This repository contains the code for joint mapping of MAP and CI in the WAKE cohort of CABG surgeries and accompanies xx manuscript.

Files are as follows:

code

Analysis pipeline

• 01_process_timeseries.R
  • purpose: concatenate individual files into one and add time stamps
  • input: individual files for each subject w/ time series data from data/raw/individual
  • output: data/processed/hemo_timeseries.rds: one file w/ all time series data for all subjects
• 02_interpolate.R:
  • purpose: filter based on rules and interpolate based on interpolation criteria
  • input: data/processed/hemo_timeseries.rds
  • output: data/processed/hemo_timeseries_interp.rds
• 03_missingness.R
  • purpose: figure out individuals to exclude for covariates or missingness criteria
  • input: data/processed/hemo_timeseries_interp.rds
  • output: data/processed/exclusion_summary.rds, data/processed/hemo_analytic.rds
• 04_create_analysis_data.R
  • purpose: calculate time in zones
  • input: data/processed/hemo_analytic.rds
  • output: files in data/analytic/ folder
• 05_process_covars.R:
  • purpose: process covariates
  • input: data/raw/WAKE.flatfile.IDsfixed.11.27.24.xlsx
  • output: data/processed/covars_proc.rds
• 06_descriptive_tables.R
  • purpose: generate tables for manuscript
• 07_regressions.R
  • purpose: regressions and statistical tests for manuscript
• 08_plots.R
  • purpose: figures for manuscript

Utilities

• utilities.R: helpful functions for calculating time in ranges
• filtering_settings.R: parameters for filtering data
• processing_fns.R: functions for the data processing

Manuscript

• manuscript_analyses_final.Rmd and manuscript_analyses_final.html: all code for generating tables, figures, and results in manuscript