diff --git a/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.cpp b/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.cpp
index 3fde426337db7d..6d8506de69769a 100644
--- a/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.cpp
+++ b/src/platform/OpenThread/GenericThreadStackManagerImpl_OpenThread.cpp
@@ -453,7 +453,11 @@ void GenericThreadStackManagerImpl_OpenThread<ImplClass>::_OnNetworkScanFinished
         // If Thread scanning was done before commissioning, turn off the IPv6 interface.
         if (otThreadGetDeviceRole(mOTInst) == OT_DEVICE_ROLE_DISABLED && !otDatasetIsCommissioned(mOTInst))
         {
-            otIp6SetEnabled(mOTInst, false);
+            DeviceLayer::SystemLayer().ScheduleLambda([this]() {
+                Impl()->LockThreadStack();
+                otIp6SetEnabled(mOTInst, false);
+                Impl()->UnlockThreadStack();
+            });
         }
 
         if (mpScanCallback != nullptr)