diff --git a/packages/replace/README.md b/packages/replace/README.md
index 533e09c9d..bd5ffb26f 100644
--- a/packages/replace/README.md
+++ b/packages/replace/README.md
@@ -70,6 +70,39 @@ For example, if you pass `typeof window` in `values` to-be-replaced, then you co
 - `typeof window.document` **will not** be replaced due to `(?!\.)` boundary
 - `typeof windowSmth` **will not** be replaced due to a `\b` boundary
 
+### `objectGuards`
+
+Type: `Boolean`<br>
+Default: `false`
+
+When replacing dot-separated object properties like `process.env.NODE_ENV`, will also replace `typeof process` object guard
+checks against the objects with the string `"object"`.
+
+For example:
+
+```js
+replace({
+  values: {
+    'process.env.NODE_ENV': '"production"'
+  }
+});
+```
+
+```js
+// Input
+if (typeof process !== 'undefined' && process.env.NODE_ENV === 'production') {
+  console.log('production');
+}
+// Without `objectGuards`
+if (typeof process !== 'undefined' && 'production' === 'production') {
+  console.log('production');
+}
+// With `objectGuards`
+if ('object' !== 'undefined' && 'production' === 'production') {
+  console.log('production');
+}
+```
+
 ### `preventAssignment`
 
 Type: `Boolean`<br>
diff --git a/packages/replace/src/index.js b/packages/replace/src/index.js
index f2085e7e8..dd001b234 100755
--- a/packages/replace/src/index.js
+++ b/packages/replace/src/index.js
@@ -24,6 +24,7 @@ function getReplacements(options) {
   delete values.exclude;
   delete values.sourcemap;
   delete values.sourceMap;
+  delete values.objectGuards;
   return values;
 }
 
@@ -35,10 +36,42 @@ function mapToFunctions(object) {
   }, {});
 }
 
+const objKeyRegEx = /^([_$a-zA-Z\xA0-\uFFFF][_$a-zA-Z0-9\xA0-\uFFFF]*)(\.([_$a-zA-Z\xA0-\uFFFF][_$a-zA-Z0-9\xA0-\uFFFF]*))+$/;
+function expandTypeofReplacements(replacements) {
+  Object.keys(replacements).forEach((key) => {
+    const objMatch = key.match(objKeyRegEx);
+    if (!objMatch) return;
+    let dotIndex = objMatch[1].length;
+    let lastIndex = 0;
+    do {
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)} ===`] = '"object" ===';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)} !==`] = '"object" !==';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)}===`] = '"object"===';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)}!==`] = '"object"!==';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)} ==`] = '"object" ===';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)} !=`] = '"object" !==';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)}==`] = '"object"===';
+      // eslint-disable-next-line no-param-reassign
+      replacements[`typeof ${key.slice(lastIndex, dotIndex)}!=`] = '"object"!==';
+      lastIndex = dotIndex + 1;
+      dotIndex = key.indexOf('.', lastIndex);
+    } while (dotIndex !== -1);
+  });
+}
+
 export default function replace(options = {}) {
   const filter = createFilter(options.include, options.exclude);
-  const { delimiters, preventAssignment } = options;
-  const functionValues = mapToFunctions(getReplacements(options));
+  const { delimiters, preventAssignment, objectGuards } = options;
+  const replacements = getReplacements(options);
+  if (objectGuards) expandTypeofReplacements(replacements);
+  const functionValues = mapToFunctions(replacements);
   const keys = Object.keys(functionValues).sort(longest).map(escape);
   const lookahead = preventAssignment ? '(?!\\s*=[^=])' : '';
   const pattern = delimiters
diff --git a/packages/replace/test/fixtures/form/process-check/_config.js b/packages/replace/test/fixtures/form/process-check/_config.js
new file mode 100644
index 000000000..43c1a7f9d
--- /dev/null
+++ b/packages/replace/test/fixtures/form/process-check/_config.js
@@ -0,0 +1,8 @@
+module.exports = {
+  description: 'Handles process type guards in replacements',
+  options: {
+    'process.env.NODE_ENV': '"production"',
+    preventAssignment: true,
+    objectGuards: true
+  }
+};
diff --git a/packages/replace/test/fixtures/form/process-check/input.js b/packages/replace/test/fixtures/form/process-check/input.js
new file mode 100644
index 000000000..dcce0a89f
--- /dev/null
+++ b/packages/replace/test/fixtures/form/process-check/input.js
@@ -0,0 +1,3 @@
+if (typeof process !== 'undefined' && process.env.NODE_ENV === 'production') {
+  console.log('production');
+}
diff --git a/packages/replace/test/fixtures/form/process-check/output.js b/packages/replace/test/fixtures/form/process-check/output.js
new file mode 100644
index 000000000..5fa7f8f80
--- /dev/null
+++ b/packages/replace/test/fixtures/form/process-check/output.js
@@ -0,0 +1 @@
+process.env.DEBUG = 'test';
diff --git a/packages/replace/test/snapshots/form.js.md b/packages/replace/test/snapshots/form.js.md
index eaeb3189d..c0d1e0c93 100644
--- a/packages/replace/test/snapshots/form.js.md
+++ b/packages/replace/test/snapshots/form.js.md
@@ -39,6 +39,14 @@ Generated by [AVA](https://avajs.dev).
       exclude␊
     `);`
 
+## process-check: Handles process type guards in replacements
+
+> Snapshot 1
+
+    `if (typeof process !== 'undefined' && "production" === 'production') {␊
+      console.log('production');␊
+    }`
+
 ## replace-nothing: replaces nothing
 
 > Snapshot 1
diff --git a/packages/replace/test/snapshots/form.js.snap b/packages/replace/test/snapshots/form.js.snap
index f0d05a94e..f87dfde21 100644
Binary files a/packages/replace/test/snapshots/form.js.snap and b/packages/replace/test/snapshots/form.js.snap differ