23andMe Coffeecup Demo

making sense of the new york times article

by using coffeecup and the 23andMe api

also see ncbi dbSNP

![table][2] [2]: ./table.png "Table"

The most common variation of the COMT gene is the Val158Met polymorphism (rs4680) in which a single G/A base-pair substitution leads to a valine (Val) to methionine (Met) substitution at codon 158. This Met substitution reduces the activity of COMT enzyme to one-quarter of what is originally encoded by the Val allele. Thereby, Met carriers have higher extracellular DA level in the prefrontal cortex, a region that is vital for affective decision making, as suggested by both lesion and fMRI studies.¹

Footnotes

1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447184/ ↩