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Description
PKNCA details about calculation methods are not completely obvious by just looking at the results. One potential fix would be to add this PPANMETH column, which is a recognised SDTM column to detail specific analysis methods used in the calculation of a parameter. We could use it so far for:
- For AUC-based parameters, indicate AUC method of calculation (“lin up/log down”, “linear”, “lin-log”)
- For intervals with
imputecolumn actions, the specific imputation performed - If any global imputation for BLQ or NA action was done, indicate it also in this column.
- When implemented, indicate the reference in parameter-ratio operations
- For lambda Z direct parameters, would be good to indicate if there was any manual inclusion/exclusion!
This will make more transparent and differentiate better PKNCA results
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