CanIsoNet

We have recently analyzed the pathogenic impact of isoform switching events in 31 disease types covering 27 different cancer types from PCAWG project, and four publicly available RNA-Seq datasets on OIH, Alzheimer's Disease, Parkinson's Disease and Behcet's Disease. Expanding on those results, we have built a user-friendly Disease Specific Isoform Interaction Network (CanIsoNet) database to make our results more accessible to the research community. CanIsoNet is the first webserver that merges isoform switching events in different disease types with their functional impact level and showing them on STRING interaction network. It holds annotations for 11,528 isoforms and 14,357 unique isoform switching events across 31 diseases. CanIsoNet provides followings to the users:

1. Browsing various statistics on disease-specific isoform switching events in each diseases.
   
2. Exploring and visualizing network disruptions in the STRING interaction network.
   
3. Exploring the disease-type specific dMDTs.
   
4. Exploring the isoform switching event in each sample with their expression values.
   

Availability

CanIsoNet is freely available at caniso.net

Citation:

If you use CanIsoNet, please cite the following articles:

Karakulak et al., CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Diseases, Bioinformatics Advances, 2023

Kahraman et al., Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network Scientific Reports, 2020.

Contact Us

tuelay.karakulak@usz.ch

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.