From c688db698a206acc9f99a5949d9354f482d49758 Mon Sep 17 00:00:00 2001 From: GitHub Action Date: Sat, 14 Oct 2023 02:30:06 +0000 Subject: [PATCH] Update JSON, SVG, PNG, TSV and GPML files --- pathways/WP5293/WP5293-bibliography.tsv | 27 + pathways/WP5293/WP5293-datanodes.tsv | 93 + pathways/WP5293/WP5293.gpml | 1489 +++ pathways/WP5293/WP5293.json | 11576 ++++++++++++++++++++++ pathways/WP5293/WP5293.png | Bin 0 -> 324811 bytes pathways/WP5293/WP5293.svg | 1791 ++++ pathways/WP5311/WP5311-datanodes.tsv | 32 +- pathways/WP5311/WP5311.gpml | 211 +- pathways/WP5311/WP5311.json | 471 +- pathways/WP5311/WP5311.png | Bin 432644 -> 407141 bytes pathways/WP5311/WP5311.svg | 338 +- 11 files changed, 15565 insertions(+), 463 deletions(-) create mode 100644 pathways/WP5293/WP5293-bibliography.tsv create mode 100644 pathways/WP5293/WP5293-datanodes.tsv create mode 100644 pathways/WP5293/WP5293.gpml create mode 100644 pathways/WP5293/WP5293.json create mode 100644 pathways/WP5293/WP5293.png create mode 100644 pathways/WP5293/WP5293.svg diff --git a/pathways/WP5293/WP5293-bibliography.tsv b/pathways/WP5293/WP5293-bibliography.tsv new file mode 100644 index 000000000..7fe0e2206 --- /dev/null +++ b/pathways/WP5293/WP5293-bibliography.tsv @@ -0,0 +1,27 @@ +ID Database Citation +10717473 Pubmed "Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Lutterbach B, Hiebert SW. Gene. 2000 Mar 21;245(2):223–35. PubMed Europe PMC Scholia" +11090075 Pubmed "The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. Müller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP. Blood. 2000 Dec 1;96(12):3894–9. PubMed Europe PMC Scholia" +11607818 Pubmed "Common themes in the pathogenesis of acute myeloid leukemia. Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, et al. Oncogene. 2001 Sep 10;20(40):5680–94. PubMed Europe PMC Scholia" +11721960 Pubmed "The role of the AML1 transcription factor in leukemogenesis. Lorsbach RB, Downing JR. Int J Hematol. 2001 Oct;74(3):258–65. PubMed Europe PMC Scholia" +12032780 Pubmed "Transcription factor fusions in acute leukemia: variations on a theme. Scandura JM, Boccuni P, Cammenga J, Nimer SD. Oncogene. 2002 May 13;21(21):3422–44. PubMed Europe PMC Scholia" +12193465 Pubmed "Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Gómez AM, Schwaller B, Porzig H, Vassort G, Niggli E, Egger M. Circ Res. 2002 Aug 23;91(4):323–30. PubMed Europe PMC Scholia" +12393465 Pubmed "The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, et al. Blood. 2003 Jan 1;101(1):270–7. PubMed Europe PMC Scholia" +12468433 Pubmed "Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, et al. Blood. 2003 Apr 15;101(8):3164–73. PubMed Europe PMC Scholia" +12529654 Pubmed "New mechanisms of AML1 gene alteration in hematological malignancies. Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C. Leukemia. 2003 Jan;17(1):9–16. PubMed Europe PMC Scholia" +12563308 Pubmed "Disruption of differentiation in human cancer: AML shows the way. Tenen DG. Nat Rev Cancer. 2003 Feb;3(2):89–101. PubMed Europe PMC Scholia" +12951584 Pubmed "The role of FLT3 in haematopoietic malignancies. Stirewalt DL, Radich JP. Nat Rev Cancer. 2003 Sep;3(9):650–65. PubMed Europe PMC Scholia" +15024077 Pubmed "Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Müller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, et al. Mol Cell Biol. 2004 Apr;24(7):2890–904. PubMed Europe PMC Scholia" +15160934 Pubmed "The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia. Jing Y. Leuk Lymphoma. 2004 Apr;45(4):639–48. PubMed Europe PMC Scholia" +15625120 Pubmed "Normal and oncogenic forms of the receptor tyrosine kinase kit. Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. Stem Cells. 2005;23(1):16–43. PubMed Europe PMC Scholia" +15985538 Pubmed "Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia. Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP. Blood. 2005 Oct 15;106(8):2827–36. PubMed Europe PMC Scholia" +16146838 Pubmed "Signal transduction of oncogenic Flt3. Choudhary C, Müller-Tidow C, Berdel WE, Serve H. Int J Hematol. 2005 Aug;82(2):93–9. PubMed Europe PMC Scholia" +16236521 Pubmed "The molecular pathogenesis of acute myeloid leukemia. Steffen B, Müller-Tidow C, Schwäble J, Berdel WE, Serve H. Crit Rev Oncol Hematol. 2005 Nov;56(2):195–221. PubMed Europe PMC Scholia" +16352814 Pubmed "ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, et al. Blood. 2006 Apr 15;107(8):3330–8. PubMed Europe PMC Scholia" +16642045 Pubmed "Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Martelli AM, Nyåkern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, et al. Leukemia. 2006 Jun;20(6):911–28. PubMed Europe PMC Scholia" +17554387 Pubmed "The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. Mikesch JH, Steffen B, Berdel WE, Serve H, Müller-Tidow C. Leukemia. 2007 Aug;21(8):1638–47. PubMed Europe PMC Scholia" +19075268 Pubmed "Dysregulation of the C/EBPalpha differentiation pathway in human cancer. Koschmieder S, Halmos B, Levantini E, Tenen DG. J Clin Oncol. 2009 Feb 1;27(4):619–28. PubMed Europe PMC Scholia" +19854140 Pubmed "Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Choudhary C, Olsen JV, Brandts C, Cox J, Reddy PNG, Böhmer FD, et al. Mol Cell. 2009 Oct 23;36(2):326–39. PubMed Europe PMC Scholia" +19855079 Pubmed "Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, et al. Blood. 2009 Dec 24;114(27):5499–511. PubMed Europe PMC Scholia" +29127384 Pubmed "Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death. Heo SK, Noh EK, Kim JY, Jeong YK, Jo JC, Choi Y, et al. Sci Rep. 2017 Nov 10;7(1):15278. PubMed Europe PMC Scholia" +31336846 Pubmed "Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How? Fernandez S, Desplat V, Villacreces A, Guitart AV, Milpied N, Pigneux A, et al. Int J Mol Sci. 2019 Jul 12;20(14):3429. PubMed Europe PMC Scholia" +33658491 Pubmed "GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia. Zhou C, Du J, Zhao L, Liu W, Zhao T, Liang H, et al. 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PubMed Europe PMC Scholia" diff --git a/pathways/WP5293/WP5293-datanodes.tsv b/pathways/WP5293/WP5293-datanodes.tsv new file mode 100644 index 000000000..e8367e71e --- /dev/null +++ b/pathways/WP5293/WP5293-datanodes.tsv @@ -0,0 +1,93 @@ +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI +dasatinib Metabolite chebi:49375 "" wikidata:Q419940 chebi:49375;chebi:49375 inchikey:ZBNZXTGUTAYRHI-UHFFFAOYSA-N +RETINOIC ACID Metabolite chebi:15367 "" wikidata:Q29417 chebi:15367;chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N +midostaurin Metabolite chebi:63452 "" wikidata:Q6842945 chebi:63452;chebi:63452 inchikey:BMGQWWVMWDBQGC-IIFHNQTCSA-N +Arsenic trioxide Metabolite chebi:49900 "" wikidata:Q423271 chebi:49900;chebi:49900 inchikey:GCPXMJHSNVMWNM-UHFFFAOYSA-N +PIP3 Metabolite chebi:16618 "" wikidata:Q28797898 chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N +RETINOIC ACID Metabolite chebi:15367 "" wikidata:Q29417 chebi:15367;chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N +radotinib Metabolite wikidata:Q15269680 "" wikidata:Q15269680 inchikey:DUPWHXBITIZIKZ-UHFFFAOYSA-N +gilteritinib Metabolite wikidata:Q27077802 "" wikidata:Q27077802 chebi:145372;chebi:145372 inchikey:GYQYAJJFPNQOOW-UHFFFAOYSA-N +sunitinib Metabolite chebi:38940 "" wikidata:Q417542 chebi:38940;chebi:38940 inchikey:WINHZLLDWRZWRT-ATVHPVEESA-N +lestaurtinib Metabolite wikidata:Q6531771 "" wikidata:Q6531771 chebi:91471;chebi:91471 inchikey:UIARLYUEJFELEN-LROUJFHJSA-N +crenolanib Metabolite wikidata:Q5184160 "" wikidata:Q5184160 chebi:145365;chebi:145365 inchikey:DYNHJHQFHQTFTP-UHFFFAOYSA-N +sorafenib Metabolite chebi:50924 "" wikidata:Q421136 chebi:50924;chebi:50924 inchikey:MLDQJTXFUGDVEO-UHFFFAOYSA-N +ponatinib Metabolite chebi:78543 "" wikidata:Q198728 chebi:78543;chebi:78543 inchikey:PHXJVRSECIGDHY-UHFFFAOYSA-N +quizartinib Metabolite chebi:90217 "" wikidata:Q7272714 chebi:90217;chebi:90217 inchikey:CVWXJKQAOSCOAB-UHFFFAOYSA-N +ibrutinib Metabolite chebi:76612 "" wikidata:Q5984881 chebi:76612;chebi:76612 inchikey:XYFPWWZEPKGCCK-GOSISDBHSA-N +fostamatinib Metabolite wikidata:Q5473550 "" wikidata:Q5473550 inchikey:GKDRMWXFWHEQQT-UHFFFAOYSA-N +entospletinib Metabolite wikidata:Q27077193 "" wikidata:Q27077193 inchikey:XSMSNFMDVXXHGJ-UHFFFAOYSA-N +GLI1 GeneProduct ncbigene:2735 "" ensembl:ENSG00000111087 ncbigene:2735 hgnc.symbol:GLI1 uniprot:P08151;uniprot:E9PIB9;uniprot:E9PQQ1 +PIM1 GeneProduct ensembl:ENSG00000137193 "" ensembl:ENSG00000137193 ncbigene:5292 hgnc.symbol:PIM1 uniprot:P11309;uniprot:A0A024RD25 +KIT GeneProduct ensembl:ENSG00000157404 "" ensembl:ENSG00000157404 ncbigene:3815 hgnc.symbol:KIT uniprot:A0A0U2N547;uniprot:P10721 +RUNX1 GeneProduct ensembl:ENSG00000159216 "" ensembl:ENSG00000159216 ncbigene:100506403;ncbigene:861 hgnc.symbol:RUNX1 uniprot:A0A0C4DG58;uniprot:A8MZI9;uniprot:C9JWM1;uniprot:V9GYT3;uniprot:H9KVB1;uniprot:Q01196;uniprot:V9GYT5 +FLT3-ITD GeneProduct ensembl:ENSG00000122025 "" ensembl:ENSG00000122025 ncbigene:2322 hgnc.symbol:FLT3 uniprot:E7ER61;uniprot:P36888 +GRB2 GeneProduct ensembl:ENSG00000177885 "" ensembl:ENSG00000177885 ncbigene:2885 hgnc.symbol:GRB2 uniprot:P62993;uniprot:B0LPF3;uniprot:J3QRL5;uniprot:J3KT38;uniprot:J3QLF6 +SOS1 GeneProduct ensembl:ENSG00000115904 "" ensembl:ENSG00000115904 ncbigene:6654 hgnc.symbol:SOS1 uniprot:G5E9C8;uniprot:Q07889;uniprot:C9K0N6 +SOS2 GeneProduct ensembl:ENSG00000100485 "" ensembl:ENSG00000100485 ncbigene:6655 hgnc.symbol:SOS2 uniprot:A0A087X277;uniprot:G3V5W3;uniprot:Q07890 +HRAS GeneProduct ensembl:ENSG00000174775 "" ensembl:ENSG00000174775 ncbigene:3265 hgnc.symbol:HRAS uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2 +KRAS GeneProduct ensembl:ENSG00000133703 "" ensembl:ENSG00000133703 ncbigene:3845 hgnc.symbol:KRAS uniprot:G3V4K2;uniprot:A0A024RAV5;uniprot:P01116;uniprot:L7RSL8;uniprot:G3V5T7 +NRAS GeneProduct ensembl:ENSG00000213281 "" ensembl:ENSG00000213281 ncbigene:4893 hgnc.symbol:NRAS uniprot:Q5U091;uniprot:P01111 +ARAF GeneProduct ncbigene:369 "" ensembl:ENSG00000078061 ncbigene:369 hgnc.symbol:ARAF uniprot:A0A024R178;uniprot:P10398 +RAF1 GeneProduct ensembl:ENSG00000132155 "" ensembl:ENSG00000132155 ncbigene:5894 hgnc.symbol:RAF1 uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6 +BRAF GeneProduct ensembl:ENSG00000157764 "" ensembl:ENSG00000157764 ncbigene:673 hgnc.symbol:BRAF uniprot:A0A2R8Y492;uniprot:A0A2R8Y8E0;uniprot:H7C4S5;uniprot:A0A2R8Y467;uniprot:A0A2R8YES9;uniprot:H7C560;uniprot:A0A2U3TZI2;uniprot:P15056;uniprot:A0A2R8YDP5;uniprot:H7C5K3;uniprot:A0A2R8Y679 +STAT3 GeneProduct ensembl:ENSG00000168610 "" ensembl:ENSG00000168610 ncbigene:6774 hgnc.symbol:STAT3 uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9 +STAT5A GeneProduct ensembl:ENSG00000126561 "" ensembl:ENSG00000126561 ncbigene:6776 hgnc.symbol:STAT5A uniprot:P42229;uniprot:A0A7I2YQY3;uniprot:A0A384N5W4;uniprot:K7EK35;uniprot:K7EIF9;uniprot:A0A7I2YQF1;uniprot:A0A7I2V380 +STAT5B GeneProduct ensembl:ENSG00000173757 "" ensembl:ENSG00000173757 ncbigene:6777 hgnc.symbol:STAT5B uniprot:C9J4I3;uniprot:P51692 +PIK3CA GeneProduct ensembl:ENSG00000121879 "" ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336 +PIK3CB GeneProduct ensembl:ENSG00000051382 "" ensembl:ENSG00000051382 ncbigene:5291 hgnc.symbol:PIK3CB uniprot:C9JYX0;uniprot:C9J345;uniprot:H7C527;uniprot:P42338;uniprot:H7C5C3;uniprot:H7C565;uniprot:Q68DL0;uniprot:H0Y871;uniprot:F8WDJ8 +PIK3CD GeneProduct ensembl:ENSG00000171608 "" ensembl:ENSG00000171608 ncbigene:5293 hgnc.symbol:PIK3CD uniprot:B7ZM44;uniprot:F8W9P4;uniprot:O00329;uniprot:A0A2K8FKV1 +PIK3R1 GeneProduct ensembl:ENSG00000145675 "" ensembl:ENSG00000145675 ncbigene:5295 hgnc.symbol:PIK3R1 uniprot:P27986;uniprot:A0A2X0SFG1;uniprot:E5RGI8;uniprot:H0YBC2;uniprot:H0YB27;uniprot:E5RK66;uniprot:E5RJY0;uniprot:B3KWZ7;uniprot:E5RHI0 +PIK3R2 GeneProduct ensembl:ENSG00000105647 "" ensembl:ENSG00000105647 ncbigene:5296 hgnc.symbol:PIK3R2 uniprot:E9PFP1;uniprot:O00459;uniprot:A0A7I2U3A3;uniprot:V9GYJ4;uniprot:A0A087X257;uniprot:A0A5F9ZHY3 +PIK3R3 GeneProduct ensembl:ENSG00000117461 "" ensembl:ENSG00000117461 ncbigene:8503 hgnc.symbol:PIK3R3 uniprot:Q5T4P3;uniprot:Q92569 +AKT1 GeneProduct ensembl:ENSG00000142208 "" ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56 +AKT2 GeneProduct ensembl:ENSG00000105221 "" ensembl:ENSG00000105221 ncbigene:208 hgnc.symbol:AKT2 uniprot:M0QZK3;uniprot:J3QKW1;uniprot:A0A5F9ZHJ8;uniprot:E7EVP8;uniprot:J3KRI8;uniprot:C9JIJ1;uniprot:J3QLS6;uniprot:A8MX96;uniprot:C9JIF6;uniprot:A0A0A0MRF1;uniprot:J3QL45;uniprot:M0R0P9;uniprot:C9J258;uniprot:M0QZW8;uniprot:J3KTC6;uniprot:A0A1B0GXA2;uniprot:M0R275;uniprot:C9JC83;uniprot:J3KSY8;uniprot:J3KT31;uniprot:P31751;uniprot:C9JHS6;uniprot:J3KTP4;uniprot:M0R283 +AKT3 GeneProduct ensembl:ENSG00000117020 "" ensembl:ENSG00000117020 ncbigene:10000 hgnc.symbol:AKT3 uniprot:A0A7P0T8T9;uniprot:A0A7P0TBJ6;uniprot:A0A5F9ZHU3;uniprot:A0A7P0TB29;uniprot:Q9Y243;uniprot:A0A5F9ZHA9;uniprot:A0A5F9ZGY0;uniprot:A0A5F9ZGZ4;uniprot:A0A5K1VW74;uniprot:A0A7P0T872;uniprot:A0A7P0TB32 +CHUK GeneProduct ensembl:ENSG00000213341 "" ensembl:ENSG00000213341 ncbigene:1147 hgnc.symbol:CHUK uniprot:O15111 +IKBKB GeneProduct ensembl:ENSG00000104365 "" ensembl:ENSG00000104365 ncbigene:3551 hgnc.symbol:IKBKB uniprot:E5RGA0;uniprot:E5RFG5;uniprot:E5RJH2;uniprot:O14920;uniprot:A0A499FJS7;uniprot:A0A7P0SVL5;uniprot:A0A7P0NCV2;uniprot:E5RFT3;uniprot:E5RGW5;uniprot:A0A7I2V4L0;uniprot:J3KNS5;uniprot:G3V105;uniprot:E5RIW0 +IKBKG GeneProduct ensembl:ENSG00000269335 "" ensembl:ENSG00000269335 ncbigene:8517 hgnc.symbol:IKBKG uniprot:C9JCG6;uniprot:A0A087X1K7;uniprot:D3DWY0;uniprot:C9J2V2;uniprot:A0A087WWQ9;uniprot:A0A087X0G7;uniprot:A0A087X1B1;uniprot:C9JN51;uniprot:A0A087WV30;uniprot:C9JH59;uniprot:Q9Y6K9;uniprot:A0A087WUW6 +BAD GeneProduct ensembl:ENSG00000002330 "" ensembl:ENSG00000002330 ncbigene:572 hgnc.symbol:BAD uniprot:F5GYS3;uniprot:A8MXU7;uniprot:A0A024R562;uniprot:F5H1R6;uniprot:Q92934;uniprot:F5H3B1 +MTOR GeneProduct ensembl:ENSG00000198793 "" ensembl:ENSG00000198793 ncbigene:2475 hgnc.symbol:MTOR uniprot:P42345 +NFKB1 GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 +RELA GeneProduct ncbigene:5970 "" ensembl:ENSG00000173039 ncbigene:5970 hgnc.symbol:RELA uniprot:E9PNV4;uniprot:E9PRX2;uniprot:E9PJR1;uniprot:E9PJZ9;uniprot:E9PKV4;uniprot:A0A087X0W8;uniprot:E9PM47;uniprot:Q04206;uniprot:E9PI38;uniprot:E9PQS6;uniprot:E9PKH5;uniprot:E9PNK5;uniprot:Q2TAM5;uniprot:E9PMD5;uniprot:H0YCB4;uniprot:E9PSE4 +MAP2K1 GeneProduct ncbigene:5604 "" ensembl:ENSG00000169032 ncbigene:5604 hgnc.symbol:MAP2K1 uniprot:B4DFY5;uniprot:H3BRW9;uniprot:A4QPA9;uniprot:Q02750 +MAPK1 GeneProduct ncbigene:5594 "" ensembl:ENSG00000100030 ncbigene:5594 hgnc.symbol:MAPK1 uniprot:P28482;uniprot:Q1HBJ4 +MAPK3 GeneProduct ncbigene:5595 "" ensembl:ENSG00000102882 ncbigene:5595 hgnc.symbol:MAPK3 uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9 +MAP2K2 GeneProduct ncbigene:5605 "" ensembl:ENSG00000126934 ncbigene:5605 hgnc.symbol:MAP2K2 uniprot:P36507;uniprot:M0R1B6 +EIF4EBP1 GeneProduct ensembl:ENSG00000187840 "" ensembl:ENSG00000187840 ncbigene:1978 hgnc.symbol:EIF4EBP1 uniprot:Q13541 +RPS6KB1 GeneProduct ensembl:ENSG00000108443 "" ensembl:ENSG00000108443 ncbigene:6198 hgnc.symbol:RPS6KB1 uniprot:K7EIM2;uniprot:K7ER06;uniprot:K7EMM2;uniprot:P23443 +RPS6KB2 GeneProduct ensembl:ENSG00000175634 "" ensembl:ENSG00000175634 ncbigene:6199 hgnc.symbol:RPS6KB2 uniprot:G3V2F1;uniprot:R4GN47;uniprot:Q9UBS0;uniprot:E9PIP7;uniprot:E9PQF6 +PIM2 GeneProduct ensembl:ENSG00000102096 "" ensembl:ENSG00000102096 ncbigene:11040 hgnc.symbol:PIM2 uniprot:Q9P1W9;uniprot:C9J8V9;uniprot:A0A024QYW7 +BCL2A1 GeneProduct ensembl:ENSG00000140379 "" ensembl:ENSG00000140379 ncbigene:597 hgnc.symbol:BCL2A1 uniprot:B4E1X9;uniprot:Q16548 +CEBPE GeneProduct ensembl:ENSG00000092067 "" ensembl:ENSG00000092067 ncbigene:1053 hgnc.symbol:CEBPE uniprot:Q15744 +SPI1 GeneProduct ensembl:ENSG00000066336 "" ensembl:ENSG00000066336 ncbigene:6688 hgnc.symbol:SPI1 uniprot:F5H3K6;uniprot:P17947;uniprot:F5GZ94 +RUNX1T1 GeneProduct ensembl:ENSG00000079102 "" ensembl:ENSG00000079102 ncbigene:862 hgnc.symbol:RUNX1T1 uniprot:E5RHJ8;uniprot:E7EQI9;uniprot:Q06455;uniprot:E5RI38;uniprot:E7ESA9;uniprot:E7ETA8;uniprot:E5RH30;uniprot:E7EQW3;uniprot:E5RH72;uniprot:E5RJ32;uniprot:E7EQW7;uniprot:E5RK76;uniprot:H0YBA6;uniprot:A0A1B0GX92;uniprot:E5RJE7;uniprot:A0A087WWT6;uniprot:E7EX23;uniprot:E7ERJ9;uniprot:H0YC25;uniprot:E7EWJ9;uniprot:H0YC43;uniprot:W8FW32;uniprot:E7EV92;uniprot:E5RG85;uniprot:E5RFQ3;uniprot:A0A0A0MSU1;uniprot:E7EQ59;uniprot:E5RJB3;uniprot:E7EQJ1;uniprot:E7ESL1 +RUNX1 GeneProduct ensembl:ENSG00000159216 "" ensembl:ENSG00000159216 ncbigene:100506403;ncbigene:861 hgnc.symbol:RUNX1 uniprot:A0A0C4DG58;uniprot:A8MZI9;uniprot:C9JWM1;uniprot:V9GYT3;uniprot:H9KVB1;uniprot:Q01196;uniprot:V9GYT5 +PML GeneProduct ensembl:ENSG00000140464 "" ensembl:ENSG00000140464 ncbigene:5371 hgnc.symbol:PML uniprot:H3BVD2;uniprot:H3BRN3;uniprot:H3BT57;uniprot:H3BUJ5;uniprot:P29590;uniprot:H3BT29 +RARA GeneProduct ensembl:ENSG00000131759 "" ensembl:ENSG00000131759 ncbigene:5914 hgnc.symbol:RARA uniprot:J3QRM2;uniprot:A8MUP8;uniprot:F1D8N9;uniprot:J3KSJ4;uniprot:P10276;uniprot:Q6I9R7 +RARA GeneProduct ensembl:ENSG00000131759 "" ensembl:ENSG00000131759 ncbigene:5914 hgnc.symbol:RARA uniprot:J3QRM2;uniprot:A8MUP8;uniprot:F1D8N9;uniprot:J3KSJ4;uniprot:P10276;uniprot:Q6I9R7 +ZBTB16 GeneProduct ensembl:ENSG00000109906 "" ensembl:ENSG00000109906 ncbigene:7704 hgnc.symbol:ZBTB16 uniprot:A0A804HJ45;uniprot:A0A804HIC1;uniprot:A0A024R3C6;uniprot:Q05516;uniprot:H0YGW2;uniprot:A0A0S2Z4J5;uniprot:F5H6C3 +CEBPA GeneProduct ensembl:ENSG00000245848 "" ensembl:ENSG00000245848 ncbigene:1050 hgnc.symbol:CEBPA uniprot:P49715 +CEBPA GeneProduct ensembl:ENSG00000245848 "" ensembl:ENSG00000245848 ncbigene:1050 hgnc.symbol:CEBPA uniprot:P49715 +JUP GeneProduct ensembl:ENSG00000173801 "" ensembl:ENSG00000173801 ncbigene:3728 hgnc.symbol:JUP uniprot:C9JK18;uniprot:C9JKY1;uniprot:C9JTX4;uniprot:P14923;uniprot:C9JPI2;uniprot:A0A0S2Z487;uniprot:C9J826;uniprot:K7ERP3 +CCND1 GeneProduct ensembl:ENSG00000110092 "" ensembl:ENSG00000110092 ncbigene:595 hgnc.symbol:CCND1 uniprot:P24385;uniprot:Q6FI00;uniprot:F5H437 +MYC GeneProduct ensembl:ENSG00000136997 "" ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 +PPARD GeneProduct ensembl:ENSG00000112033 "" ensembl:ENSG00000112033 ncbigene:5467 hgnc.symbol:PPARD uniprot:Q03181;uniprot:A0A024RCW6;uniprot:F1D8S7 +DUSP6 GeneProduct ensembl:ENSG00000139318 "" ensembl:ENSG00000139318 ncbigene:1848 hgnc.symbol:DUSP6 uniprot:Q16828;uniprot:A0A024RBC1;uniprot:F8VW29;uniprot:F8VZA4 +MYC GeneProduct ensembl:ENSG00000136997 "" ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 +CCNA2 GeneProduct ensembl:ENSG00000145386 "" ensembl:ENSG00000145386 ncbigene:890 hgnc.symbol:CCNA2 uniprot:P20248 +CCNA1 GeneProduct ensembl:ENSG00000133101 "" ensembl:ENSG00000133101 ncbigene:8900 hgnc.symbol:CCNA1 uniprot:A0A140VJG0;uniprot:P78396 +LEF1 GeneProduct ensembl:ENSG00000138795 "" ensembl:ENSG00000138795 ncbigene:51176 hgnc.symbol:LEF1 uniprot:D6RID7;uniprot:D6RAB1;uniprot:D6RIV1;uniprot:Q9UJU2 +TCF7 GeneProduct ensembl:ENSG00000081059 "" ensembl:ENSG00000081059 ncbigene:6932 hgnc.symbol:TCF7 uniprot:E5RG75;uniprot:E5RJ51;uniprot:E5RGQ1;uniprot:E5RG34;uniprot:E5RHL1;uniprot:H0YAR8;uniprot:H0YBC8;uniprot:H0YBM1;uniprot:P36402;uniprot:E5RGJ5;uniprot:B7WNT5;uniprot:H0YBP2 +TCF7L2 GeneProduct ensembl:ENSG00000148737 "" ensembl:ENSG00000148737 ncbigene:6934 hgnc.symbol:TCF7L2 uniprot:Q5VVR7;uniprot:Q5VVR8;uniprot:A0A0A0MTL7;uniprot:A0A1B0GVE1;uniprot:Q9NQB0;uniprot:B7Z9Z6;uniprot:A0A0D9SGH8;uniprot:Q6FHW4;uniprot:Q5VVR5;uniprot:A0A1B0GU84;uniprot:Q5JRY3;uniprot:C6ZRJ7;uniprot:C6ZRK5;uniprot:H0YEE5;uniprot:Q5JRY5;uniprot:Q5JRY4 +TCF7L1 GeneProduct ensembl:ENSG00000152284 "" ensembl:ENSG00000152284 ncbigene:83439 hgnc.symbol:TCF7L1 uniprot:Q9HCS4;uniprot:C9JPE3 +CD14 GeneProduct ensembl:ENSG00000170458 "" ensembl:ENSG00000170458 ncbigene:929 hgnc.symbol:CD14 uniprot:E7EVL5;uniprot:P08571;uniprot:D6RFL4;uniprot:D6RD81 +FCGR1A GeneProduct ensembl:ENSG00000150337 "" ensembl:ENSG00000150337 ncbigene:2209 hgnc.symbol:FCGR1A uniprot:P12314;uniprot:C9JSN8 +ITGAM GeneProduct ensembl:ENSG00000169896 "" ensembl:ENSG00000169896 ncbigene:3684 hgnc.symbol:ITGAM uniprot:I3NI33;uniprot:P11215;uniprot:H3BMV4 +SPI1 GeneProduct ensembl:ENSG00000066336 "" ensembl:ENSG00000066336 ncbigene:6688 hgnc.symbol:SPI1 uniprot:F5H3K6;uniprot:P17947;uniprot:F5GZ94 +CSF1R GeneProduct ensembl:ENSG00000182578 "" ensembl:ENSG00000182578 ncbigene:1436 hgnc.symbol:CSF1R uniprot:H0YAL5;uniprot:D6RGW1;uniprot:E9PEK4;uniprot:P07333 +PER2 GeneProduct ensembl:ENSG00000132326 "" ensembl:ENSG00000132326 ncbigene:8864 hgnc.symbol:PER2 uniprot:E9PD89;uniprot:O15055 +CSF1R GeneProduct ensembl:ENSG00000182578 "" ensembl:ENSG00000182578 ncbigene:1436 hgnc.symbol:CSF1R uniprot:H0YAL5;uniprot:D6RGW1;uniprot:E9PEK4;uniprot:P07333 +CSF2 GeneProduct ensembl:ENSG00000164400 "" ensembl:ENSG00000164400 ncbigene:1437 hgnc.symbol:CSF2 uniprot:P04141 +MPO GeneProduct ensembl:ENSG00000005381 "" ensembl:ENSG00000005381 ncbigene:4353 hgnc.symbol:MPO uniprot:J3QSF7;uniprot:P05164 +IL3 GeneProduct ensembl:ENSG00000164399 "" ensembl:ENSG00000164399 ncbigene:3562 hgnc.symbol:IL3 uniprot:P08700 +FLT3-ITD immature form GeneProduct ensembl:ENSG00000122025 "" ensembl:ENSG00000122025 ncbigene:2322 hgnc.symbol:FLT3 uniprot:E7ER61;uniprot:P36888 diff --git a/pathways/WP5293/WP5293.gpml b/pathways/WP5293/WP5293.gpml new file mode 100644 index 000000000..e2f120e71 --- /dev/null +++ b/pathways/WP5293/WP5293.gpml @@ -0,0 +1,1489 @@ + + + Acute Myeloid Leukemia is a cancer of the myeloid cell line of blood cells of the bone marrow. Rapid growth of cancer cells leads to the accumulation of neoplastic blasts in the node marrow, and interferes with the production of normal blood cells. + +AML develops as the consequence of a series of genetic changes. Two major types of changes have been described as crucial for leukemic transformation: +1. Disordered cell growth and up-regulation of cell survival genes. The most common of these activating events are in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sometimes in other RTKs. +2. Alterations in transcription factors regulating hematopoietic differentiation. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. Sometimes the transcription factors themselves are mutated. + +This description was adapted from KEGG (https://www.kegg.jp/pathway/map=map05221), Wikipedia (https://en.wikipedia.org/wiki/Acute_myeloid_leukemia) and Wolters Kluwer Up to Date (https://www.uptodate.com/contents/molecular-genetics-of-acute-myeloid-leukemia#:~:text=Acute%20myeloid%20leukemia%20(AML)%20develops,bone%20marrow%20and%20peripheral%20blood.). + cec + dd4 + f73 + cc3 + bc9 + d56 + fa7 + ee2 + d86 + d1f + + + + + + + + + + + + + + + + + + + + + + + + + + + a00 + + + + + cec + dca + + + + + ad9 + f2a + b83 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + e7d + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + aa2 + + + + + + + + + fa7 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + parentid=P04049; parentsymbol=RAF1; site=RPRGQRDssyyWEIE; position=ser338; sitegrpid=447742; ptm=p; direction=u + + + + + parentid=P04049; parentsymbol=RAF1; site=IGDFGLAtVksRWsG; position=thr491; sitegrpid=447748; ptm=p; direction=u + + + + + parentid=P15056; parentsymbol=BRAF; site=VARsNPKsPQKPIVR; position=ser151; sitegrpid=478631; ptm=p; direction=u + + + + + parentid=P31749; parentsymbol=AKT1; site=kDGAtMKtFCGtPEy; position=thr308; sitegrpid=447856; ptm=ub; direction=u + + + + + parentid=P31749; parentsymbol=AKT1; site=tAQMItItPPDQDDs; position=thr450; sitegrpid=447857; ptm=ub; direction=u + + + + + parentid=P31749; parentsymbol=AKT1; site=RPHFPQFsysAsGtA; position=ser473; sitegrpid=447855; ptm=ub; direction=u + + + + + parentid=P31751; parentsymbol=AKT2; site=sDGAtMKtFCGtPEy; position=thr309; sitegrpid=448537; ptm=p; direction=u + + + + + parentid=Q9Y243; parentsymbol=AKT3; site=tDAAtMKtFCGtPEy; position=thr305; sitegrpid=448521; ptm=p; direction=u + + + + + parentid=O15111; parentsymbol=CHUK; site=AKDVDQGsLCtsFVG; position=ser176; sitegrpid=447778; ptm=p; direction=u + + + + + parentid=O14920; parentsymbol=IKBKB; site=AkELDQGsLCtsFVG; position=ser177; sitegrpid=447492; ptm=p; direction=u + + + + + parentid=O14920; parentsymbol=IKBKB; site=DQGsLCtsFVGTLQy; position=ser181; sitegrpid=447489; ptm=p; direction=u + + + + + parent=Q92934 ; parentsymbol=BAD; site=PFrGrsRsAPPNLWA; position=ser99; sitegrpid=447862; ptm=p; direction=d + + + + + parentid=Q92934; parentsymbol=BAD; site=KGLPRPKsAGtAtQM; position=ser134; sitegrpid=447864; ptm=p; direction=d + + + + + parentid=P42345; parentsymbol=MTOR; site=RsRtRtDsysAGQsV; position=ser2448; sitegrpid=447578; ptm=p; direction=u + + + + + parentid=P42345; parentsymbol=MTOR; site=PTPAILEsLIsINNK; position=ser1415; sitegrpid=25745815; ptm=p; direction=u + + + + + parentid=Q04206; parentsymbol=RELA; site=sGDEDFSsIADMDFS; position=ser536; sitegrpid=447800; ptm=p; direction=u + + + + + parentid=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u + + + + + parentid=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u + + + + + parentid=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u + + + + + parentid=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u + + + + + parentid=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u + + + + + parentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u + + + + + parentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u + + + + + parentid=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u + + + + + parentid=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGtRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u + + + + + parentid=Q13541; parentsymbol=EIF4EBP1; site=GGtLFsttPGGtRII; position=thr46; sitegrpid=447496; ptm=p; direction=d + + + + + parentid=Q13541; parentsymbol=EIF4EBP1; site=rNsPVtktPPRDLPt; position=thr70; sitegrpid=447528; ptm=p; direction=d + + + + + parentid=Q13541; parentsymbol=EIF4EBP1; site=PPGDysttPGGtLFs; position=thr37; sitegrpid=447497; ptm=p; direction=d + + + + + parentid=P23443; parentsymbol=RPS6KB1; site=NQVFLGFtyVAPsVL; position=thr412; sitegrpid=448607; ptm=p; direction=u + + + + + parentid=P23443; parentsymbol=RPS6KB1; site=RFIGsPRtPVsPVkF; position=thr444; sitegrpid=448358; ptm=p; direction=u + + + + + parentid=P23443; parentsymbol=RPS6KB1; site=GsPRtPVsPVkFsPG; position=ser447; sitegrpid=448357; ptm=p; direction=u + + + + + + + + + + + + + + + + + + + + + + + + + + + ac6 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + a3d + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + bee + + + + + + + + ca3 + + + + + + + + + + + + + + + cf4 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + d16 + + + + + + + + d54 + + + + + + + + c62 + + + + + + + + a85 + + + + + + + + c05 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + a3d + + + + + + + + a3d + + + + + + + + + + + + + + + + bee + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + bone cancer pathway + PW:0000632 + Pathway Ontology + + + 15625120 + PubMed + Normal and oncogenic forms of the receptor tyrosine kinase kit. + Stem Cells + 2005 + Lennartsson J + Jelacic T + Linnekin D + Shivakrupa R + + + 11090075 + PubMed + The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. + Blood + 2000 + Müller C + Yang R + Park DJ + Serve H + Berdel WE + Koeffler HP + + + 12468433 + PubMed + Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. + Blood + 2003 + Mizuki M + Schwable J + Steur C + Choudhary C + Agrawal S + Sargin B + Steffen B + Matsumura I + Kanakura Y + Böhmer FD + Müller-Tidow C + Berdel WE + Serve H + + + 19075268 + PubMed + Dysregulation of the C/EBPalpha differentiation pathway in human cancer. + J Clin Oncol + 2009 + Koschmieder S + Halmos B + Levantini E + Tenen DG + + + 16236521 + PubMed + The molecular pathogenesis of acute myeloid leukemia. + Crit Rev Oncol Hematol + 2005 + Steffen B + Müller-Tidow C + Schwäble J + Berdel WE + Serve H + + + 12393465 + PubMed + The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. + Blood + 2003 + Vangala RK + Heiss-Neumann MS + Rangatia JS + Singh SM + Schoch C + Tenen DG + Hiddemann W + Behre G + + + 12951584 + PubMed + The role of FLT3 in haematopoietic malignancies. + Nat Rev Cancer + 2003 + Stirewalt DL + Radich JP + + + 19855079 + PubMed + Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. + Blood + 2009 + Rice KL + Hormaeche I + Doulatov S + Flatow JM + Grimwade D + Mills KI + Leiva M + Ablain J + Ambardekar C + McConnell MJ + Dick JE + Licht JD + + + 19854140 + 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Acute myeloid leukemia + Last Modified: 20231013174332 + Organism: Homo sapiens + + + diff --git a/pathways/WP5311/WP5311-datanodes.tsv b/pathways/WP5311/WP5311-datanodes.tsv index fbfb1f21b..1aebceba9 100644 --- a/pathways/WP5311/WP5311-datanodes.tsv +++ b/pathways/WP5311/WP5311-datanodes.tsv @@ -16,23 +16,23 @@ HSO3-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP060 GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AL00 "S_id 426
ECO:0008028" Forssman-like iGb4 Metabolite lipidmaps:LMSP0506AD00 "S_id 398" Fucalpha1-2Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BB00 "S_id 382
ECO:0008028" -397 Metabolite lipidmaps:LMSP0601GW00 "S_id 397" +NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GW00 "S_id 397
ECO:0008028" Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GS00 "ECO:0008028" -395 Metabolite lipidmaps:LMSP0506BI00 "S_id 395" -394 Metabolite lipidmaps:LMSP0506BH00 "S_id 394" -375 Metabolite lipidmaps:LMSP0506AW00 "S_id 375" -420 Metabolite lipidmaps:LMSP0601GQ00 "S_id 420" -422 Metabolite lipidmaps:LMSP0506AJ00 "S_id 422" -421 Metabolite lipidmaps:LMSP0506AI00 "S_id 421" -376 Metabolite lipidmaps:LMSP0601GV00 "S_id 376" -365 Metabolite lipidmaps:LMSP0601GH00 "s_id" -423 Metabolite lipidmaps:LMSP0601GR00 "S_id 423" -371 Metabolite lipidmaps:LMSP0601GI00 "S_id 371" -396 Metabolite lipidmaps:LMSP0506BJ00 "S_id 396" -416 Metabolite lipidmaps:LMSP0506AH00 "S_ID 416" -399 Metabolite lipidmaps:LMSP0601GX00 "S_id 399" -419 Metabolite lipidmaps:LMSP0601GP00 "S_id 419" -418 Metabolite lipidmaps:LMSP0601GO00 "S_id 418" +Fucalpha1-3GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BI00 "S_id 395
ECO:0008028" +Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BH00 "S_id 394
ECO:0008028" +Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AW00 "S_id 375
ECO:0008028" +GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GQ00 "S_id 420
ECO:0008028" +GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AJ00 "S_id 422
ECO:0008028" +GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AI00 "S_id 421
ECO:0008028" +NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GV00 "S_id 376
ECO:0008028" +NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GH00 "s_id
ECO:0008028" +GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GR00 "S_id 423
ECO:0008028" +NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GI00 "S_id 371
Type your comment here" +Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BJ00 "S_id 396
ECO:0008028" +GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AH00 "S_ID 416
ECO:0008028" +NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6(GalNAcbeta1-3Galalpha1-3)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GX00 "S_id 399
ECO:0008028" +GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GP00 "S_id 419
ECO:0008028" +GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GO00 "S_id 418" Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AN00 "S_id 429
ECO:0008028" GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AO00 "S_id 430
ECO:0008028" GalNAcbeta1-3Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BE00 "S_id 385" diff --git a/pathways/WP5311/WP5311.gpml b/pathways/WP5311/WP5311.gpml index 1198b9c30..54168d143 100644 --- a/pathways/WP5311/WP5311.gpml +++ b/pathways/WP5311/WP5311.gpml @@ -1,5 +1,5 @@ - + Isoglobo pathway in its entirety from [https://www.lipidmaps.org/resources/sphingomap SphinGOMAP]. Solid conversion arrows are documented according to Sphingomap. @@ -11,7 +11,7 @@ Metabolites coloured red are not yet in LIPIDMAPS Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur. cd1 f1f - + @@ -134,9 +134,10 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + S_id 397 - + ECO:0008028 + @@ -144,79 +145,93 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + S_id 395 - + ECO:0008028 + - + S_id 394 - + ECO:0008028 + - + S_id 375 - + ECO:0008028 + - + S_id 420 - + ECO:0008028 + - + S_id 422 - + ECO:0008028 + - + S_id 421 - + ECO:0008028 + - + S_id 376 - + ECO:0008028 + - + s_id - + ECO:0008028 + - + S_id 423 - + ECO:0008028 + - + S_id 371 - + Type your comment here + - + S_id 396 - + ECO:0008028 + - + S_ID 416 - + ECO:0008028 + - + S_id 399 - + ECO:0008028 + - + S_id 419 - + ECO:0008028 + - + S_id 418 - + @@ -328,8 +343,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -365,8 +380,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -380,21 +395,21 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + - - + + - + @@ -409,8 +424,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -423,8 +438,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -473,8 +488,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -488,7 +503,7 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + @@ -501,8 +516,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -516,7 +531,7 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + @@ -543,8 +558,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -586,7 +601,7 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + @@ -600,7 +615,7 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + @@ -613,22 +628,22 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + - - + + - + @@ -641,8 +656,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -655,8 +670,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -671,7 +686,7 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - + @@ -698,8 +713,8 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + @@ -733,106 +748,106 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - + + - - + + - + - + - + - - + + - - + + - - + + - - + + - - + + - + - + - + - + - + @@ -907,14 +922,6 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th - - 21942574 - PubMed - Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics - Chem Rev. - 2011 - Alfred H. Merrill, Jr. - sphingolipid metabolic pathway PW:0000197 @@ -929,6 +936,14 @@ Metabolites with a dotted box are hypothetical. These may or may not exist on th Ronak Y Patel Petety V Balaji + + 21942574 + PubMed + Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics + Chem Rev. + 2011 + Alfred H. Merrill, Jr. + 15938018 PubMed diff --git a/pathways/WP5311/WP5311.json b/pathways/WP5311/WP5311.json index 66701fa19..895fc1ad2 100644 --- a/pathways/WP5311/WP5311.json +++ b/pathways/WP5311/WP5311.json @@ -196,6 +196,9 @@ "comments": [ { "content": "S_id 375" + }, + { + "content": "ECO:0008028" } ], "drawAs": "rect", @@ -205,7 +208,7 @@ "fontStyle": "normal", "fontWeight": "normal", "gpmlElementName": "DataNode", - "height": 25, + "height": 37.617554858934135, "id": "a40b2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -215,7 +218,7 @@ "strokeDasharray": "5,3", "strokeWidth": 1, "textAlign": "center", - "textContent": "375", + "textContent": "Galbeta1-4(Fucalpha1-3)\nGlcNAcbeta1-3Galalpha1-3\nGalbeta1-4Glcbeta-Cer", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -226,12 +229,12 @@ ], "verticalAlign": "middle", "whiteSpace": "pre", - "width": 90, + "width": 167.71159874608125, "wpType": "Metabolite", - "x": 890.7421205165807, + "x": 850.3134796238246, "xrefDataSource": "LIPID MAPS", "xrefIdentifier": "LMSP0506AW00", - "y": 863.4642857142844, + "y": 852.6645768025078, "zIndex": 32774 }, "a4421": { @@ -262,8 +265,8 @@ 1, 0 ], - "x": 1220.0674159705386, - "y": 525.5444979239035 + "x": 1329.1536050156742, + "y": 513.9282050748045 }, { "attachmentDisplay": { @@ -281,8 +284,8 @@ 1, 0 ], - "x": 1274.6136007094942, - "y": 459.1071469151233 + "x": 1405.027628817751, + "y": 449.3615671879692 } ], "stroke": "#000000", @@ -298,6 +301,9 @@ "comments": [ { "content": "s_id" + }, + { + "content": "ECO:0008028" } ], "drawAs": "rect", @@ -307,7 +313,7 @@ "fontStyle": "normal", "fontWeight": "normal", "gpmlElementName": "DataNode", - "height": 25, + "height": 44.25377249343059, "id": "a656d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -317,7 +323,7 @@ "strokeDasharray": "5,3", "strokeWidth": 1, "textAlign": "center", - "textContent": "365", + "textContent": 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- - - - 420 + + + + GalNAcbeta1-3Galalpha1-3 + (NeuAcalpha2-3Galbeta1-4 + GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 422 + + + + GalNAcbeta1-3Galalpha1-3 + (GalNAcbeta1-4Galbeta1-4 + GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 421 + + + + GalNAcalpha1-3GalNAcbeta1-3 + Galalpha1-3(Galbeta1-4 + GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 376 + + + + NeuAcalpha1-3Galbeta1-4 + GlcNAcbeta1-3Galalpha1-3 + (GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer - - - - 365 + + + + NeuAcalpha2-3Galbeta1-4 + (Fucalpha1-3)GlcNAcbeta1-3 + Galalpha1-3Galbeta1-4Glcbeta-Cer - - - - 423 + + + + GalNAcbeta1-3Galalpha1-3 + (GalNAcbeta1-4Galbeta1-4 + GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 371 + + + + NeuAcalpha2-3Galbeta1-4 + (Fucalpha1-3)GlcNAcbeta1-3 + Galalpha1-3(GalNAcbeta1-4) + Galbeta1-4Glcbeta-Cer - - - - 396 + + + + Galbeta1-4(Fucalpha1-3) + GlcNAcbeta1-3Galalpha1-3 + (GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer - - - - 416 + + + + GalNAcalpha1-3GalNAcbeta1-3 + Galalpha1-3(GalNAcbeta1-4 + Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 399 + + + + NeuAcalpha2-3(GalNAcbeta1-4) + Galbeta1-4GlcNAcbeta1-6 + (GalNAcbeta1-3Galalpha1-3)Galbeta1-4Glcbeta-Cer - - - - 419 + + + + GalNAcalpha1-3GalNAcbeta1-3 + Galalpha1-3(NeuAcalpha2-3 + Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer - - - - 418 + + + + GalNAcalpha1-3GalNAcbeta1-3 + Galalpha1-3(NeuAcalpha2-3 + (GalNAcbeta1-4)Galbeta1-4 + GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer @@ -1155,78 +1189,78 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -1276,7 +1310,7 @@ Name: Isoglobo series sphingolipids - Last Modified: 20231012192138 + Last Modified: 20231013130404 Organism: Homo sapiens