diff --git a/pathways/WP5417/WP5417-bibliography.tsv b/pathways/WP5417/WP5417-bibliography.tsv new file mode 100644 index 000000000..5b546a520 --- /dev/null +++ b/pathways/WP5417/WP5417-bibliography.tsv @@ -0,0 +1,6 @@ +ID Database Citation +10.1016/j.neuro.2019.09.014 DOI "Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map. de Leeuw VC, Hessel EVS, Pennings JLA, Hodemaekers HM, Wackers PFK, van Oostrom CTM, et al. NeuroToxicology [Internet]. 2020 Jan;76:1–9. Available from: http://dx.doi.org/10.1016/j.neuro.2019.09.014 DOI" +10.1016/j.scr.2018.07.022 DOI "A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo. Spangler A, Su EY, Craft AM, Cahan P. Stem Cell Research [Internet]. 2018 Aug;31:201–15. Available from: http://dx.doi.org/10.1016/j.scr.2018.07.022 DOI" +10.1016/j.stem.2016.10.015 DOI "Neural Subtype Specification from Human Pluripotent Stem Cells. Tao Y, Zhang SC. Cell Stem Cell [Internet]. 2016 Nov;19(5):573–86. Available from: http://dx.doi.org/10.1016/j.stem.2016.10.015 DOI" +10.1038/s41586-018-0578-0 DOI "Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids. Beccari L, Moris N, Girgin M, Turner DA, Baillie-Johnson P, Cossy AC, et al. Nature [Internet]. 2018 Oct;562(7726):272–6. Available from: http://dx.doi.org/10.1038/s41586-018-0578-0 DOI" +10.14573/altex.2010.1.16 DOI "Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. Kuegler P. ALTEX [Internet]. 2010;16–41. Available from: http://dx.doi.org/10.14573/altex.2010.1.16 DOI" diff --git a/pathways/WP5417/WP5417-datanodes.tsv b/pathways/WP5417/WP5417-datanodes.tsv new file mode 100644 index 000000000..c4b3a9652 --- /dev/null +++ b/pathways/WP5417/WP5417-datanodes.tsv @@ -0,0 +1,135 @@ +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI +DPPA3 GeneProduct ensembl:ENSG00000187569 ensembl:ENSG00000187569 ncbigene:359787 hgnc.symbol:DPPA3 uniprot:Q6W0C5 +POU5F1 GeneProduct ensembl:ENSG00000204531 ensembl:ENSG00000204531 ncbigene:5460 hgnc.symbol:POU5F1 uniprot:M1S623;uniprot:Q01860;uniprot:D2IYK3;uniprot:F2Z381 +SOX2 GeneProduct ensembl:ENSG00000181449 ensembl:ENSG00000181449 ncbigene:6657 hgnc.symbol:SOX2 uniprot:A0A0U3FYV6;uniprot:P48431 +ZFP42 GeneProduct ensembl:ENSG00000179059 ensembl:ENSG00000179059 ncbigene:132625 hgnc.symbol:ZFP42 uniprot:Q96MM3 +HES1 GeneProduct ensembl:ENSG00000114315 ensembl:ENSG00000114315 ncbigene:3280 hgnc.symbol:HES1 uniprot:Q14469 +NOTCH1 GeneProduct ensembl:ENSG00000148400 ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:A0A7P0TAK8;uniprot:A0A7P0TBG2;uniprot:A0A7P0T8U6;uniprot:A0A7P0T9V1;uniprot:A0A7P0TA56;uniprot:P46531;uniprot:A0A7P0TB20;uniprot:A0A7P0T8W1;uniprot:A0A7P0Z4H9 +PECAM1 GeneProduct ensembl:ENSG00000261371 ensembl:ENSG00000261371 ncbigene:5175 hgnc.symbol:PECAM1 uniprot:A0A075B728;uniprot:A0A075B727;uniprot:A0A075B737;uniprot:P16284 +TBXT GeneProduct ensembl:ENSG00000164458 ensembl:ENSG00000164458 ncbigene:6862 hgnc.symbol:TBXT uniprot:O15178;uniprot:J3KP65;uniprot:H0YM91 +TPM1 GeneProduct ensembl:ENSG00000140416 ensembl:ENSG00000140416 ncbigene:7168 hgnc.symbol:TPM1 uniprot:A0A494BZZ2;uniprot:A0A494C0V8;uniprot:A0A0K0K1I0;uniprot:A0A0S2Z4G6;uniprot:H0YKX5;uniprot:H7BYY1;uniprot:A0A494C0I0;uniprot:B7Z596;uniprot:F5H7S3;uniprot:H0YL80;uniprot:H0YK48;uniprot:H0YKP3;uniprot:P09493;uniprot:H0YLS7;uniprot:A0A087WTJ7;uniprot:H0YL42;uniprot:A0A024R5W6;uniprot:D9YZV4;uniprot:Q6ZN40;uniprot:D9YZV5;uniprot:H0YKJ4;uniprot:D9YZV7;uniprot:H0YN06 +TNC GeneProduct ensembl:ENSG00000041982 ensembl:ENSG00000041982 ncbigene:3371 hgnc.symbol:TNC uniprot:F5H7V9;uniprot:H0YGZ3;uniprot:J3QSU6;uniprot:A0A0U1RR80;uniprot:E9PC84;uniprot:P24821;uniprot:F5H5D6 +ITGB1 GeneProduct ensembl:ENSG00000150093 ensembl:ENSG00000150093 ncbigene:3688 hgnc.symbol:ITGB1 uniprot:H7C4K3;uniprot:P05556;uniprot:A0A7I2V2F9;uniprot:E7EUI6;uniprot:C9JPK5;uniprot:C9JNE0;uniprot:E9PLR6;uniprot:Q5T3E4;uniprot:Q5T3E6;uniprot:Q5T3E5;uniprot:A0A7I2V2T4;uniprot:A0A7I2V5T3;uniprot:E7EQW5;uniprot:A0A7I2V5Z8;uniprot:E9PQJ2;uniprot:A0A7I2V348;uniprot:H7C4N8 +KRT15 GeneProduct ensembl:ENSG00000171346 ensembl:ENSG00000171346 ncbigene:3866 hgnc.symbol:KRT15 uniprot:C9JTG5;uniprot:K7EQK9;uniprot:A8MT21;uniprot:P19012;uniprot:K7EMX0 +ITGA6 GeneProduct ensembl:ENSG00000091409 ensembl:ENSG00000091409 ncbigene:3655 hgnc.symbol:ITGA6 uniprot:H7BZ97;uniprot:P23229;uniprot:A0A8C8KBL6;uniprot:C9JXX7 +MSX2 GeneProduct ensembl:ENSG00000120149 ensembl:ENSG00000120149 ncbigene:4488 hgnc.symbol:MSX2 uniprot:D6RIS4;uniprot:P35548 +NGFR GeneProduct ensembl:ENSG00000064300 ensembl:ENSG00000064300 ncbigene:4804 hgnc.symbol:NGFR uniprot:P08138 +PAX3 GeneProduct ensembl:ENSG00000135903 ensembl:ENSG00000135903 ncbigene:5077 hgnc.symbol:PAX3 uniprot:P23760 +ROBO1 GeneProduct ensembl:ENSG00000169855 ensembl:ENSG00000169855 ncbigene:6091 hgnc.symbol:ROBO1 uniprot:F8WEV8;uniprot:Q9Y6N7;uniprot:H7C545;uniprot:A0A0A0MSX4;uniprot:H7C4Y7;uniprot:A0A087WZ85 +SOX10 GeneProduct ensembl:ENSG00000100146 ensembl:ENSG00000100146 ncbigene:6663 hgnc.symbol:SOX10 uniprot:A0A494C0R1;uniprot:H0Y5N4;uniprot:P56693;uniprot:A6PVD3;uniprot:A0A024R1N6 +SOX9 GeneProduct ensembl:ENSG00000125398 ensembl:ENSG00000125398 ncbigene:6662 hgnc.symbol:SOX9 uniprot:P48436 +TWIST1 GeneProduct ensembl:ENSG00000122691 ensembl:ENSG00000122691 ncbigene:7291 hgnc.symbol:TWIST1 uniprot:H7BY00;uniprot:H7C4D7;uniprot:Q15672 +TWIST2 GeneProduct ensembl:ENSG00000233608 ensembl:ENSG00000233608 ncbigene:117581 hgnc.symbol:TWIST2 uniprot:A1MB48;uniprot:Q8WVJ9 +SNAI1 GeneProduct ensembl:ENSG00000124216 ensembl:ENSG00000124216 ncbigene:6615 hgnc.symbol:SNAI1 uniprot:O95863 +SNAI2 GeneProduct ensembl:ENSG00000019549 ensembl:ENSG00000019549 ncbigene:6591 hgnc.symbol:SNAI2 uniprot:A0A1X7SC17;uniprot:O43623 +SLC1A2 GeneProduct ensembl:ENSG00000110436 ensembl:ENSG00000110436 ncbigene:6506 hgnc.symbol:SLC1A2 uniprot:A0A2R8YH93;uniprot:A0A2R8Y4D1;uniprot:A0A2R8Y6J5;uniprot:A0A2U3TZS7;uniprot:A0A2U3U0E3;uniprot:A0A2R8YD46;uniprot:A0A2R8YG01;uniprot:P43004;uniprot:A0A2R8Y4W1;uniprot:A0A2R8YCL7;uniprot:A2A2U1;uniprot:H0YEK4;uniprot:A0A2R8Y5Y1;uniprot:A0A2R8Y6B8;uniprot:A0A2R8Y740;uniprot:A0A2R8YHI4;uniprot:A0A2R8Y860;uniprot:C9J9N5;uniprot:A0A2R8Y4N0;uniprot:A0A163QEF0;uniprot:A0A2R8Y642;uniprot:A0A2R8Y862;uniprot:A0A2R8YFE3;uniprot:H0YEB1 +SLC1A3 GeneProduct ensembl:ENSG00000079215 ensembl:ENSG00000079215 ncbigene:6507 hgnc.symbol:SLC1A3 uniprot:A0A087X0U3;uniprot:A0A7P0T8P5;uniprot:A0A7P0TB50;uniprot:A0A7P0T911;uniprot:A0A7P0T8R2;uniprot:A0A7P0T8T4;uniprot:A0A7P0T9P1;uniprot:A0A7P0T8H5;uniprot:A0A7P0Z4F7;uniprot:A0A7P0Z4R4;uniprot:Q7Z5T0;uniprot:A0A7P0T9A4;uniprot:E7EUS7;uniprot:A0A7P0T9Z4;uniprot:A0A7P0TAG7;uniprot:A0A7P0T7Q9;uniprot:A0A7P0T807;uniprot:A0A7P0TAW2;uniprot:A0A7P0T800;uniprot:A0A7P0T8Q1;uniprot:P43003;uniprot:A0A7P0TA03;uniprot:A0A024R050;uniprot:E7EUV6;uniprot:A0A087WT87;uniprot:A0A7P0TAF5 +S100B GeneProduct ensembl:ENSG00000160307 ensembl:ENSG00000160307 ncbigene:6285 hgnc.symbol:S100B uniprot:P04271;uniprot:A0A0S2Z4C5;uniprot:A8MRB1 +CSPG4 GeneProduct ensembl:ENSG00000173546 ensembl:ENSG00000173546 ncbigene:1464 hgnc.symbol:CSPG4 uniprot:Q6UVK1 +MBP GeneProduct ensembl:ENSG00000197971 ensembl:ENSG00000197971 ncbigene:4155 hgnc.symbol:MBP uniprot:F5H7N4;uniprot:E9PJ72;uniprot:E9PNZ1;uniprot:P02686;uniprot:E9PKX9;uniprot:E9PLU9;uniprot:E9PMR5;uniprot:H0YF02;uniprot:E9PLQ9;uniprot:J3QL64;uniprot:J3KS94;uniprot:F8WEU6;uniprot:A0A024R384;uniprot:J3QKL5;uniprot:C9J6H1;uniprot:J3QKN5;uniprot:A8MZH3;uniprot:E9PSE2;uniprot:H0YEA2;uniprot:J3KT01;uniprot:J3KT34;uniprot:E9PQE7;uniprot:H7BYR8;uniprot:J3QQK6 +MOG GeneProduct ensembl:ENSG00000204655 ensembl:ENSG00000204655 ncbigene:4340 hgnc.symbol:MOG uniprot:E9PG44;uniprot:H7BYC0;uniprot:C9JTE0;uniprot:H0Y8A0;uniprot:Q16653 +OLIG2 GeneProduct ensembl:ENSG00000205927 ensembl:ENSG00000205927 ncbigene:10215 hgnc.symbol:OLIG2 uniprot:C9J444;uniprot:Q13516 +LIN7A GeneProduct ensembl:ENSG00000111052 ensembl:ENSG00000111052 ncbigene:8825 hgnc.symbol:LIN7A uniprot:H0YIA8;uniprot:J3KN23;uniprot:O14910;uniprot:H0YI92 +RIMS2 GeneProduct ensembl:ENSG00000176406 ensembl:ENSG00000176406 ncbigene:9699 hgnc.symbol:RIMS2 uniprot:A0A590UJL1;uniprot:D6RDY0;uniprot:Q9UQ26;uniprot:F8W6W8;uniprot:D6RA03;uniprot:A0A590UK62;uniprot:E5RI36;uniprot:A0A0J9YWD4;uniprot:A0A0J9YXG4 +SYP GeneProduct ensembl:ENSG00000102003 ensembl:ENSG00000102003 ncbigene:6855 hgnc.symbol:SYP uniprot:F2Z3E1;uniprot:G5E9A2;uniprot:P08247;uniprot:H7C4W3 +DLG4 GeneProduct ensembl:ENSG00000132535 ensembl:ENSG00000132535 ncbigene:1742 hgnc.symbol:DLG4 uniprot:B7Z647;uniprot:B7Z3U2;uniprot:P78352;uniprot:A0A3B3ITI9;uniprot:B9EGL1;uniprot:A0A3B3ITD1;uniprot:K7EKP9;uniprot:K7EKU8;uniprot:A0A3B3IU19;uniprot:O14909;uniprot:A0A3B3ISL1;uniprot:C9JWP9;uniprot:A0A3B3IS17;uniprot:A0A3B3ISQ5;uniprot:A0A3B3IRP2;uniprot:C9JYG3;uniprot:A0A3B3ISR0 +HOMER2 GeneProduct ensembl:ENSG00000103942 ensembl:ENSG00000103942 ncbigene:9455 hgnc.symbol:HOMER2 uniprot:Q9NSB8;uniprot:H0YNR9 +SLC17A6 GeneProduct ensembl:ENSG00000091664 ensembl:ENSG00000091664 ncbigene:57084 hgnc.symbol:SLC17A6 uniprot:Q9P2U8 +SLC6A1 GeneProduct ensembl:ENSG00000157103 ensembl:ENSG00000157103 ncbigene:6529 hgnc.symbol:SLC6A1 uniprot:A0A2R8Y4I3;uniprot:A0A024R2K8;uniprot:A0A2R8YF74;uniprot:A0A2R8YCM3;uniprot:A0A2R8YEF0;uniprot:A0A2R8Y3X2;uniprot:A0A2R8YFI0;uniprot:C9J5P8;uniprot:A0A2R8Y495;uniprot:A0A2R8YDD5;uniprot:B7Z3C5;uniprot:A0A2R8Y867;uniprot:P30531 +GAD1 GeneProduct ensembl:ENSG00000128683 ensembl:ENSG00000128683 ncbigene:2571 hgnc.symbol:GAD1 uniprot:C9JT43;uniprot:U3KQR2;uniprot:C9JN45;uniprot:C9JLZ7;uniprot:C9J6C9;uniprot:A0A0S2Z3V5;uniprot:Q99259;uniprot:F8WD43 +GAD2 GeneProduct ensembl:ENSG00000136750 ensembl:ENSG00000136750 ncbigene:2572 hgnc.symbol:GAD2 uniprot:A0A3B3IU09;uniprot:Q5VZ30;uniprot:Q05329;uniprot:Q5VZ31 +GLRB GeneProduct ensembl:ENSG00000109738 ensembl:ENSG00000109738 ncbigene:2743 hgnc.symbol:GLRB uniprot:P48167;uniprot:D6R9Y9;uniprot:D6RD86 +SLC6A5 GeneProduct ensembl:ENSG00000165970 ensembl:ENSG00000165970 ncbigene:9152 hgnc.symbol:SLC6A5 uniprot:Q9Y345;uniprot:J3KNC4 +SLC18A3 GeneProduct ensembl:ENSG00000187714 ensembl:ENSG00000187714 ncbigene:6572 hgnc.symbol:SLC18A3 uniprot:Q16572 +TH GeneProduct ensembl:ENSG00000180176 ensembl:ENSG00000180176 ncbigene:7054 hgnc.symbol:TH uniprot:H0Y670;uniprot:F8W8M5;uniprot:H0Y677;uniprot:E7EQI0;uniprot:P07101 +SLC6A3 GeneProduct ensembl:ENSG00000142319 ensembl:ENSG00000142319 ncbigene:6531 hgnc.symbol:SLC6A3 uniprot:Q01959 +SLC6A2 GeneProduct ensembl:ENSG00000103546 ensembl:ENSG00000103546 ncbigene:6530 hgnc.symbol:SLC6A2 uniprot:A0A024R6T9;uniprot:H3BML6;uniprot:H3BRE9;uniprot:A0A804HLI4;uniprot:H3BM11;uniprot:H3BRS0;uniprot:P23975 +ADRA2B GeneProduct ensembl:ENSG00000274286 ensembl:ENSG00000274286 ncbigene:151 hgnc.symbol:ADRA2B uniprot:P18089 +TPH1 GeneProduct ensembl:ENSG00000129167 ensembl:ENSG00000129167 ncbigene:7166 hgnc.symbol:TPH1 uniprot:E9PR49;uniprot:E7EMX4;uniprot:P17752 +SLC6A4 GeneProduct ensembl:ENSG00000108576 ensembl:ENSG00000108576 ncbigene:6532 hgnc.symbol:SLC6A4 uniprot:P31645;uniprot:J3QKP3;uniprot:J3KPR9 +CLDN11 GeneProduct ensembl:ENSG00000013297 ensembl:ENSG00000013297 ncbigene:5010 hgnc.symbol:CLDN11 uniprot:O75508 +GPHN GeneProduct ensembl:ENSG00000171723 ensembl:ENSG00000171723 ncbigene:10243 hgnc.symbol:GPHN uniprot:G3V582;uniprot:G3V4D2;uniprot:G3V4R0;uniprot:H0YJR5;uniprot:Q9NQX3;uniprot:H0YJ30;uniprot:G3V355;uniprot:F5H039;uniprot:H0YIY4 +CHAT GeneProduct ensembl:ENSG00000070748 ensembl:ENSG00000070748 ncbigene:1103 hgnc.symbol:CHAT uniprot:P28329;uniprot:R4GN13;uniprot:A0A1W2PRG4;uniprot:A0A1W2PP46 +SHANK3 GeneProduct ensembl:ENSG00000251322 ensembl:ENSG00000251322 ncbigene:85358 hgnc.symbol:SHANK3 uniprot:A0A669KBA8;uniprot:A0A0U1RQS4;uniprot:A0A669K9V7;uniprot:A0A590UJL3;uniprot:A0A590UJY5;uniprot:A0A0U1RR93 +GRIN2B GeneProduct ensembl:ENSG00000273079 ensembl:ENSG00000273079 ncbigene:2904 hgnc.symbol:GRIN2B uniprot:A0A0D9SFA0;uniprot:A0A1B0GU78;uniprot:A0A8D9PHB2;uniprot:Q13224;uniprot:A0A0D9SFK0 +ACHE GeneProduct ensembl:ENSG00000087085 ensembl:ENSG00000087085 ncbigene:43 hgnc.symbol:ACHE uniprot:C9J2S3;uniprot:C9JZL6;uniprot:F8WAR7;uniprot:F8WD68;uniprot:P22303;uniprot:A0A498U6H7;uniprot:F8WD34;uniprot:C9JD78 +SNAP25 GeneProduct ensembl:ENSG00000132639 ensembl:ENSG00000132639 ncbigene:6616 hgnc.symbol:SNAP25 uniprot:P60880;uniprot:A0A0A0MSS0 +NODAL GeneProduct ensembl:ENSG00000156574 ensembl:ENSG00000156574 ncbigene:4838 hgnc.symbol:NODAL uniprot:Q96S42;uniprot:H7C0E4 +ALDH1L1 GeneProduct ensembl:ENSG00000144908 ensembl:ENSG00000144908 ncbigene:10840 hgnc.symbol:ALDH1L1 uniprot:O75891;uniprot:C9IZ36;uniprot:F2Z324;uniprot:C9JY00;uniprot:D6RFJ7;uniprot:A0A0S2Z586;uniprot:C9JYZ6;uniprot:F8WC34 +GLRA2 GeneProduct ensembl:ENSG00000101958 ensembl:ENSG00000101958 ncbigene:2742 hgnc.symbol:GLRA2 uniprot:C9JBL4;uniprot:P23416 +NANOG GeneProduct ensembl:ENSG00000111704 ensembl:ENSG00000111704 ncbigene:79923 hgnc.symbol:NANOG uniprot:Q9H9S0;uniprot:F5GZI2 +HTR1A GeneProduct ensembl:ENSG00000178394 ensembl:ENSG00000178394 ncbigene:3350 hgnc.symbol:HTR1A uniprot:D6RA34;uniprot:Q5ZGX3;uniprot:P08908 +RBFOX3 GeneProduct ensembl:ENSG00000167281 ensembl:ENSG00000167281 ncbigene:146713 hgnc.symbol:RBFOX3 uniprot:A0A3B3ITL7;uniprot:K7EQK7;uniprot:J3QRF4;uniprot:A6NFN3;uniprot:K7EJX6;uniprot:K7ESF7;uniprot:J3QQZ2 +SOX17 GeneProduct ensembl:ENSG00000164736 ensembl:ENSG00000164736 ncbigene:64321 hgnc.symbol:SOX17 uniprot:Q9H6I2 +GABBR1 GeneProduct ensembl:ENSG00000204681 ensembl:ENSG00000204681 ncbigene:2550 hgnc.symbol:GABBR1 uniprot:Q9UBS5;uniprot:C9J342;uniprot:F8WAV2;uniprot:F8WF38;uniprot:F8WDC0;uniprot:C9JZG6;uniprot:Q5SUJ9;uniprot:F8WAS6;uniprot:A0A1U9X7R0 +MIXL1 GeneProduct ensembl:ENSG00000185155 ensembl:ENSG00000185155 ncbigene:83881 hgnc.symbol:MIXL1 uniprot:A0A024R3T7;uniprot:Q9H2W2 +ERAS GeneProduct ensembl:ENSG00000187682 ensembl:ENSG00000187682 ncbigene:3266 hgnc.symbol:ERAS uniprot:Q7Z444 +KCNJ6 GeneProduct ensembl:ENSG00000157542 ensembl:ENSG00000157542 ncbigene:3763 hgnc.symbol:KCNJ6 uniprot:P48051 +ESRRB GeneProduct ensembl:ENSG00000119715 ensembl:ENSG00000119715 ncbigene:2103 hgnc.symbol:ESRRB uniprot:A0A2R8Y509;uniprot:E7EWD9;uniprot:A0A2R8Y491;uniprot:O95718 +CASK GeneProduct ensembl:ENSG00000147044 ensembl:ENSG00000147044 ncbigene:8573 hgnc.symbol:CASK uniprot:A0A2R8Y4K4;uniprot:A0A2U3TZM1;uniprot:Q5JS79;uniprot:A0A2R8YE77;uniprot:A0A7I2RJN6;uniprot:A0A2R8Y3B3;uniprot:A0A2R8Y6D8;uniprot:A0A2R8Y6F8;uniprot:A0A2R8Y472;uniprot:A0A2R8YEK3;uniprot:A0A2R8YFN5;uniprot:A0A2R8YEJ7;uniprot:O14936;uniprot:A0A2R8YGH2;uniprot:A0A2R8Y7X6;uniprot:A0A2U3TZN6;uniprot:A0A2U3TZM4 +PCLO GeneProduct ensembl:ENSG00000186472 ensembl:ENSG00000186472 ncbigene:27445 hgnc.symbol:PCLO uniprot:Q9Y6V0;uniprot:H7C114;uniprot:E9PE96;uniprot:H7C261 +ADRA2C GeneProduct ensembl:ENSG00000184160 ensembl:ENSG00000184160 ncbigene:152 hgnc.symbol:ADRA2C uniprot:P18825;uniprot:D6RGL0;uniprot:Q4W594 +NES GeneProduct ensembl:ENSG00000132688 ensembl:ENSG00000132688 ncbigene:10763 hgnc.symbol:NES uniprot:P48681 +LEF1 GeneProduct ensembl:ENSG00000138795 ensembl:ENSG00000138795 ncbigene:51176 hgnc.symbol:LEF1 uniprot:D6RID7;uniprot:D6RAB1;uniprot:D6RIV1;uniprot:Q9UJU2 +PPFIA1 GeneProduct ensembl:ENSG00000131626 ensembl:ENSG00000131626 ncbigene:8500 hgnc.symbol:PPFIA1 uniprot:E9PJZ7;uniprot:H0YD72;uniprot:H0YDW2;uniprot:A0A2R8Y7R9;uniprot:A0A1B0GVT3;uniprot:Q13136;uniprot:H0YDZ8;uniprot:H0YD39;uniprot:H0YEK0;uniprot:H0YF15;uniprot:E9PID5;uniprot:E9PPF6;uniprot:H0YEF9;uniprot:A0A3B3ITS2 +FABP7 GeneProduct ensembl:ENSG00000164434 ensembl:ENSG00000164434 ncbigene:2173 hgnc.symbol:FABP7 uniprot:O15540 +HOMER3 GeneProduct ensembl:ENSG00000051128 ensembl:ENSG00000051128 ncbigene:9454 hgnc.symbol:HOMER3 uniprot:M0R2T8;uniprot:M0R2U7;uniprot:M0QZN1;uniprot:Q9NSC5;uniprot:M0QYF9 +NLGN1 GeneProduct ensembl:ENSG00000169760 ensembl:ENSG00000169760 ncbigene:22871 hgnc.symbol:NLGN1 uniprot:C9J4D3;uniprot:Q8N2Q7;uniprot:A0A1D5RMP7;uniprot:C9JWG7 +ERC1 GeneProduct ensembl:ENSG00000082805 ensembl:ENSG00000082805 ncbigene:23085 hgnc.symbol:ERC1 uniprot:G8JLD3;uniprot:Q8IUD2;uniprot:X6RLX0;uniprot:K7EKH8;uniprot:X6RM00;uniprot:K7EIZ7;uniprot:K7EPP6;uniprot:K7EPD6;uniprot:K7EP25 +UNC13A GeneProduct ensembl:ENSG00000130477 ensembl:ENSG00000130477 ncbigene:23025 hgnc.symbol:UNC13A uniprot:F8W0P6;uniprot:Q9UPW8;uniprot:F8VZH8;uniprot:F8W059 +FOXA2 GeneProduct ensembl:ENSG00000125798 ensembl:ENSG00000125798 ncbigene:3170 hgnc.symbol:FOXA2 uniprot:B0ZTD4;uniprot:Q9Y261 +LMX1B GeneProduct ensembl:ENSG00000136944 ensembl:ENSG00000136944 ncbigene:4010 hgnc.symbol:LMX1B uniprot:O60663 +NEFL GeneProduct ensembl:ENSG00000277586 ensembl:ENSG00000277586 ncbigene:4747 hgnc.symbol:NEFL uniprot:P07196 +GFAP GeneProduct ensembl:ENSG00000131095 ensembl:ENSG00000131095 ncbigene:2670 hgnc.symbol:GFAP uniprot:A0A0G2JLI8;uniprot:K7EKH9;uniprot:K7EPI4;uniprot:K7EKD1;uniprot:A0A1X7SBR3;uniprot:K7EPT8;uniprot:A0A1W2PPA3;uniprot:K7ELP4;uniprot:P14136;uniprot:K7EJK1;uniprot:A0A1W2PPF0;uniprot:A0A1W2PQ25;uniprot:A0A1W2PR46;uniprot:A0A1X7SCE1;uniprot:A0A1W2PQU7;uniprot:K7EJU1;uniprot:A0A1W2PPL2;uniprot:A0A1W2PS58;uniprot:B4DIR1;uniprot:A0A1W2PP21;uniprot:A0A1W2PQS4;uniprot:A0A1W2PRT3 +HOMER1 GeneProduct ensembl:ENSG00000152413 ensembl:ENSG00000152413 ncbigene:9456 hgnc.symbol:HOMER1 uniprot:Q86YM6;uniprot:Q86YM7 +GATA4 GeneProduct ensembl:ENSG00000136574 ensembl:ENSG00000136574 ncbigene:2626 hgnc.symbol:GATA4 uniprot:E9PKS4;uniprot:R4GND5;uniprot:B6DU75;uniprot:A0A087WZ09;uniprot:P43694;uniprot:B3KUF4 +GRIN1 GeneProduct ensembl:ENSG00000176884 ensembl:ENSG00000176884 ncbigene:2902 hgnc.symbol:GRIN1 uniprot:A2AVK2;uniprot:Q05586;uniprot:Q5VSF9 +NEFM GeneProduct ensembl:ENSG00000104722 ensembl:ENSG00000104722 ncbigene:4741 hgnc.symbol:NEFM uniprot:E7ESP9;uniprot:P07197;uniprot:E7EMV2 +NR4A2 GeneProduct ensembl:ENSG00000153234 ensembl:ENSG00000153234 ncbigene:4929 hgnc.symbol:NR4A2 uniprot:C9IYM5;uniprot:E9PBQ4;uniprot:F1DAL2;uniprot:F8W6I3;uniprot:P43354;uniprot:C9J8W4;uniprot:F1D8N6;uniprot:C9JWQ1 +GLS GeneProduct ensembl:ENSG00000115419 ensembl:ENSG00000115419 ncbigene:2744 hgnc.symbol:GLS uniprot:B8ZZC5;uniprot:H7BZD1;uniprot:H7C201;uniprot:B7Z509;uniprot:O94925;uniprot:C9JIJ6;uniprot:B8ZZA8 +GLRA4 GeneProduct ensembl:ENSG00000188828 ensembl:ENSG00000188828 hgnc.symbol:GLRA4 +PAX6 GeneProduct ensembl:ENSG00000007372 ensembl:ENSG00000007372 ncbigene:5080 hgnc.symbol:PAX6 uniprot:A0A1W2PS91;uniprot:A0A1W2PQA8;uniprot:A0A1W2PSA8;uniprot:A0A1W2PRA8;uniprot:A0A1X7SBT0;uniprot:A0A1W2PRA4;uniprot:A0A1W2PQG7;uniprot:A0A1W2PPG3;uniprot:A0A1W2PQM7;uniprot:Q66SS1;uniprot:A0A1W2PRG3;uniprot:A0A1W2PQG3;uniprot:A0A1W2PPM5;uniprot:B1B1J0;uniprot:D1KF47;uniprot:A0A1W2PP27;uniprot:A0A1W2PRS6;uniprot:A0A1W2PNS7;uniprot:A0A1W2PRW7;uniprot:A0A1W2PP89;uniprot:A0A1W2PRU4;uniprot:A0A1W2PQW3;uniprot:B1B1I8;uniprot:B1B1I9;uniprot:A0A1W2PSB5;uniprot:E9PKM0;uniprot:A0A1W2PRH6;uniprot:A0A1W2PQJ8;uniprot:P26367;uniprot:A0A1W2PQL7;uniprot:A0A1W2PPH0;uniprot:A0A1W2PPJ2;uniprot:F1T0F8;uniprot:A0A1W2PPN2;uniprot:A0A1W2PR58;uniprot:A0A1W2PQ31 +KLF4 GeneProduct ensembl:ENSG00000136826 ensembl:ENSG00000136826 ncbigene:9314 hgnc.symbol:KLF4 uniprot:O43474;uniprot:A0A087X0S4;uniprot:B7ZBT2 +AP2A2 GeneProduct ensembl:ENSG00000183020 ensembl:ENSG00000183020 ncbigene:161 hgnc.symbol:AP2A2 uniprot:H0YEG0;uniprot:E9PQP4;uniprot:E9PPZ3;uniprot:O94973;uniprot:E9PPY8;uniprot:E9PR62;uniprot:E9PS94;uniprot:H0YDE9 +BSN GeneProduct ensembl:ENSG00000164061 ensembl:ENSG00000164061 ncbigene:8927 hgnc.symbol:BSN uniprot:Q9UPA5 +CDH2 GeneProduct ensembl:ENSG00000170558 ensembl:ENSG00000170558 ncbigene:1000 hgnc.symbol:CDH2 uniprot:A0A6Q8PG20;uniprot:P19022;uniprot:A0A024RC42;uniprot:A0A6Q8PF58;uniprot:A0A6Q8PHJ8;uniprot:C9J8J8;uniprot:C9J126;uniprot:C9JMH2 +HNF4A GeneProduct ensembl:ENSG00000101076 ensembl:ENSG00000101076 ncbigene:3172 hgnc.symbol:HNF4A uniprot:A0A804HIR4;uniprot:A0A804HI58;uniprot:A0A804HJ41;uniprot:A0A804HJL7;uniprot:A0A804HJJ6;uniprot:P41235;uniprot:F1D8T0;uniprot:F1D8T1;uniprot:F8WBS7;uniprot:B9VVT8;uniprot:F1D8S2;uniprot:A0A804HJ81;uniprot:A0A087WXV4 +LHX1 GeneProduct ensembl:ENSG00000273706 ensembl:ENSG00000273706 ncbigene:3975 hgnc.symbol:LHX1 uniprot:A0A087WY40;uniprot:P48742 +FEV GeneProduct ensembl:ENSG00000163497 ensembl:ENSG00000163497 ncbigene:54738 hgnc.symbol:FEV uniprot:Q99581 +CNP GeneProduct ensembl:ENSG00000173786 ensembl:ENSG00000173786 ncbigene:1267 hgnc.symbol:CNP uniprot:K7EN66;uniprot:A0A024R1T5;uniprot:K7ERZ0;uniprot:K7EQ27;uniprot:C9K0L8;uniprot:K7ERC4;uniprot:P09543 +GLRA3 GeneProduct ensembl:ENSG00000145451 ensembl:ENSG00000145451 ncbigene:8001 hgnc.symbol:GLRA3 uniprot:O75311 +DLL1 GeneProduct ensembl:ENSG00000198719 ensembl:ENSG00000198719 ncbigene:28514 hgnc.symbol:DLL1 uniprot:A0A0D9SF76;uniprot:A0A384P5C6;uniprot:O00548 +EVX1 GeneProduct ensembl:ENSG00000106038 ensembl:ENSG00000106038 ncbigene:2128 hgnc.symbol:EVX1 uniprot:J3QQJ1;uniprot:P49640;uniprot:F8W9J5 +AQP4 GeneProduct ensembl:ENSG00000171885 ensembl:ENSG00000171885 ncbigene:361 hgnc.symbol:AQP4 uniprot:V9PBN7;uniprot:H0Y3H5;uniprot:P55087;uniprot:A0A5F9ZHR4;uniprot:J3KRM4;uniprot:F1DSG4 +SHANK1 GeneProduct ensembl:ENSG00000161681 ensembl:ENSG00000161681 ncbigene:50944 hgnc.symbol:SHANK1 uniprot:H9KV90;uniprot:Q9Y566;uniprot:M0QYB5 +AP2A1 GeneProduct ensembl:ENSG00000196961 ensembl:ENSG00000196961 ncbigene:160 hgnc.symbol:AP2A1 uniprot:M0R2D9;uniprot:O95782 +FOXA2 GeneProduct ensembl:ENSG00000125798 ensembl:ENSG00000125798 ncbigene:3170 hgnc.symbol:FOXA2 uniprot:B0ZTD4;uniprot:Q9Y261 +GLRA1 GeneProduct ensembl:ENSG00000145888 ensembl:ENSG00000145888 ncbigene:2741 hgnc.symbol:GLRA1 uniprot:E5RJ70;uniprot:P23415 +DLG3 GeneProduct ensembl:ENSG00000082458 ensembl:ENSG00000082458 ncbigene:1741 hgnc.symbol:DLG3 uniprot:Q5JUW8;uniprot:Q92796 +HES5 GeneProduct ensembl:ENSG00000197921 ensembl:ENSG00000197921 ncbigene:388585 hgnc.symbol:HES5 uniprot:Q5TA89 +CACNG2 GeneProduct ensembl:ENSG00000166862 ensembl:ENSG00000166862 ncbigene:10369 hgnc.symbol:CACNG2 uniprot:Q9Y698 +DCX GeneProduct ensembl:ENSG00000077279 ensembl:ENSG00000077279 ncbigene:1641 hgnc.symbol:DCX uniprot:E7EU50;uniprot:A0A1B0GWD1;uniprot:A0A7P0T9C5;uniprot:A0A804CF28;uniprot:A8K340;uniprot:O43602 +CDH1 GeneProduct ensembl:ENSG00000039068 ensembl:ENSG00000039068 ncbigene:999 hgnc.symbol:CDH1 uniprot:H3BVI7;uniprot:P12830;uniprot:H3BNC6;uniprot:A0A0U2ZQU7;uniprot:J3QKP1 +SLC17A7 GeneProduct ensembl:ENSG00000104888 ensembl:ENSG00000104888 ncbigene:57030 hgnc.symbol:SLC17A7 uniprot:M0R1S5;uniprot:Q9P2U7 +CD24 GeneProduct ensembl:ENSG00000272398 ensembl:ENSG00000272398 ncbigene:100133941 hgnc.symbol:CD24 uniprot:P25063;uniprot:A0A087WU21;uniprot:A0A087WU87;uniprot:A0A087WW33 +SLC6A9 GeneProduct ensembl:ENSG00000196517 ensembl:ENSG00000196517 ncbigene:6536 hgnc.symbol:SLC6A9 uniprot:P48067;uniprot:B7Z589;uniprot:B7Z3A9;uniprot:E9PJ65;uniprot:J3KPA5;uniprot:E9PLM5 +MSX1 GeneProduct ensembl:ENSG00000163132 ensembl:ENSG00000163132 ncbigene:4487 hgnc.symbol:MSX1 uniprot:P28360 +FOXD3 GeneProduct ensembl:ENSG00000187140 ensembl:ENSG00000187140 ncbigene:27022 hgnc.symbol:FOXD3 uniprot:Q9UJU5 +DLG2 GeneProduct ensembl:ENSG00000150672 ensembl:ENSG00000150672 ncbigene:1740 hgnc.symbol:DLG2 uniprot:A0A3B3ISW2;uniprot:A8MUT9;uniprot:Q6ZSU2;uniprot:E9PN83;uniprot:H7C325;uniprot:Q15700;uniprot:C9JFF9;uniprot:E9PRX3;uniprot:A0A3B3ITF4;uniprot:E9PPV7;uniprot:B7Z2T4;uniprot:F8W750;uniprot:A0A3B3ITF1;uniprot:A8MVA8;uniprot:E9PIJ9;uniprot:E9PRL2;uniprot:F8VYC1;uniprot:E9PQT9;uniprot:B5MCC5;uniprot:E9PIW2;uniprot:A0A5F9ZH92 +GABBR2 GeneProduct ensembl:ENSG00000136928 ensembl:ENSG00000136928 ncbigene:9568 hgnc.symbol:GABBR2 uniprot:H9NIL8;uniprot:A0A0U1RR59;uniprot:A0A1B0GW60;uniprot:O75899 +FBXO15 GeneProduct ensembl:ENSG00000141665 ensembl:ENSG00000141665 ncbigene:201456 hgnc.symbol:FBXO15 uniprot:J3QL50;uniprot:J3QKV0;uniprot:J3KRT3;uniprot:J3QRE7;uniprot:J3KS84;uniprot:J3QLF9;uniprot:J3KRS5;uniprot:Q8NCQ5;uniprot:A0A3B3IRP1;uniprot:J3KRQ6 +GLUL GeneProduct ensembl:ENSG00000135821 ensembl:ENSG00000135821 ncbigene:2752 hgnc.symbol:GLUL uniprot:P15104;uniprot:A0A2R8YDT1;uniprot:A8YXX4 +TBR1 GeneProduct ensembl:ENSG00000136535 ensembl:ENSG00000136535 ncbigene:10716 hgnc.symbol:TBR1 uniprot:H7C0B1;uniprot:Q16650 +RIMBP2 GeneProduct ensembl:ENSG00000060709 ensembl:ENSG00000060709 ncbigene:23504 hgnc.symbol:RIMBP2 uniprot:A0A2R8YFN7;uniprot:O15034;uniprot:A0A2R8Y6Z0;uniprot:A0A2R8YF94;uniprot:H0YFN4;uniprot:A0A2R8Y5H8;uniprot:A0A2U3TZP8 +BMP4 GeneProduct ensembl:ENSG00000125378 ensembl:ENSG00000125378 ncbigene:652 hgnc.symbol:BMP4 uniprot:H0YM53;uniprot:P12644;uniprot:Q53XC5;uniprot:V9GYF1;uniprot:H0YMP9;uniprot:H0YLW3 +HES3 GeneProduct ensembl:ENSG00000173673 ensembl:ENSG00000173673 ncbigene:390992 hgnc.symbol:HES3 uniprot:Q5TGS1 +DPPA2 GeneProduct ensembl:ENSG00000163530 ensembl:ENSG00000163530 ncbigene:151871 hgnc.symbol:DPPA2 uniprot:Q7Z7J5 +HTR5A GeneProduct ensembl:ENSG00000157219 ensembl:ENSG00000157219 ncbigene:3361 hgnc.symbol:HTR5A uniprot:A0A3B3ISH0;uniprot:A4D2N2;uniprot:P47898 +TUBB3 GeneProduct ensembl:ENSG00000258947 ensembl:ENSG00000258947 ncbigene:10381 hgnc.symbol:TUBB3 uniprot:G3V3J6;uniprot:G3V5W4;uniprot:G3V4U2;uniprot:G3V2A3;uniprot:G3V3W7;uniprot:G3V542;uniprot:G3V3R4;uniprot:G3V2R8;uniprot:G3V2N6;uniprot:Q13509 +DLG1 GeneProduct ensembl:ENSG00000075711 ensembl:ENSG00000075711 ncbigene:1739 hgnc.symbol:DLG1 uniprot:A0A590UJD9;uniprot:A0A590UJ81;uniprot:C9JUA9;uniprot:A0A590UK48;uniprot:A0A590UJ68;uniprot:A0A590UJ25;uniprot:A0A590UK02;uniprot:A0A590UJ08;uniprot:A0A590UJS9;uniprot:A0A590UJ29;uniprot:C9JN61;uniprot:A0A590UK81;uniprot:A0A0C4DFT3;uniprot:A0A590UJ64;uniprot:A0A590UJ86;uniprot:Q12959;uniprot:A0A590UJC5;uniprot:A0A590UKA8;uniprot:C9J110;uniprot:A8MUT6;uniprot:F2Z2L0;uniprot:E7EQD7;uniprot:H7C166;uniprot:C9IYP1;uniprot:A0A590UJE6;uniprot:B4E2H8;uniprot:A0A590UJR4;uniprot:A0A590UJR5;uniprot:A0A590UK13;uniprot:A0A590UJL2;uniprot:A0A590UJ18;uniprot:A0A590UJ95;uniprot:C9JCP6;uniprot:A0A590UJX2;uniprot:A0A590UJZ4;uniprot:A0A590UK70;uniprot:A0A590UK52;uniprot:A0A590UK31 +MAP2 GeneProduct ensembl:ENSG00000078018 ensembl:ENSG00000078018 ncbigene:4133 hgnc.symbol:MAP2 uniprot:A0A024R409;uniprot:P11137;uniprot:A8MZ31;uniprot:A0A669KB77;uniprot:H7BZB9;uniprot:E7EV03;uniprot:A0A024R3Z1 +FGF4 GeneProduct ensembl:ENSG00000075388 ensembl:ENSG00000075388 ncbigene:2249 hgnc.symbol:FGF4 uniprot:A0A7U3JW12;uniprot:P08620 +GATA6 GeneProduct ensembl:ENSG00000141448 ensembl:ENSG00000141448 ncbigene:2627 hgnc.symbol:GATA6 uniprot:Q92908 +CD34 GeneProduct ensembl:ENSG00000174059 ensembl:ENSG00000174059 ncbigene:947 hgnc.symbol:CD34 uniprot:Q5JTA5;uniprot:P28906 +FUT4 GeneProduct ensembl:ENSG00000196371 ensembl:ENSG00000196371 ncbigene:2526 hgnc.symbol:FUT4 uniprot:P22083 +ADRA2A GeneProduct ensembl:ENSG00000150594 ensembl:ENSG00000150594 ncbigene:150 hgnc.symbol:ADRA2A uniprot:P08913 diff --git a/pathways/WP5417/WP5417.gpml b/pathways/WP5417/WP5417.gpml new file mode 100644 index 000000000..92587d265 --- /dev/null +++ b/pathways/WP5417/WP5417.gpml @@ -0,0 +1,818 @@ + + + This cell lineage map consists of a set of cell types emerging during neural differentiation. +A selection of cell type-specific markers was made based on literature +(e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; +Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; +Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; +Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) +to distinguish these different cell types. +This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014. + + This cell lineage map consists of a set of cell types emerging during neural differentiation. +A selection of cell type-specific markers was made based on literature +(e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; +Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; +Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; +Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) +to distinguish these different cell types. +This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014. + + f97 + b25 + ee5 + d34 + f6b + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + neuron + CL:0000540 + Cell Type + + + 10.1038/s41586-018-0578-0 + DOI + Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids + + + + + 10.14573/altex.2010.1.16 + DOI + Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing + + + + + + 10.1016/j.stem.2016.10.015 + DOI + Neural Subtype Specification from Human Pluripotent Stem Cells + + + + + + diff --git a/pathways/WP5417/WP5417.json b/pathways/WP5417/WP5417.json new file mode 100644 index 000000000..2d2062180 --- /dev/null +++ b/pathways/WP5417/WP5417.json @@ -0,0 +1,7872 @@ +{ + "entitiesById": { + "a12ef": { + "drawAs": "rect", + "fill": "#ffffff", + "fontFamily": "Arial", + "fontSize": 12, + "fontStyle": "normal", + "fontWeight": "normal", + "gpmlElementName": "DataNode", + "height": 20, + "id": "a12ef", + "kaavioType": "SingleFreeNode", + "lineHeight": 1.1, + "overflow": "hidden", + "padding": 8, + "stroke": 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map consists of a set of cell types emerging during neural differentiation. \r\nA selection of cell type-specific markers was made based on literature \r\n(e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; \r\nKügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; \r\nSpangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; \r\nTao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) \r\nto distinguish these different cell types. \r\nThis map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.", + "source": "WikiPathways-description" + } + ], + "contains": [ + "id1fbc7d0d", + "id22acf9f4", + "id22f4ab6e", + "id37451cf", + "id391115ed", + "id41f7141d", + "id819dd2d1", + "id87ba254", + "id96bde2de", + "idaab4a013", + "idae7b677d", + "idbc77918b", + "idc197271a", + "idc66c4bae", + "idcc0b23c1", + "idce1d810f", + "idd6a313c0", + "ide31e940", + "ad41f", + "pvjsgeneratedida01", + 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62c367656..f92ed2fb3 100644 --- a/pathways/WP5422/WP5422.gpml +++ b/pathways/WP5422/WP5422.gpml @@ -1,5 +1,5 @@ - + Schematic representation of IL-19 signaling pathway @@ -773,7 +773,7 @@ - + @@ -840,14 +840,14 @@ - + - + diff --git a/pathways/WP5422/WP5422.json b/pathways/WP5422/WP5422.json index 029aff4d8..a87c79dc4 100644 --- a/pathways/WP5422/WP5422.json +++ b/pathways/WP5422/WP5422.json @@ -696,7 +696,7 @@ ], "isPartOf": "pvjsgeneratedidffeac", "kaavioType": "Edge", - "markerEnd": "MimConversion", + "markerEnd": "Arrow", "points": [ { "attachmentDisplay": { @@ -742,7 +742,11 @@ "strokeWidth": 2, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000167", + "SBO:0000393", + "SBO:0000394", + "DirectedInteraction" ], "zIndex": 32995 }, @@ -8936,7 +8940,7 @@ ], "isPartOf": "pvjsgeneratedidffea5", "kaavioType": "Edge", - "markerEnd": "MimConversion", + "markerEnd": "Arrow", "points": [ { "attachmentDisplay": { @@ -8986,7 +8990,11 @@ "strokeWidth": 2, "type": [ "Interaction", - "Edge" 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