"Multi-Set Testing Strategies Show Good Behavior When Applied to Very Large Sets of Rare Variants" was published in Frontiers in Genetics in October 2020. This project built on the intuition of testing biologically informed pathways (a common practice in gene expression analysis) and evaluated from a theoretical standpoint whether a similar approach for genetic data could improve the power of a test of association with a binary outcome. The paper provides power graphs of our simulation results as well as the results of a real data analysis.
This research was conducted as part of an undergraduate team under the direction of Dr. Nathan Tintle as part of the Statistical Genetics and Biostatistics summer research program at Dordt University in the 2018.