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Allen Lynch committed Sep 3, 2020
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57 changes: 57 additions & 0 deletions docs/.ipynb_checkpoints/README-checkpoint.ipynb
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{
"cells": [
{
"cell_type": "markdown",
"metadata": {},
"source": [
"# LISA: Landscape In-Silico deletion Analysis\n",
"<hr>\n",
"\n",
"## About\n",
"\n",
"LISA predicts which TFs regulate a set of genes using integrative modeling of chromatin accessiblity and ChIP-seq binding. Particularly, LISA models the effects of deleting the influence of a TF on the expression of the genes-of-interest. For more information, see <a href=https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-1934-6>https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-1934-6</a>. This implementation extends the original, running 30x faster, reducing dependencies, and adding useful CLI functions for pipeline integration. "
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Requirements\n",
"\n",
"* python >= 3.6\n",
"* numpy, scipy, scikit-learn, and h5py\n",
"* ~15GB of storage space"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Installation\n",
"\n",
"LISA is available for install from PyPI. It is recommended that you set up a virtual environment using ```venv```, then run:"
]
}
],
"metadata": {
"kernelspec": {
"display_name": "lisa_test",
"language": "python",
"name": "lisa_test"
},
"language_info": {
"codemirror_mode": {
"name": "ipython",
"version": 3
},
"file_extension": ".py",
"mimetype": "text/x-python",
"name": "python",
"nbconvert_exporter": "python",
"pygments_lexer": "ipython3",
"version": "3.7.3"
}
},
"nbformat": 4,
"nbformat_minor": 4
}
125 changes: 0 additions & 125 deletions docs/README.ipynb

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1 change: 1 addition & 0 deletions setup.py
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'scikit-learn'
],
include_package_data=True,
python_requires='>=3.6',
)

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