Currently the generated js code contains lot of duplicate __extends which can be seen here https://npmcdn.com/@reactivex/rxjs@5.0.0-beta.0/dist/global/Rx.umd.js
var __extends = (this && this.__extends) || function (d, b) {
for (var p in b) if (b.hasOwnProperty(p)) d[p] = b[p];
function __() { this.constructor = d; }
d.prototype = b === null ? Object.create(b) : (__.prototype = b.prototype, new __());
};
This should be avoided by using tsc --noEmitHelpers.