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jianhuig authored Mar 18, 2021
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# Family-wise error rate

To emperically evaluate FWER of weighted p-value approach and sFDR, we simulate GWAS z-scores from N(0,1) for variants in 1000 Genome Project. For each simulation, we obatin CADD-score and integrate. The FWER is defined as (#simulations that have at least one findings/ #simulations).
To emperically evaluate FWER of weighted p-value approach and sFDR, we simulate GWAS z-scores from N(0,1) for variants in 1000 Genome Project. For each simulation, we obatin CADD-score and integrate. The FWER is defined as (#simulations that have at least one findings/ #simulations). We also compare the FWER with recently purposed [FINDOR](https://github.com/gkichaev/FINDOR) method.

# Data Preparation

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