diff --git a/DESCRIPTION b/DESCRIPTION index 3bf4482..c763033 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Type: Package Package: CuratedAtlasQueryR Title: Queries the Human Cell Atlas -Version: 1.3.5 +Version: 1.3.6 Authors@R: c( person( "Stefano", diff --git a/R/counts.R b/R/counts.R index c0957c5..becb1b2 100644 --- a/R/counts.R +++ b/R/counts.R @@ -37,6 +37,11 @@ pseudobulk_url <- single_line_str( #' @inheritDotParams get_single_cell_experiment #' @importFrom cli cli_alert_warning #' @export +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_SingleCellExperiment <- function(...){ single_line_str("This function name is deprecated. Please use `get_single_cell_experiment()` instead") |> @@ -55,6 +60,11 @@ get_SingleCellExperiment <- function(...){ #' meta <- get_metadata() |> head(2) #' sce <- get_single_cell_experiment(meta) #' @export +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_single_cell_experiment <- function(data, ...){ raw_data <- collect(data) assert_that( @@ -77,6 +87,11 @@ get_single_cell_experiment <- function(data, ...){ #' pseudobulk <- meta |> get_pseudobulk() #' } #' @export +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_pseudobulk <- function(data, ...) { raw_data <- collect(data) assert_that( @@ -118,6 +133,11 @@ get_pseudobulk <- function(data, ...) { #' @importFrom cli cli_alert_success cli_alert_info #' @importFrom rlang .data #' @importFrom S4Vectors DataFrame +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_data_container <- function( data, assays = "counts", diff --git a/R/data.R b/R/data.R index d950d16..8bb4598 100644 --- a/R/data.R +++ b/R/data.R @@ -5,4 +5,10 @@ #' @format An object of class \code{SingleCellExperiment} #' @source HeOrganAtlasData Liver #' @keywords datasets +#' @docType data +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) "sample_sce_obj" diff --git a/R/import_metadata_and_counts.R b/R/import_metadata_and_counts.R index fb56b40..04882ab 100644 --- a/R/import_metadata_and_counts.R +++ b/R/import_metadata_and_counts.R @@ -20,6 +20,11 @@ #' data(sample_sce_obj) #' import_one_sce(sample_sce_obj, #' cache_dir = get_default_cache_dir()) +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) import_one_sce <- function( sce_obj, cache_dir = get_default_cache_dir() diff --git a/R/metadata.R b/R/metadata.R index f45cf11..7d5de48 100644 --- a/R/metadata.R +++ b/R/metadata.R @@ -15,6 +15,11 @@ cache <- rlang::env( #' @return A character vector of URLs to parquet files to download #' @examples #' get_database_url("metadata.0.2.3.parquet") +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_database_url <- function(databases = c("metadata.0.2.3.parquet", "fibrosis.0.2.3.parquet")) { glue::glue( "https://object-store.rc.nectar.org.au/v1/AUTH_06d6e008e3e642da99d806ba3ea629c5/metadata/{databases}") @@ -26,6 +31,11 @@ get_database_url <- function(databases = c("metadata.0.2.3.parquet", "fibrosis.0 #' @return A character scalar consisting of the URL #' @examples #' get_metadata(remote_url = SAMPLE_DATABASE_URL, cache_directory = tempdir()) +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) SAMPLE_DATABASE_URL <- single_line_str( "https://object-store.rc.nectar.org.au/v1/ AUTH_06d6e008e3e642da99d806ba3ea629c5/metadata/ @@ -142,6 +152,12 @@ SAMPLE_DATABASE_URL <- single_line_str( #' ```R #' get_metadata(cache_directory = path.expand('~')) #' ``` +#' +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_metadata <- function( remote_url = get_database_url(), cache_directory = get_default_cache_dir(), diff --git a/R/seurat.R b/R/seurat.R index 7648f8d..39a0e8c 100644 --- a/R/seurat.R +++ b/R/seurat.R @@ -21,7 +21,11 @@ as.sparse.DelayedMatrix <- function(x, ...) { #' @examples #' meta <- get_metadata() |> head(2) #' seurat <- get_seurat(meta) -#' +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_seurat <- function(...) { get_single_cell_experiment(...) |> as.Seurat(data = NULL) } diff --git a/R/unharmonised.R b/R/unharmonised.R index 48f4870..09629bc 100644 --- a/R/unharmonised.R +++ b/R/unharmonised.R @@ -45,6 +45,11 @@ UNHARMONISED_URL <- single_line_str( #' unharmonised_tbl <- dplyr::collect(unharmonised_meta[[dataset]]) #' dplyr::left_join(harmonised_meta, unharmonised_tbl, by=c("file_id", "cell_")) #' } +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_unharmonised_dataset <- function( dataset_id, cells = NULL, @@ -85,6 +90,11 @@ get_unharmonised_dataset <- function( #' @examples #' harmonised <- dplyr::filter(get_metadata(), tissue == "kidney blood vessel") #' unharmonised <- get_unharmonised_metadata(harmonised) +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_unharmonised_metadata <- function(metadata, ...){ args <- list(...) metadata |> diff --git a/R/utils.R b/R/utils.R index ae7108a..3161da5 100644 --- a/R/utils.R +++ b/R/utils.R @@ -48,6 +48,11 @@ single_line_str <- function(text){ #' @importFrom utils packageName #' @examples #' get_metadata(cache_directory = get_default_cache_dir()) +#' @references Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +#' A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +#' immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +#' doi:10.1101/2023.06.08.542671. +#' @source [Mangiola et al.,2023](https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3) get_default_cache_dir <- function() { packageName() |> R_user_dir( diff --git a/man/SAMPLE_DATABASE_URL.Rd b/man/SAMPLE_DATABASE_URL.Rd index 33d0927..dc7d007 100644 --- a/man/SAMPLE_DATABASE_URL.Rd +++ b/man/SAMPLE_DATABASE_URL.Rd @@ -8,6 +8,9 @@ demonstration, and vignette purposes only} \format{ An object of class \code{character} of length 1. } +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ SAMPLE_DATABASE_URL } @@ -21,4 +24,10 @@ demonstration, and vignette purposes only \examples{ get_metadata(remote_url = SAMPLE_DATABASE_URL, cache_directory = tempdir()) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} \keyword{datasets} diff --git a/man/get_SingleCellExperiment.Rd b/man/get_SingleCellExperiment.Rd index c02fe9b..63d9898 100644 --- a/man/get_SingleCellExperiment.Rd +++ b/man/get_SingleCellExperiment.Rd @@ -3,6 +3,9 @@ \name{get_SingleCellExperiment} \alias{get_SingleCellExperiment} \title{Gets a SingleCellExperiment from curated metadata} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_SingleCellExperiment(...) } @@ -22,3 +25,9 @@ Gets a SingleCellExperiment from curated metadata meta <- get_metadata() |> head(2) sce <- get_single_cell_experiment(meta) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_data_container.Rd b/man/get_data_container.Rd index d3a1578..d3a8735 100644 --- a/man/get_data_container.Rd +++ b/man/get_data_container.Rd @@ -3,6 +3,9 @@ \name{get_data_container} \alias{get_data_container} \title{Gets data from curated metadata container} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_data_container( data, @@ -41,3 +44,9 @@ Given a data frame of Curated Atlas metadata obtained from \code{\link[=get_meta returns a \code{\link[SummarizedExperiment:SummarizedExperiment-class]{SummarizedExperiment::SummarizedExperiment}} object corresponding to the samples in that data frame } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_database_url.Rd b/man/get_database_url.Rd index 0140f13..2962d1b 100644 --- a/man/get_database_url.Rd +++ b/man/get_database_url.Rd @@ -3,6 +3,9 @@ \name{get_database_url} \alias{get_database_url} \title{Returns the URLs for all metadata files} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_database_url( databases = c("metadata.0.2.3.parquet", "fibrosis.0.2.3.parquet") @@ -20,3 +23,9 @@ Returns the URLs for all metadata files \examples{ get_database_url("metadata.0.2.3.parquet") } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_default_cache_dir.Rd b/man/get_default_cache_dir.Rd index 834b7d0..5fffe1c 100644 --- a/man/get_default_cache_dir.Rd +++ b/man/get_default_cache_dir.Rd @@ -3,6 +3,9 @@ \name{get_default_cache_dir} \alias{get_default_cache_dir} \title{Returns the default cache directory with a version number} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_default_cache_dir() } @@ -15,3 +18,9 @@ Returns the default cache directory with a version number \examples{ get_metadata(cache_directory = get_default_cache_dir()) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_metadata.Rd b/man/get_metadata.Rd index 81d4fd6..5d5fbc1 100644 --- a/man/get_metadata.Rd +++ b/man/get_metadata.Rd @@ -3,6 +3,9 @@ \name{get_metadata} \alias{get_metadata} \title{Gets the Curated Atlas metadata as a data frame.} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_metadata( remote_url = get_database_url(), @@ -117,3 +120,9 @@ filtered_metadata <- get_metadata() |> ) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_pseudobulk.Rd b/man/get_pseudobulk.Rd index 49f602a..3295098 100644 --- a/man/get_pseudobulk.Rd +++ b/man/get_pseudobulk.Rd @@ -3,6 +3,9 @@ \name{get_pseudobulk} \alias{get_pseudobulk} \title{Gets a Pseudobulk from curated metadata} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_pseudobulk(data, ...) } @@ -39,3 +42,9 @@ meta <- get_metadata() |> filter(tissue_harmonised == "lung") pseudobulk <- meta |> get_pseudobulk() } } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_seurat.Rd b/man/get_seurat.Rd index b087bd4..b41d799 100644 --- a/man/get_seurat.Rd +++ b/man/get_seurat.Rd @@ -4,6 +4,9 @@ \alias{get_seurat} \title{Given a data frame of HCA metadata, returns a Seurat object corresponding to the samples in that data frame} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_seurat(...) } @@ -27,5 +30,10 @@ the samples in that data frame \examples{ meta <- get_metadata() |> head(2) seurat <- get_seurat(meta) - +} +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. } diff --git a/man/get_single_cell_experiment.Rd b/man/get_single_cell_experiment.Rd index 44de354..1024560 100644 --- a/man/get_single_cell_experiment.Rd +++ b/man/get_single_cell_experiment.Rd @@ -3,6 +3,9 @@ \name{get_single_cell_experiment} \alias{get_single_cell_experiment} \title{Gets a SingleCellExperiment from curated metadata} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_single_cell_experiment(data, ...) } @@ -36,3 +39,9 @@ Gets a SingleCellExperiment from curated metadata meta <- get_metadata() |> head(2) sce <- get_single_cell_experiment(meta) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_unharmonised_dataset.Rd b/man/get_unharmonised_dataset.Rd index 3402325..0ef0e3f 100644 --- a/man/get_unharmonised_dataset.Rd +++ b/man/get_unharmonised_dataset.Rd @@ -3,6 +3,9 @@ \name{get_unharmonised_dataset} \alias{get_unharmonised_dataset} \title{Returns unharmonised metadata for selected datasets.} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_unharmonised_dataset( dataset_id, @@ -49,3 +52,9 @@ unharmonised_tbl <- dplyr::collect(unharmonised_meta[[dataset]]) dplyr::left_join(harmonised_meta, unharmonised_tbl, by=c("file_id", "cell_")) } } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/get_unharmonised_metadata.Rd b/man/get_unharmonised_metadata.Rd index 0ef4afb..498bc43 100644 --- a/man/get_unharmonised_metadata.Rd +++ b/man/get_unharmonised_metadata.Rd @@ -3,6 +3,9 @@ \name{get_unharmonised_metadata} \alias{get_unharmonised_metadata} \title{Returns unharmonised metadata for a metadata query} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ get_unharmonised_metadata(metadata, ...) } @@ -45,3 +48,9 @@ utility that allows easy fetching of this data if necessary. harmonised <- dplyr::filter(get_metadata(), tissue == "kidney blood vessel") unharmonised <- get_unharmonised_metadata(harmonised) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/import_one_sce.Rd b/man/import_one_sce.Rd index 27d1104..09b2737 100644 --- a/man/import_one_sce.Rd +++ b/man/import_one_sce.Rd @@ -3,6 +3,9 @@ \name{import_one_sce} \alias{import_one_sce} \title{Import and process metadata and counts for a SingleCellExperiment object} +\source{ +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} +} \usage{ import_one_sce(sce_obj, cache_dir = get_default_cache_dir()) } @@ -26,3 +29,9 @@ data(sample_sce_obj) import_one_sce(sample_sce_obj, cache_dir = get_default_cache_dir()) } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} diff --git a/man/sample_sce_obj.Rd b/man/sample_sce_obj.Rd index ffd7952..7eef3eb 100644 --- a/man/sample_sce_obj.Rd +++ b/man/sample_sce_obj.Rd @@ -9,6 +9,8 @@ An object of class \code{SingleCellExperiment} } \source{ HeOrganAtlasData Liver + +\href{https://www.biorxiv.org/content/10.1101/2023.06.08.542671v3}{Mangiola et al.,2023} } \usage{ sample_sce_obj @@ -16,4 +18,10 @@ sample_sce_obj \description{ A sample SingleCellExperiment object from HeOrganAtlasData with transformation in metadata and assay } +\references{ +Mangiola, S., M. Milton, N. Ranathunga, C. S. N. Li-Wai-Suen, +A. Odainic, E. Yang, W. Hutchison et al. "A multi-organ map of the human +immune system across age, sex and ethnicity." bioRxiv (2023): 2023-06. +doi:10.1101/2023.06.08.542671. +} \keyword{datasets}