Support for Oxford Nanopore?

[cdustinr]

Oxford Nanopore has a very appealing amplicon-based, size-unrestricted sequencing application. I have CRISPResso2 tightly integrated into our core's operations, but methods used with CRISPResso2 aren't really comparable with the higher error rates involved with ONT.

Is there any interest in developing ONT support for this package? I do appreciate that this would be a fundamental shift for some key components of the package. I'm not really sure how it would be implemented, but I suppose I'll leave that up to you.

Initially Ia had hoped that simply using WGS mode might work well enough, but that seems not to be the case.

[Colelyman]

Thank for your comment and request @cdustinr. This is something that we are actively exploring and hope to implement (unfortunately I can't provide a timeline now).

Others have found success using WGS mode where you set the region around the guide. Would you mind describing why WGS mode doesn't work for you?

Thanks for using CRISPResso2!
Cole