tickTack

tickTack is a package to infer kinetic parameters of an evolving population whose size is observed at discrete intervals of time. The tool is able to

• time simple CNAs for each segment affected by them

• time CNAs in a hierarchical fashion, grouping together segments that most likely underwent a CNA concurrently

Citation

If you use tickTack, please cite:

• Timing and clustering co-occurring genome amplifications in cancers Sara Cocomello, Giovanni Santacatterina, Riccardo Bergamin, Alice Antonello, Giulio Caravagna. biorXiv 2025.

Help and support

Installation

You can install the released version of tickTack from GitHub with:

# install.packages("devtools")
devtools::install_github("caravagnalab/tickTack")

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Copyright and contacts

Sara Cocomello, Giovanni Santacatterina, Giulio Caravagna. Cancer Data Science (CDS) Laboratory, University of Trieste, Italy.