See the description of the fix https://reviews.llvm.org/D139752 . In short, latest musl has made some _LARGEFILE64_SOURCE change that llvm/lib/Support/raw_ostream.cpp's use of lseek64 fails to build.
This is a 16.0.x candidate so that downstream musl users don't have to patch llvm-project by themselves.
edit: this was identified as a Halide issue: halide/Halide#7319
@kraj