diff --git a/mypy/checkexpr.py b/mypy/checkexpr.py
index 376e1f811692..3d2c69073bc0 100644
--- a/mypy/checkexpr.py
+++ b/mypy/checkexpr.py
@@ -4321,8 +4321,18 @@ def visit_super_expr(self, e: SuperExpr) -> Type:
                     mro = e.info.mro
                     index = mro.index(type_info)
         if index is None:
-            self.chk.fail(message_registry.SUPER_ARG_2_NOT_INSTANCE_OF_ARG_1, e)
-            return AnyType(TypeOfAny.from_error)
+            if (
+                instance_info.is_protocol
+                and instance_info != type_info
+                and not type_info.is_protocol
+            ):
+                # A special case for mixins, in this case super() should point
+                # directly to the host protocol, this is not safe, since the real MRO
+                # is not known yet for mixin, but this feature is more like an escape hatch.
+                index = -1
+            else:
+                self.chk.fail(message_registry.SUPER_ARG_2_NOT_INSTANCE_OF_ARG_1, e)
+                return AnyType(TypeOfAny.from_error)
 
         if len(mro) == index + 1:
             self.chk.fail(message_registry.TARGET_CLASS_HAS_NO_BASE_CLASS, e)
diff --git a/test-data/unit/check-selftype.test b/test-data/unit/check-selftype.test
index a7dc41a2ff86..072978254049 100644
--- a/test-data/unit/check-selftype.test
+++ b/test-data/unit/check-selftype.test
@@ -792,6 +792,26 @@ reveal_type(f.copy())  # N: Revealed type is "__main__.File"
 b.copy()  # E: Invalid self argument "Bad" to attribute function "copy" with type "Callable[[T], T]"
 [builtins fixtures/tuple.pyi]
 
+[case testMixinProtocolSuper]
+from typing import Protocol
+
+class Base(Protocol):
+    def func(self) -> int:
+        ...
+
+class TweakFunc:
+    def func(self: Base) -> int:
+        return reveal_type(super().func())  # N: Revealed type is "builtins.int"
+
+class Good:
+    def func(self) -> int: ...
+class C(TweakFunc, Good): pass
+C().func()  # OK
+
+class Bad:
+    def func(self) -> str: ...
+class CC(TweakFunc, Bad): pass  # E: Definition of "func" in base class "TweakFunc" is incompatible with definition in base class "Bad"
+
 [case testBadClassLevelDecoratorHack]
 from typing_extensions import Protocol
 from typing import TypeVar, Any