Cancer Cell: Roberts EW et al, Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.

3. Cancer Research: Walton J et al, CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma..

4. Cell: Denny SK et al, Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.

23th of June, 2016

Slide-deck: Slides.

Articles:

1. Nature Cell Biology: Baer C et al, Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity.

2. Nature: Kranz LM et al, Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.

3. Science: Strønen E et al, Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

4. Immunity: Ho SS et al, The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.

26th of May, 2016

Slide-deck: Slides

Articles:

1. Cancer cell: Halama N et al, Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.

2. Nature Biotechnology: Liu L et al, Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy.

3. Cell: Wang W et al, Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.

4. PNAS: Demaria O et al, STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.

5. Immunity: Tinoco R et al, PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.