Gradient function

[mattfidler]

Hi @andrewhooker

Is there a place to provide a gradient to speed up the calculation?

Thanks in advance,

Matt

[andrewhooker]

Hi Matt,

There are a number of places a gradient can be supplied. Were you thinking for the FIM calculation, for improving gradient based search algorithms or something else?

Andy

[mattfidler]

Thanks Andy,

Possibly for both. rxode2 calculates these for nlmixr2 focei and I thought they would be useful in both FIM calculation. I didn't see a hook so I didn't know if this was possible.

I was thinking of taking a nlmixr-style model and translating it to PopED, and was wondering if this would be useful and speed up the computation or increase the accuracy. This is currently mostly a development idea, but something I think may be useful.

Matt