Upgrade `PyO3` 0.21

[jopemachine]

To upgrade to pyo3 version 0.21, we need to use pyo3-async-runtime instead of pyo3-asyncio since pyo3-asyncio is not actively maintained at the moment.

Ref: https://github.com/PyO3/pyo3-async-runtimes

[jopemachine]

Now we need to upgrade to the new version of pyo3 along with pyo-async-runtimes.