This repository contains the source code for the RMSTpowerBoost web application, an interactive tool for designing modern clinical trials.
The easiest way to use the calculator is to access the live, deployed version directly in your web browser. No installation is required.
This web application provides a user-friendly, point-and-click interface for performing complex power and sample size calculations for clinical trials that use the Restricted Mean Survival Time (RMST) as a primary endpoint.
It is designed for biostatisticians, clinical trialists, and researchers who need to design studies using advanced statistical methods without writing R code from scratch.
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Interactive Data Upload: Upload your own pilot dataset in
.csvformat. -
Support for Advanced Models: Implements a wide range of modern statistical methods:
- Linear IPCW Models
- Additive & Multiplicative Stratified Models
- Semiparametric GAMs for non-linear effects
- Dependent Censoring (Competing Risks) Models
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Intuitive Controls: Set all analysis parameters, such as the truncation time (
$\tau$ ), target power, and sample sizes, through a graphical interface. -
Rich Outputs: Instantly generate and view results, including:
- Kaplan-Meier survival plots
- Power vs. Sample Size curves
- Summary tables of effect sizes and results
- A downloadable analysis report
This application is powered by the RMSTpowerBoost R package, which contains all the underlying statistical functions. For users who want to integrate these calculations into their own R scripts, see the full documentation, or contribute to the project, please visit the official package repository.
- Package Website & Source Code: Click Here
If you encounter a bug or have a suggestion for improving the application, please open an issue on this repository's "Issues" tab. Click Here
