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Add enzymes/genes/proteins from a group to an interaction #52

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DeniseSl22 opened this issue Jul 25, 2018 · 0 comments
Open

Add enzymes/genes/proteins from a group to an interaction #52

DeniseSl22 opened this issue Jul 25, 2018 · 0 comments

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@DeniseSl22
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In the RDF, all the GeneProduct/Protein DataNodes are stored as being part of the pathway.

However, if a geneprod/protein is part of a group or complex, there is no connection to the interaction it is connected to... The dcterms:isPartOf only refers to the PW, not to an interaction.
See my statements in bold from the last GPML2RDF run from Jenkins.

See for example: WP1604; UGT1A6 info in the RDF for the group:

http://identifiers.org/ensembl/ENSG00000167165
a wp:Protein , wp:DataNode ;
rdfs:label "UGT1A6"^^xsd:string ;
dc:identifier http://identifiers.org/ensembl/ENSG00000167165 ;
dc:source "Ensembl"^^xsd:string ;
dcterms:identifier "ENSG00000167165"^^xsd:string ;
dcterms:isPartOf http://identifiers.org/wikipathways/WP1604_r95222 ;
wp:bdbEnsembl http://identifiers.org/ensembl/ENSG00000167165 ;
wp:bdbEntrezGene http://identifiers.org/ncbigene/54578 ;
wp:bdbHgncSymbol http://identifiers.org/hgnc.symbol/UGT1A6 ;
wp:bdbUniprot http://identifiers.org/uniprot/C9JMY5 , http://identifiers.org/uniprot/H7C5F8 , http://identifiers.org/uniprot/B5MCT4 , http://identifiers.org/uniprot/P19224 , http://identifiers.org/uniprot/Q5DSZ8 ;
wp:isAbout http://rdf.wikipathways.org/Pathway/WP1604_r95222/DataNode/a2799 .

While for a protein that has been connected separately to an interaction (such as Cyp2D6):

http://identifiers.org/ncbigene/1565
a wp:GeneProduct , wp:DataNode ;
rdfs:label "CYP2D6"^^xsd:string ;
dc:identifier http://identifiers.org/ncbigene/1565 ;
dc:source "Entrez Gene"^^xsd:string ;
dcterms:bibliographicCitation http://identifiers.org/pubmed/16778732 , http://identifiers.org/pubmed/15625333 , http://identifiers.org/pubmed/1782973 ;
dcterms:identifier "1565"^^xsd:string ;
dcterms:isPartOf http://rdf.wikipathways.org/Pathway/WP1604_r95222/WP/Interaction/id67727403 , http://identifiers.org/wikipathways/WP1604_r95222 ;
wp:bdbEnsembl http://identifiers.org/ensembl/ENSG00000100197 ;
wp:bdbEntrezGene http://identifiers.org/ncbigene/1565 , http://identifiers.org/ncbigene/107987479 , http://identifiers.org/ncbigene/107987478 ;
wp:bdbHgncSymbol http://identifiers.org/hgnc.symbol/CYP2D6 ;
wp:bdbUniprot http://identifiers.org/uniprot/E7ENE7 , http://identifiers.org/uniprot/C1ID52 , http://identifiers.org/uniprot/H7BY38 , http://identifiers.org/uniprot/P10635 ;
wp:isAbout http://rdf.wikipathways.org/Pathway/WP1604_r95222/DataNode/a5cfa .

And see the following example (WP2542) for the complex for MsrB2 (only connected to PW):

http://identifiers.org/ensembl/ENSG00000148450
a wp:GeneProduct , wp:DataNode ;
rdfs:label "MsrB2"^^xsd:string ;
dc:identifier http://identifiers.org/ensembl/ENSG00000148450 ;
dc:source "Ensembl"^^xsd:string ;
dcterms:identifier "ENSG00000148450"^^xsd:string ;
dcterms:isPartOf http://identifiers.org/wikipathways/WP2542_r97769 ;
wp:bdbEnsembl http://identifiers.org/ensembl/ENSG00000148450 ;
wp:bdbEntrezGene http://identifiers.org/ncbigene/22921 ;
wp:bdbHgncSymbol http://identifiers.org/hgnc.symbol/MSRB2 ;
wp:bdbUniprot http://identifiers.org/uniprot/H0YE51 , http://identifiers.org/uniprot/Q9Y3D2 ;
wp:isAbout http://rdf.wikipathways.org/Pathway/WP2542_r97769/DataNode/c2ce3 .

And for FMO (uniquely connected, and therefor connected to an interaction):
http://rdf.wikipathways.org/Pathway/WP2542_r97769/WP/Interaction/idd5b178a2
a wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
dcterms:isPartOf http://identifiers.org/wikipathways/WP2542_r97769 ;
wp:isAbout http://rdf.wikipathways.org/Pathway/WP2542_r97769/Interaction/idd5b178a2 ;
wp:participants http://identifiers.org/wikipedia.en/Flavin-containing_monooxygenase , http://rdf.wikipathways.org/Pathway/WP2542_r97769/WP/Interaction/id1d00538b ;
wp:source http://identifiers.org/wikipedia.en/Flavin-containing_monooxygenase ;
wp:target http://rdf.wikipathways.org/Pathway/WP2542_r97769/WP/Interaction/id1d00538b .

And, another gene (CYP1A2) which is part of a complex, and part of a unique interaction), is also not connected to an interaction (but is is present as 2 datanodes):

http://identifiers.org/ensembl/ENSG00000140505
a wp:GeneProduct , wp:DataNode ;
rdfs:label "CYP1A2"^^xsd:string ;
dc:identifier http://identifiers.org/ensembl/ENSG00000140505 ;
dc:source "Ensembl"^^xsd:string ;
dcterms:identifier "ENSG00000140505"^^xsd:string ;
dcterms:isPartOf http://identifiers.org/wikipathways/WP2542_r97769 ;
wp:bdbEnsembl http://identifiers.org/ensembl/ENSG00000140505 ;
wp:bdbEntrezGene http://identifiers.org/ncbigene/1544 ;
wp:bdbHgncSymbol http://identifiers.org/hgnc.symbol/CYP1A2 ;
wp:bdbUniprot http://identifiers.org/uniprot/P05177 ;
wp:isAbout http://rdf.wikipathways.org/Pathway/WP2542_r97769/DataNode/d8d1c , http://rdf.wikipathways.org/Pathway/WP2542_r97769/DataNode/e312f .

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