Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Finding "next most close" MRCAs #111

Open
hyanwong opened this issue Mar 21, 2024 · 0 comments
Open

Finding "next most close" MRCAs #111

hyanwong opened this issue Mar 21, 2024 · 0 comments

Comments

@hyanwong
Copy link
Owner

It could be that the most recent common ancestor between a position at U and a match at V is only one of several possible common ancestral regions in V, the others of which are slightly more distant. For instance, there could have been a duplication just a little older than the coalescence point, forming 2 "similar" regions between U and V.

At the moment, when we use find_mrca_regions to look for similar regions to impose recombination breakpoints, we only find the most recent, but there is an argument that we should also be finding "reasonably recent" ancestors too, and matching against those, albeit with a lower probability.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant