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Onaho-Pascal/README.md

Bioinformatics | Chemoinformatics | Primer Design
I code in rust and play sudoku when I am not working. My goal is not merely to be good at what I do, but to be GREAT at what I do. I am willing to learn, more and more. journal-cms_subjects_2021-11_elife-sciences-computational-and-systems-biology-illustration

🔭 Featured Projects (Ongoing and Completed)

Mini Projects Bioinformatics, Chemoinformatics, Biotechnology, Cloud engineering, and Blockchain-Bioinformatics integration:

💊 🧬 Chemoinformatics, Bioinformatics, & Machine Learning Portfolio

Here’s a selection of my recent projects spanning transcriptomics, genomics, and computational modeling, all focused on Sickle Cell Disease (SCD) and bioinformatics applications.

Project Description Stack
Non-HbF Genetic Expressions in Sickle Cell RNA-Seq pipeline identifying non-HbF gene signatures modulated by Hydroxyurea in SCD; includes DESeq2 analysis, GO enrichment, and visualization. R · Bioconductor · DESeq2
ML Approach to Detect Severity in Sickle Cell Disease — 2025 Omics Codeathon Deep learning model trained on multi-omics and clinical datasets to classify SCD severity; integrates data preprocessing, feature engineering, and interpretability. Python · PyTorch · Biopython
HackBio Bioinformatics Tasks (R & Machine Learning) Series of curated tasks covering transcriptomics, data wrangling, and supervised learning; demonstrates reproducible analysis and team collaboration. R · DESeq2 · Bioconductor
Protein Sequence Alignment Comparative protein sequence alignment using global/local algorithms; integrated with Galaxy workflows, MEGA phylogeny, and Weka feature extraction. Galaxy · Weka · MEGA
Sickle Cell Mutation Embedding Analysis Vectorized representations of SCD mutations using k-mer embedding and dimensionality reduction; explores genotype-phenotype clustering. Python · Biopython
Computational ADME Profiling for Small Molecules End-to-end cheminformatics pipeline for predicting ADME properties of candidate compounds; includes SMILES parsing, RDKit descriptor generation, ML-based ADMET prediction, and modular result aggregation. Python · RDKit · scikit-learn
The Bio-Book of Jargons Authored a book that contains a glossary of over 200 terms used across bioinformatics, biotechnology, and synthetic biology fields. NCBI, PubMed Databases

Each repository highlights practical applications of computational biology, from RNA-seq pipelines to ML-driven disease modeling, demonstrating a consistent focus on genomics, precision medicine, and reproducible research.

Snake animation

Tech Stack:

azure bash git jenkins kubernetes linux python

AWS Docker HTML5 Kubernetes Python Linux R Conda Galaxy Nextflow Jupyter Rust RDKit Chimera AutoDock ChEMBL


🏆 GitHub Trophies





📫 How to reach me:

My LinkedIn Account

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  1. Hackbio-Internship Hackbio-Internship Public

    This repository houses the tasks assigned to me for the duration of my internship at Hackbio

    R

  2. Sickle-Cell-Research Sickle-Cell-Research Public

    This repository houses my personal projects on Sickle Cell Disease

    R

  3. Drug-Likeness-and-ADME-Screening-Dashboard Drug-Likeness-and-ADME-Screening-Dashboard Public

    These repository houses Computational Chemo-informatics projects on approaches for the Discovery of Novel Anti-Sickling Agents in Sickle Cell Disease

    Python

  4. Pharmacogenomics-Variant-Frequencies-Relevant-to-Nigerian-Populations Pharmacogenomics-Variant-Frequencies-Relevant-to-Nigerian-Populations Public

    This repository houses the bioinformatics project where frequency of Cancer SNPs are determined in the Nigerian population

    R