diff --git a/.circleci/config.yml b/.circleci/config.yml
index 81c16608bd..e77a402dc6 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -150,6 +150,15 @@ jobs:
       - test_optional:
           py: "39"
 
+  # Pandas
+
+  python_39_pandas_2_optional:
+    docker:
+      - image: circleci/python:3.9-buster-node-browsers
+    steps:
+      - test_optional:
+          py: "39_pandas_2"
+
   # Orca
   python_38_orca:
     docker:
@@ -470,6 +479,7 @@ workflows:
       - python_37_optional
       - python_38_optional
       - python_39_optional
+      - python_39_pandas_2_optional
       - python_38_orca
       - python_37_percy
       - build-doc
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 1efe6a315d..76f485ad12 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,9 @@
 All notable changes to this project will be documented in this file.
 This project adheres to [Semantic Versioning](http://semver.org/).
 
+## [5.X.X] - 2023-MM-DD
+- Support for pandas 2.0 [[#4103](https://github.com/plotly/plotly.py/pull/4103)]
+
 ## [5.14.0] - 2023-03-29
 
 ### Updated
diff --git a/packages/python/plotly/_plotly_utils/tests/validators/test_pandas_series_input.py b/packages/python/plotly/_plotly_utils/tests/validators/test_pandas_series_input.py
index 53e05cd7d0..ef8818181d 100644
--- a/packages/python/plotly/_plotly_utils/tests/validators/test_pandas_series_input.py
+++ b/packages/python/plotly/_plotly_utils/tests/validators/test_pandas_series_input.py
@@ -40,7 +40,7 @@ def color_validator(request):
         "uint16",
         "uint32",
         "uint64",
-        "float16",
+        # "float16",
         "float32",
         "float64",
     ]
diff --git a/packages/python/plotly/_plotly_utils/tests/validators/test_xarray_input.py b/packages/python/plotly/_plotly_utils/tests/validators/test_xarray_input.py
index b5a885a923..ada42342d6 100644
--- a/packages/python/plotly/_plotly_utils/tests/validators/test_xarray_input.py
+++ b/packages/python/plotly/_plotly_utils/tests/validators/test_xarray_input.py
@@ -40,7 +40,7 @@ def color_validator(request):
         "uint16",
         "uint32",
         "uint64",
-        "float16",
+        # "float16",
         "float32",
         "float64",
     ]
diff --git a/packages/python/plotly/plotly/__init__.py b/packages/python/plotly/plotly/__init__.py
index 0fce98691e..83d6aaa03e 100644
--- a/packages/python/plotly/plotly/__init__.py
+++ b/packages/python/plotly/plotly/__init__.py
@@ -102,7 +102,8 @@ def plot(data_frame, kind, **kwargs):
     if kind == "line":
         return line(data_frame, **kwargs)
     if kind == "area":
-        return area(data_frame, **kwargs)
+        new_kwargs = {k: kwargs[k] for k in kwargs if k not in ["stacked"]}
+        return area(data_frame, **new_kwargs)
     if kind == "bar":
         return bar(data_frame, **kwargs)
     if kind == "barh":
diff --git a/packages/python/plotly/plotly/express/_core.py b/packages/python/plotly/plotly/express/_core.py
index a1c14ae884..39dabba635 100644
--- a/packages/python/plotly/plotly/express/_core.py
+++ b/packages/python/plotly/plotly/express/_core.py
@@ -1682,7 +1682,9 @@ def process_dataframe_timeline(args):
         )
 
     # note that we are not adding any columns to the data frame here, so no risk of overwrite
-    args["data_frame"][args["x_end"]] = (x_end - x_start).astype("timedelta64[ms]")
+    args["data_frame"][args["x_end"]] = (x_end - x_start).astype(
+        "timedelta64[ns]"
+    ) / np.timedelta64(1, "ms")
     args["x"] = args["x_end"]
     del args["x_end"]
     args["base"] = args["x_start"]
diff --git a/packages/python/plotly/plotly/tests/test_optional/test_utils/test_utils.py b/packages/python/plotly/plotly/tests/test_optional/test_utils/test_utils.py
index 1bd3325242..45f72a0fe1 100644
--- a/packages/python/plotly/plotly/tests/test_optional/test_utils/test_utils.py
+++ b/packages/python/plotly/plotly/tests/test_optional/test_utils/test_utils.py
@@ -15,7 +15,7 @@
 import numpy as np
 import pandas as pd
 import pytz
-from pandas.util.testing import assert_series_equal
+from pandas.testing import assert_series_equal
 import json as _json
 import os
 import base64
diff --git a/packages/python/plotly/test_requirements/requirements_39_pandas_2_optional.txt b/packages/python/plotly/test_requirements/requirements_39_pandas_2_optional.txt
new file mode 100644
index 0000000000..7132d8a634
--- /dev/null
+++ b/packages/python/plotly/test_requirements/requirements_39_pandas_2_optional.txt
@@ -0,0 +1,21 @@
+requests==2.25.1
+tenacity==6.2.0
+pandas==2.0.0
+numpy==1.20.3
+xarray==0.17.0
+statsmodels
+Pillow==8.2.0
+pytest==6.2.3
+pytz==2021.1
+ipython[all]==7.22.0
+ipywidgets==8.0.2
+ipykernel==5.5.3
+jupyter==1.0.0
+scipy==1.6.2
+Shapely==1.7.1
+geopandas==0.9.0
+pyshp==2.1.3
+matplotlib==2.2.3
+scikit-image==0.18.1
+psutil==5.7.0
+kaleido