Offloading

.gitignore

@@ -166,3 +166,6 @@ cython_debug/
 
 # uv lock file
 uv.lock
+
+# offloaded data files (offload test)
+_seq_models/

pySEQTarget/SEQopts.py

@@ -1,4 +1,5 @@
 import multiprocessing
+import os
 from dataclasses import dataclass, field
 from typing import List, Literal, Optional
 
@@ -18,7 +19,7 @@ class SEQopts:
     :type bootstrap_CI_method: str
     :param cense_colname: Column name for censoring effect (LTFU, etc.)
     :type cense_colname: str
-    :param cense_denominator: Override to specify denominator patsy formula for censoring models
+    :param cense_denominator: Override to specify denominator patsy formula for censoring models; "1" or "" indicate intercept only model
     :type cense_denominator: Optional[str] or None
     :param cense_numerator: Override to specify numerator patsy formula for censoring models
     :type cense_numerator: Optional[str] or None
@@ -54,8 +55,12 @@ class SEQopts:
     :type km_curves: bool
     :param ncores: Number of cores to use if running in parallel
     :type ncores: int
-    :param numerator: Override to specify the outcome patsy formula for numerator models
+    :param numerator: Override to specify the outcome patsy formula for numerator models; "1" or "" indicate intercept only model
     :type numerator: str
+    :param offload: Boolean to offload intermediate model data to disk
+    :type offload: bool
+    :param offload_dir: Directory to offload intermediate model data
+    :type offload_dir: str
     :param parallel: Boolean to run model fitting in parallel
     :type parallel: bool
     :param plot_colors: List of colors for KM plots, if applicable
@@ -80,8 +85,12 @@ class SEQopts:
     :type treatment_level: List[int]
     :param trial_include: Boolean to force trial values into model covariates
     :type trial_include: bool
+    :param visit_colname: Column name specifying visit number
+    :type visit_colname: str
     :param weight_eligible_colnames: List of column names of length treatment_level to identify which rows are eligible for weight fitting
     :type weight_eligible_colnames: List[str]
+    :param weight_fit_method: The fitting method to be used ["newton", "bfgs", "lbfgs", "nm"], default "newton"
+    :type weight_fit_method: str
     :param weight_min: Minimum weight
     :type weight_min: float
     :param weight_max: Maximum weight
@@ -120,6 +129,8 @@ class SEQopts:
     km_curves: bool = False
     ncores: int = multiprocessing.cpu_count()
     numerator: Optional[str] = None
+    offload: bool = False
+    offload_dir: str = "_seq_models"
     parallel: bool = False
     plot_colors: List[str] = field(
         default_factory=lambda: ["#F8766D", "#00BFC4", "#555555"]
@@ -136,6 +147,7 @@ class SEQopts:
     trial_include: bool = True
     visit_colname: str = None
     weight_eligible_colnames: List[str] = field(default_factory=lambda: [])
+    weight_fit_method: Literal["newton", "bfgs", "lbfgs", "nm"] = "newton"
     weight_min: float = 0.0
     weight_max: float = None
     weight_lag_condition: bool = True
@@ -195,3 +207,6 @@ def __post_init__(self):
             attr = getattr(self, i)
             if attr is not None and not isinstance(attr, list):
                 setattr(self, i, "".join(attr.split()))
+
+        if self.offload:
+            os.makedirs(self.offload_dir, exist_ok=True)

pySEQTarget/SEQuential.py

@@ -12,15 +12,15 @@
                        _subgroup_fit)
 from .error import _data_checker, _param_checker
 from .expansion import _binder, _diagnostics, _dynamic, _random_selection
-from .helpers import _col_string, _format_time, bootstrap_loop
+from .helpers import Offloader, _col_string, _format_time, bootstrap_loop
 from .initialization import (_cense_denominator, _cense_numerator,
                              _denominator, _numerator, _outcome)
 from .plot import _survival_plot
 from .SEQopts import SEQopts
 from .SEQoutput import SEQoutput
 from .weighting import (_fit_denominator, _fit_LTFU, _fit_numerator,
-                        _fit_visit, _weight_bind, _weight_predict,
-                        _weight_setup, _weight_stats)
+                        _fit_visit, _offload_weights, _weight_bind,
+                        _weight_predict, _weight_setup, _weight_stats)
 
 
 class SEQuential:
@@ -84,6 +84,8 @@ def __init__(
             np.random.RandomState(self.seed) if self.seed is not None else np.random
         )
 
+        self._offloader = Offloader(enabled=self.offload, dir=self.offload_dir)
+
         if self.covariates is None:
             self.covariates = _outcome(self)
 
@@ -201,6 +203,9 @@ def fit(self) -> None:
             raise ValueError(
                 "Bootstrap sampling not found. Please run the 'bootstrap' method before fitting with bootstrapping."
             )
+        boot_idx = None
+        if hasattr(self, "_current_boot_idx"):
+            boot_idx = self._current_boot_idx
 
         if self.weighted:
             WDT = _weight_setup(self)
@@ -217,6 +222,9 @@ def fit(self) -> None:
             _fit_numerator(self, WDT)
             _fit_denominator(self, WDT)
 
+            if self.offload:
+                _offload_weights(self, boot_idx)
+
             WDT = pl.from_pandas(WDT)
             WDT = _weight_predict(self, WDT)
             _weight_bind(self, WDT)
@@ -244,6 +252,11 @@ def fit(self) -> None:
                 self.weighted,
                 "weight",
             )
+        if self.offload:
+            offloaded_models = {}
+            for key, model in models.items():
+                offloaded_models[key] = self._offloader.save_model(model, key, boot_idx)
+            return offloaded_models
         return models
 
     def survival(self, **kwargs) -> None:

pySEQTarget/analysis/_hazard.py

@@ -4,6 +4,8 @@
 import polars as pl
 from lifelines import CoxPHFitter
 
+from ..helpers._predict_model import _safe_predict
+
 
 def _calculate_hazard(self):
     if self.subgroup_colname is None:
@@ -93,8 +95,10 @@ def _hazard_handler(self, data, idx, boot_idx, rng):
     else:
         model_dict = self.outcome_model[boot_idx]
 
-    outcome_model = model_dict["outcome"]
-    ce_model = model_dict.get("compevent", None) if self.compevent_colname else None
+    outcome_model = self._offloader.load_model(model_dict["outcome"])
+    ce_model = None
+    if self.compevent_colname and "compevent" in model_dict:
+        ce_model = self._offloader.load_model(model_dict["compevent"])
 
     all_treatments = []
     for val in self.treatment_level:
@@ -103,13 +107,14 @@ def _hazard_handler(self, data, idx, boot_idx, rng):
         )
 
         tmp_pd = tmp.to_pandas()
-        outcome_prob = outcome_model.predict(tmp_pd)
+        outcome_prob = _safe_predict(outcome_model, tmp_pd)
         outcome_sim = rng.binomial(1, outcome_prob)
 
         tmp = tmp.with_columns([pl.Series("outcome", outcome_sim)])
 
         if ce_model is not None:
-            ce_prob = ce_model.predict(tmp_pd)
+            ce_tmp_pd = tmp.to_pandas()
+            ce_prob = _safe_predict(ce_model, ce_tmp_pd)
             ce_sim = rng.binomial(1, ce_prob)
             tmp = tmp.with_columns([pl.Series("ce", ce_sim)])
 

pySEQTarget/analysis/_survival_pred.py

@@ -1,5 +1,7 @@
 import polars as pl
 
+from ..helpers._predict_model import _safe_predict
+
 
 def _get_outcome_predictions(self, TxDT, idx=None):
     data = TxDT.to_pandas()
@@ -9,9 +11,12 @@ def _get_outcome_predictions(self, TxDT, idx=None):
 
     for boot_model in self.outcome_model:
         model_dict = boot_model[idx] if idx is not None else boot_model
-        predictions["outcome"].append(model_dict["outcome"].predict(data))
+        outcome_model = self._offloader.load_model(model_dict["outcome"])
+        predictions["outcome"].append(_safe_predict(outcome_model, data.copy()))
+
         if self.compevent_colname is not None:
-            predictions["compevent"].append(model_dict["compevent"].predict(data))
+            compevent_model = self._offloader.load_model(model_dict["compevent"])
+            predictions["compevent"].append(_safe_predict(compevent_model, data.copy()))
 
     return predictions
 

pySEQTarget/helpers/__init__.py

@@ -1,6 +1,7 @@
 from ._bootstrap import bootstrap_loop as bootstrap_loop
 from ._col_string import _col_string as _col_string
 from ._format_time import _format_time as _format_time
+from ._offloader import Offloader as Offloader
 from ._output_files import _build_md as _build_md
 from ._output_files import _build_pdf as _build_pdf
 from ._pad import _pad as _pad

pySEQTarget/helpers/_bootstrap.py

@@ -39,7 +39,10 @@ def _bootstrap_worker(obj, method_name, original_DT, i, seed, args, kwargs):
     obj._rng = (
         np.random.RandomState(seed + i) if seed is not None else np.random.RandomState()
     )
+    original_DT = obj._offloader.load_dataframe(original_DT)
     obj.DT = _prepare_boot_data(obj, original_DT, i)
+    del original_DT
+    obj._current_boot_idx = i + 1
 
     # Disable bootstrapping to prevent recursion
     obj.bootstrap_nboot = 0
@@ -60,6 +63,7 @@ def wrapper(self, *args, **kwargs):
         results = []
         original_DT = self.DT
 
+        self._current_boot_idx = None
         full = method(self, *args, **kwargs)
         results.append(full)
 
@@ -71,17 +75,20 @@ def wrapper(self, *args, **kwargs):
             seed = getattr(self, "seed", None)
             method_name = method.__name__
 
+            original_DT_ref = self._offloader.save_dataframe(original_DT, "_DT")
+
             if getattr(self, "parallel", False):
                 original_rng = getattr(self, "_rng", None)
                 self._rng = None
+                self.DT = None
 
                 with ProcessPoolExecutor(max_workers=ncores) as executor:
                     futures = [
                         executor.submit(
                             _bootstrap_worker,
                             self,
                             method_name,
-                            original_DT,
+                            original_DT_ref,
                             i,
                             seed,
                             args,
@@ -95,13 +102,21 @@ def wrapper(self, *args, **kwargs):
                         results.append(j.result())
 
                 self._rng = original_rng
+                self.DT = self._offloader.load_dataframe(original_DT_ref)
             else:
+                original_DT_ref = self._offloader.save_dataframe(original_DT, "_DT")
+                del original_DT
                 for i in tqdm(range(nboot), desc="Bootstrapping..."):
-                    self.DT = _prepare_boot_data(self, original_DT, i)
+                    self._current_boot_idx = i + 1
+                    tmp = self._offloader.load_dataframe(original_DT_ref)
+                    self.DT = _prepare_boot_data(self, tmp, i)
+                    del tmp
+                    self.bootstrap_nboot = 0
                     boot_fit = method(self, *args, **kwargs)
                     results.append(boot_fit)
 
-            self.DT = original_DT
+                self.bootstrap_nboot = nboot
+                self.DT = self._offloader.load_dataframe(original_DT_ref)
 
             end = time.perf_counter()
             self._model_time = _format_time(start, end)

pySEQTarget/helpers/_fix_categories.py

@@ -0,0 +1,15 @@
+def _fix_categories_for_predict(model, newdata):
+    """
+    Fix categorical column ordering in newdata to match what the model expects.
+    """
+    if hasattr(model, 'model') and hasattr(model.model, 'data') and hasattr(model.model.data, 'design_info'):
+        design_info = model.model.data.design_info
+        for factor, factor_info in design_info.factor_infos.items():
+            if factor_info.type == 'categorical':
+                col_name = factor.name()
+                if col_name in newdata.columns:
+                    expected_categories = list(factor_info.categories)
+                    newdata[col_name] = newdata[col_name].astype(str)
+                    newdata[col_name] = newdata[col_name].astype('category')
+                    newdata[col_name] = newdata[col_name].cat.set_categories(expected_categories)
+    return newdata

pySEQTarget/helpers/_offloader.py

@@ -0,0 +1,53 @@
+from pathlib import Path
+from typing import Any, Optional, Union
+
+import joblib
+import polars as pl
+
+
+class Offloader:
+    """Manages disk-based storage for models and intermediate data"""
+
+    def __init__(self, enabled: bool, dir: str, compression: int = 3):
+        self.enabled = enabled
+        self.dir = Path(dir)
+        self.compression = compression
+
+    def save_model(
+        self, model: Any, name: str, boot_idx: Optional[int] = None
+    ) -> Union[Any, str]:
+        """Save a fitted model to disk and return a reference"""
+        if not self.enabled:
+            return model
+
+        filename = (
+            f"{name}_boot{boot_idx}.pkl" if boot_idx is not None else f"{name}.pkl"
+        )
+        filepath = self.dir / filename
+
+        joblib.dump(model, filepath, compress=self.compression)
+
+        return str(filepath)
+
+    def load_model(self, ref: Union[Any, str]) -> Any:
+        if not self.enabled or not isinstance(ref, str):
+            return ref
+
+        return joblib.load(ref)
+
+    def save_dataframe(self, df: pl.DataFrame, name: str) -> Union[pl.DataFrame, str]:
+        if not self.enabled:
+            return df
+
+        filename = f"{name}.parquet"
+        filepath = self.dir / filename
+
+        df.write_parquet(filepath, compression="zstd")
+
+        return str(filepath)
+
+    def load_dataframe(self, ref: Union[pl.DataFrame, str]) -> pl.DataFrame:
+        if not self.enabled or not isinstance(ref, str):
+            return ref
+
+        return pl.read_parquet(ref)

pySEQTarget/helpers/_predict_model.py

@@ -1,9 +1,57 @@
+import warnings
+
 import numpy as np
 
+from ._fix_categories import _fix_categories_for_predict
+
+
+def _safe_predict(model, data, clip_probs=True):
+    """
+    Predict with category fix fallback if needed.
+
+    Parameters
+    ----------
+    model : statsmodels model
+        Fitted model object
+    data : pandas DataFrame
+        Data to predict on
+    clip_probs : bool
+        If True, clip probabilities to [0, 1] and replace NaN with 0.5
+    """
+    data = data.copy()
+
+    try:
+        probs = model.predict(data)
+    except Exception as e:
+        if "mismatching levels" in str(e):
+            data = _fix_categories_for_predict(model, data)
+            probs = model.predict(data)
+        else:
+            raise
+
+    if clip_probs:
+        probs = np.array(probs)
+        if np.any(np.isnan(probs)):
+            warnings.warn("NaN values in predicted probabilities, replacing with 0.5")
+            probs = np.where(np.isnan(probs), 0.5, probs)
+        probs = np.clip(probs, 0, 1)
+
+    return probs
+
 
 def _predict_model(self, model, newdata):
     newdata = newdata.to_pandas()
+
+    # Original behavior - convert fixed_cols to category
     for col in self.fixed_cols:
         if col in newdata.columns:
             newdata[col] = newdata[col].astype("category")
-    return np.array(model.predict(newdata))
+
+    try:
+        return np.array(model.predict(newdata))
+    except Exception as e:
+        if "mismatching levels" in str(e):
+            newdata = _fix_categories_for_predict(model, newdata)
+            return np.array(model.predict(newdata))
+        else:
+            raise