diff --git a/src/native.js b/src/native.js
index 05347e47f1f..a641beb71d5 100644
--- a/src/native.js
+++ b/src/native.js
@@ -364,7 +364,7 @@ export function getNativeTargeting(bid, {index = auctionManager.index} = {}) {
   let keyValues = {};
   const adUnit = index.getAdUnit(bid);
 
-  const globalSendTargetingKeys = deepAccess(
+  const globalSendTargetingKeys = adUnit?.nativeParams?.ortb == null && deepAccess(
     adUnit,
     `nativeParams.sendTargetingKeys`
   ) !== false;
@@ -806,20 +806,20 @@ export function toOrtbNativeResponse(legacyResponse, ortbRequest) {
 export function toLegacyResponse(ortbResponse, ortbRequest) {
   const legacyResponse = {};
   const requestAssets = ortbRequest?.assets || [];
-  legacyResponse.clickUrl = ortbResponse.link.url;
+  legacyResponse.clickUrl = ortbResponse.link?.url;
   legacyResponse.privacyLink = ortbResponse.privacy;
   for (const asset of ortbResponse?.assets || []) {
     const requestAsset = requestAssets.find(reqAsset => asset.id === reqAsset.id);
     if (asset.title) {
       legacyResponse.title = asset.title.text;
     } else if (asset.img) {
-      legacyResponse[requestAsset.img.type === NATIVE_IMAGE_TYPES.MAIN ? 'image' : 'icon'] = {
+      legacyResponse[requestAsset?.img?.type === NATIVE_IMAGE_TYPES.MAIN ? 'image' : 'icon'] = {
         url: asset.img.url,
         width: asset.img.w,
         height: asset.img.h
       };
     } else if (asset.data) {
-      legacyResponse[PREBID_NATIVE_DATA_KEYS_TO_ORTB_INVERSE[NATIVE_ASSET_TYPES_INVERSE[requestAsset.data.type]]] = asset.data.value;
+      legacyResponse[PREBID_NATIVE_DATA_KEYS_TO_ORTB_INVERSE[NATIVE_ASSET_TYPES_INVERSE[requestAsset?.data?.type]]] = asset.data.value;
     }
   }
 
diff --git a/test/spec/native_spec.js b/test/spec/native_spec.js
index a611a9dd789..877306c1c04 100644
--- a/test/spec/native_spec.js
+++ b/test/spec/native_spec.js
@@ -22,7 +22,7 @@ import { convertOrtbRequestToProprietaryNative, fromOrtbNativeRequest } from '..
 import {auctionManager} from '../../src/auctionManager.js';
 import {getRenderingData} from '../../src/adRendering.js';
 import {getCreativeRendererSource} from '../../src/creativeRenderers.js';
-import {deepClone} from '../../src/utils.js';
+import {deepClone, deepSetValue} from '../../src/utils.js';
 const utils = require('src/utils');
 
 const bid = {
@@ -211,6 +211,18 @@ describe('native.js', function () {
     expect(targeting.hb_native_foo).to.equal(bid.native.foo);
   });
 
+  it('does not include targeting keys if request is ortb', () => {
+    const targeting = getNativeTargeting(bid, deps({
+      adUnitId: bid.adUnitId,
+      nativeParams: {
+        ortb: {
+          assets: [{id: 1, type: '2'}]
+        }
+      }
+    }));
+    expect(Object.keys(targeting)).to.eql([]);
+  });
+
   it('can get targeting from null native keys', () => {
     const targeting = getNativeTargeting({...bid, native: {...bid.native, displayUrl: null}});
     expect(targeting.hb_native_displayurl).to.not.be.ok;
@@ -647,6 +659,14 @@ describe('native.js', function () {
       expect(actual.impressionTrackers).to.contain('https://sampleurl.com');
       expect(actual.impressionTrackers).to.contain('https://sample-imp.com');
     });
+    ['img.type', 'title.text', 'data.type'].forEach(prop => {
+      it(`does not choke when the request does not have ${prop}, but the response does`, () => {
+        const request = {ortb: {assets: [{id: 1}]}};
+        const response = {ortb: {assets: [{id: 1}]}};
+        deepSetValue(response, `assets.0.${prop}`, 'value');
+        toLegacyResponse(response, request);
+      })
+    })
   });
 
   describe('setNativeResponseProperties', () => {