For Clickonce deployed .NET FX applications, it is possible to activate the application via .appref-ms file and supply additional arguments, like %userprofile%\Desktop\MyApp.appref-ms arg1,arg2,arg3
.NET FX application would obtain those arguments using AppDomain.CurrentDomain.SetupInformation.ActivationArguments.ActivationData[0]
This experience is not possible in ClickOnce deployed .NET (Core) apps. It is likely due to the use of Launcher, which has access to those arguments, but is not passing them to the app.
See #53 (comment) for more info.