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Update targets on proteins. #167

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merged 2 commits into from
Oct 20, 2020
Merged

Update targets on proteins. #167

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821b43c
Update targets on proteins.
Lnaden Oct 20, 2020
61c28e6
Make sure to use the actual target ID not the print name.
Lnaden Oct 20, 2020
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2 changes: 2 additions & 0 deletions data/proteins/RdRP.yml
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Expand Up @@ -3,3 +3,5 @@ name: SARS-CoV-2 RNA Polymerase (NSP12)
description: RNA-dependent, RNA polymerase.
organism: SARS-CoV-2
domain: nsp
targets:
- viral replication
2 changes: 2 additions & 0 deletions data/proteins/helicase.yml
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Expand Up @@ -6,3 +6,5 @@ description: >
has gained interested in a potential disrupting target.
organism: SARS-CoV-2
domain: nsp
targets:
- nsp13 helicase activity
2 changes: 2 additions & 0 deletions data/proteins/nsp7.yml
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Expand Up @@ -3,3 +3,5 @@ name: Coronavirus nonstructural protein 7
description: Suppressor of host genome expression
organism: SARS-CoV-2
domain: nsp
targets:
- viral replication
2 changes: 2 additions & 0 deletions data/proteins/nsp8.yml
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Expand Up @@ -3,3 +3,5 @@ name: Coronavirus nonstructural protein 8
description: Suppressor of host genome expression
organism: SARS-CoV-2
domain: nsp
targets:
- viral replication
2 changes: 1 addition & 1 deletion data/targets/inhibition_of_nsp13_helicase_activity.yml
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@@ -1,5 +1,5 @@
target: nsp13 helicase activity
name: inhibition of nsp13 helicase activity
name: Inhibition of nsp13 helicase activity
description: >
Nsp13, nonstructural protein 13 has multiple functions with an N-terminal metal binding domain (MBD) and a helicase domain (Hel). The nsp13 SARS sequence is conserved and helicase activity is necessary for COVID replication. While this is an attractive target for viral inhibition, there are few reports on nsp13 inhibitors. Helicase inhibition has been used for virus (HSV-amenavir) and cancer treatment (eIF41, RocA rocaglamides), but likely due to its inherent flexibility, inhibitor design is challenging and high throughput screen hits are generally DNA binding artifacts.
proteins:
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