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Description
Here is one possible strategy for "thinning" AppImages so that they contain only the subset of Python and other files that is actually needed. Using this, I could reduce the size of TruFont from approximately 120 MB to just one third, under 40 MB.
mkdir squashfs-root
sudo mount -t tmpfs tmpfs squashfs-root/ -o strictatime,nodiratime
./TruFont-*-x86_64.AppImage --appimage-extract
touch test
./squashfs-root/AppRun
# Kill
find squashfs-root/ -mindepth 3 -not -anewer test -not -path '*/share/icons/*' -not -path '*/share/applications/*' -not -path '*/share/metainfo/*' -delete || true
find squashfs-root/ -type d -empty -delete
./squashfs-root/AppRun
appimagetool ./squashfs-root
The downside is that you need to manually "exercise" all parts of the application, so that the mechanism detects all files that are actually needed.