While you can configure the target OS, target CPU, and general target for the ispc compiler in VS Code settings, there is currently no way to pass custom parameters (ex. --enable-llvm-intrinsics). The "compiler path" option also doesn't seem to work if flags are passed in there.
As a workaround, I'm creating a shell script which redirects options and setting the compiler path to that, but a built-in option would be great.
ispc.sh:
#!/bin/bash
# hack for VS code ISPC extension: extension has no way to set custom compiler flags,
# and ispc.compilerPath needs to be an executable, so I reroute it this way.
ispc --enable-llvm-intrinsics "$@"