Snapshot version 1.2

This release includes the PK-Sim snapshot (*.json) containing DDI simulations between cimetidine and verapamil
(what is a "PK-Sim snapshot").

The reference model repositories can be found here:

Cimetidine OSP PBPK model
Verapamil OSP PBPK model

Downloads

Cimetidine-Verapamil-DDI PK-Sim snapshot file

Fixed issues and Improvements

• CYP3A4 Ki was adjusted in Cimetidine model.
• NOTE: The new PK-Sim snapshot can be used with PK-Sim 10 or later. If you have an older PK-Sim version: please use the previous model version.

Snapshot version 1.1

This release includes the PK-Sim snapshot (*.json) containing DDI simulations between cimetidine and verapamil
(what is a "PK-Sim snapshot").

The reference model repositories can be found here:

• Cimetidine OSP PBPK model
• Verapamil OSP PBPK model

Downloads

Cimetidine-Verapamil-DDI PK-Sim snapshot file

Fixed issues and Improvements

• Model updated to reflect the changes in PK-Sim 10
• NOTE: The new PK-Sim snapshot can be used with PK-Sim 10 or later. If you have an older PK-Sim version: please use the previous model version.

Snapshot version 1.0

This release contains the PK-Sim snapshot (*.json) file containing DDI simulations between cimetidine and verapamil.

The reference model repositories can be found here:

• Cimetidine OSP PBPK model
• Verapamil OSP PBPK model